The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Complaints against decisions not to prosecute in socially sensitive issues.

What is the neural basis of social decision-making across childhood, adolescence and adulthood and what are the developmental patterns in terms of behavior and brain activation?

Contact

As of 1 February 2009, PhD applications should no longer be sent to the International Office to be processed. The Graduate School will deal with its own applicants in future.

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

It is in the interest of all democracies for young people to learn the value of free debate, even on sensitive and potentially divisive issues like terrorism, argue Thorbjørn Jagland (secretary general of the Council of Europe), Sayeeda Warsi (UK parliamentarian), and Francesco Ragazzi (Institute of…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

PhD defence

Laboratory, observation and modeling work on the dissociation of polycyclic aromatic hydrocarbons in interstellar environments and the formation of new molecular species through the fragmentation process.

Research and design are two activities that are becoming increasingly important in the Dutch subjects O&O (‘research and design’) and NLT ('nature, life and technology’). The dissertation of Tessa Vossen (ICLON and Faculty of Science) indicates that teachers and students understand the importance of…

Computer scientist Bas van Stein conducted research at Tata Steel and BMW on how their production processes could be streamlined and optimised on the basis of data. As part of his research he developed some innovative products. PhD defence 20 September.

Marius Staring, Associate Professor at the LUMC has been awarded the Chan Zuckerberg Initiative funding for further development of image processing software Elastix

Rottgering

The quality of the care for our senior citizens could be improved. With an eye for the biological, social and management aspects, this Master’s programme provides important insights for improvements. The Master’s in Health, Ageing and Society starts you thinking, puts you to work and gives direction…

Ramautar

With the aid of the General History of Africa (GHA) series of books, PhD candidate Larissa Schulte Nordholt researched what it meant to decolonise the history of Africa. This proved to be a tricky process, which was hampered by politics and lack of funding. PhD defence on 1 December.

Patients with the same illness often receive the same treatment, even if the cause of the illness is different for each person. This represents a new step towards ultimately being able to offer every patient more personalised treatment.

Promotor: P.M. Brakefield

This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.

Research into the development of privacy-friendly care games for children.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

The Cyber Security lecturers are scholars and lecturers of Leiden University, Delft University of Technology and The Hague University of Applied Sciences.

The guest rooms are located on the top floor of our institute.

There are five categories of members within the Research School:

The place of European states and institutions in world politics is the core focus of this pillar. Research on this theme concerns European actors’ ability to promote peace, security and justice in their neighbourhood and to shape the future of global governance by translating its economic size into…

The research study presented in this dissertation focuses on issues pertaining to the reliability, generalizability, and validity of authentic performance assessments of teachers.

This book is the first comparative study of estimative intelligence and strategic surprise in a European context, complementing and testing insights from previous studies centred on the United States. It does extensive empirical analysis of open-source material and interviews in relation to three cases…

Once you have decided on your field of research, you should start looking for a supervisor as early as possible.

Citizens, journalists and scholars notice that foreign policy in, and of, the European Union, is ‘de-Europeanising’. Political scientist Daniel Thomas (Leiden University) offers a theoretical exploration of the likely implications. He expects that it will become more difficult for the EU to achieve…

Social evaluative fears during adolescence

The subject of motherhood is interwoven with themes of survival, power and identity. It is also at the heart of any consideration of women’s writing. Conversations of Motherhood sensitively charts common themes, intersecting experiences and related topics within the cultural specificities of South African…

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

Multi-Angle Dynamic Light Scattering (MADLS) is a technique that is used to determine properties of particles in suspension. The measurements give the hydrodynamic size distribution of individual particles as well as particle clusters, and assists in the interpretation of the stability of the particles…

This dissertation approaches collections of Andean mummies in European national and university museums as the focus to understand the relationship between objects, documents, and the practice of collecting in the period from 1850 to 1930. Over 200 mummies, kept by 18 different museums in Western European…

Written by a select international group of leading privacy scholars, Social Dimensions of Privacy endorses and develops an innovative approach to privacy.

Modern society is connected through electronic and mobile devices, which we call the Internet of Things (IoT).

The Leiden Institute for Brain and Cognition (LIBC) is a network that stimulates interdisciplinary exchange of knowledge and expertise on topics related to brain and cognition and focuses on science valorisation and outreach.