We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

This book describes the different approaches for drug delivery to the brain with an emphasis on the physiology of the blood-brain barrier (BBB) and the governing principles and concepts for drug delivery across the BBB

Lecture, Leiden Yemeni Studies Lecture Series

The chief aim of this study is to explore how classical Persian poetry and the Persian mysticism that is interwoven with the poetry have been used in the new politics of the Islamic Republic of Iran, especially during the Iran-Iraq war.

Debate

On 1 June 2022, Bruno Braak defended his thesis entitled 'Overcoming ruptures: Zande identity, governance, and tradition during cycles of war and displacement in South Sudan and Uganda (2014-2019).' The doctoral research was supervised by Prof.dr. J.M. Otto, Dr.ir. C.I.M. Jacobs, and Dr. C. Leonardi…

The land question had a crucial formative influence on Mayo politics in the decades before the First World War and this book shows the part played by many prominent nationalist figures such as Davitt, O’Brien, Dillon and MacBride in shaping the political landscape in Mayo.

The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…

This dissertation describes the history of the Ottoman county of Foçateyn as a case study of the process of transition from the Ottoman Empire to nation states.

Herta Mohr was a promising Egyptologist who died in Bergen-Belsen. Lawyer Amandus Wolfsbergen died in Auschwitz, without knowing that the his work would continue to be a respected authority for many years. Thanks to research by PhD candidate Adriënne Baars, some more personal information has been added…

The chain that supplies patients with new medicines consists of various complex links: from fundamental research to clinical tests and production. This entire chain is represented in Leiden. Leiden University, the Leiden University Medical Center (LUMC), and the companies on the Leiden Bio Science Park…

Students were able to continue their studies in September 1945 after the University had been closed for several years during the Second World War. This moment was celebrated for four days, with the traditional cortège, commemorative services and a party in the Botanical Garden. Queen Wilhelmina was…

Four years of protracted negotiations and bitter warfare passed between the declaration of Indonesian independence on 17 August, 1945, and the official transfer of sovereignty on 27 December, 1949.

Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…

Minister Grapperhaus wants to use intelligence services in the investigation of drug crime. There are many doubts about this wish in the intelligence world. Paul Abels, Professor by Special Appointment Governance of Intelligence and Security Services at the Institute of Security and Global Affairs (ISGA),…

Two Stolpersteine (stumbling stones) have been placed in front of the University Library in memory of the Jewish Cosman family. At the time of the Second World War, they lived in one of the houses where the library is now located.

These days we do not just have wars and civil wars – more of a global civil war, says Bashir Azizi, who received a PhD in April 2020 for his thesis on global citizenship. The second edition of his thesis was recently published.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Leiden chemical biologists led by Dr Mario van der Stelt have developed a method to facilitate the search for new drugs. This method has allowed them to take an important first step in the development of a drug against obesity.

Pharmacy undergraduate education at Leiden Pharmacy combines the strong scientific foundation of the bachelor programme Bio-Pharmaceutical Sciences with experience-based learning and a strong focus on pharmaceutical patient care and pharmaceutical treatment in the master programme Pharmacy.

Leiden researcher Ethan Mark has a mission, he explains in the alumni magazine Leidraad. He wants us to take off our Eurocentric glasses when we study the Second World War. We have focused on ourselves for far too long; after 75 years, it’s about time we listened to stories from the rest of the worl…

There are more molecules that could conceivably be candidate drugs than there are stars in the universe. How can we ever efficiently identify those molecules? Professor of AI and Medicinal Chemistry, Gerard van Westen: ‘I’m going to use artificial intelligence as the co-pilot to make an automated search.’…

Psychedelic drugs like magic mushrooms and LSD are embraced by some and seen as lethal by others. Cognitive psychologist Michiel van Elk delved into the world of psychedelic drugs and wrote a surprisingly sober book about them. ‘Without first-hand experience my story wouldn’t be complete.’

At high doses, drug candidate BIA 10-2474 binds not only to the protein that it targets, but to other proteins as well. It thus deactivates proteins that are involved in the metabolism of nerve cells. This is what an international group of researchers from Leiden University and Erasmus MC, among others,…

On 18 June 2019, Peter Kempees defended his thesis 'Hard power and the European Convention on Human Rights'. The doctoral research was supervised by Prof. R.A. Lawson and Prof. H. Duffy.

Odile Bodde tells about her stay in London at King's College...

Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…

On 10 May 1940, the Netherlands was taken completely by surprise by the attack of the German army. Wasn’t it? In his dissertation, Wouter Linmans debunks the idea that the Second World War took the Netherlands by surprise. ‘From 1935 onwards, all major political parties wanted to invest in the military.’…

What makes peace missions succeed or fail? Which new technologies will determine the outcome of wars? In recent decades, insufficient use has been made of knowledge of modern warfare, when this is crucial to European security. This is what Frans Osinga, Professor by Special Appointment of War Studies,…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Many pharmaceutical companies no longer have their own lab and are working more closely with universities and start-ups of scientists. Professor of Science-Based Business Simcha Jong is researching how scientific ideas result in new drugs, including at the Leiden Bio Science Park (LBSP).

Bioprinters that enable scientists to engineer complex tissues and organs. It sounds like science-fiction, but not for the scientists of the Alireza Mashaghi lab at the Leiden Academic Centre for Drug Research. The lab has recently been equipped with two state-of-the-art bioprinters: BioX and LumenX+.…

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Immediately connect with the needs of industry with your master’s degree. The new course Practical Aspects of Quality Management in Pharma and Biotech provides just that. The LACDR and LUMC set up the course together with the Biotech Training Facility, located at the Leiden Bio Science Park. The first…

Nuclear Magnetic Resonance (NMR) Spectroscopy is a non-destructive analytical technique that is used to study the nature and characteristics of molecules with an atomic level precision. It has a wide range of applications especially in synthetic chemistry, biological and biochemical research groups…

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process.

A group of confidants including a former student of Meijers managed to avert his deportation to a death camp. In her lecture on 27 November, Cleveringa Professor Marjan Schwegman revealed the history of the persecution of the Jewish Professor Eduard Meijers.

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Nowadays, it is almost impossible to imagine warfare without unmanned aerial vehicles, or drones. For instance, they have been deployed in the war in Iraq and Afghanistan. Are the current laws of war adequate to address the use of drones? PhD candidate James Welch will defend his thesis on 21 March.

How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.

A measured yet theoretically innovative exploration of how Islamophobia and radicalisation intersect and reinforce each other.

In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.

Frans Osinga has recently been appointed as Professor by special appointment of War Studies at the Institute of Security and Global Affairs in the Hague. Osinga is both professor and an officer of the Dutch Royal Air Force. Given current global developments, the concept of ‘war’ is far from an abstract…

Nature Reviews Drug Discovery volume 18, pages 82–84 (2019). The implications of target saturation for the use of drug–target residence time Wilbert de Witte, Meindert Danhof, Piet van der Graaf, and Elizabeth de Lange

Art of Captivity / Arte del Cautiverio tells a compelling story about Central America's drug war through a series of rich photographs. The book, which is entirely bilingual in English and Spanish, focuses on Guatemala, which has become the primary point of transit for cocaine produced in the Andes and…

After a year of war against Ukraine, professors André Gerrits, Antoaneta Dimitrova and Frans Osinga look back at Russian aggression and Western unity and ahead to the new offensive.

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…