402 search results for “lipid crystal” in the Public website
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Leiden University Centre for International Relations
The Leiden University Centre for International Relations (LUCIR) is a multi-disciplinary platform promoting research and education on international relations at Leiden University.
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Stable single molecules for quantum optics and all-optical switches
Promotor: Prof.dr. M.A.G.J. Orrit
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Michel Orrit Lab - Single Molecule Optics
Since the early 1990s, one can isolate the optical signal of a single molecule and single-molecule spectroscopy has quickly grown into an important research field.
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Riches Beyond the Horizon
Long-distance Trade in Early Medieval Landscapes (ca. 6th-12th centuries)
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Visualizing cityscapes of Classical antiquity
This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.
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Joan van der Waals colloquium
The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Research
Research at the MCBIM group is comprised of the following research themes:
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Metabolomics and Analytics Centre
The ambition of the Metabolomics and Analytics Centre led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies on the…
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Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
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Light-activatable ruthenium-based anticancer prodrugs
Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Leiden Academic Centre for Drug Research
The Leiden Academic Centre for Drug Research (LACDR) is a centre of excellence for multidisciplinary research on drug discovery and development.
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Faculty of Science
Explore the unknown in order to be able to innovate in the distant future.
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Leiden Political Economy Group (L-PEG)
The Leiden Political Economy Group (L-PEG) is a multi-disciplinary network of scholars with a research interest in (comparative / global) political economy based at Leiden University. Our members belong to various institutes and faculties across Leiden University, and from other universities across…
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On Display: Instagram, the Self, and the City
Discover the impact of Instagram on our daily lives in the book On Display. Boy and Uitermark delve into the platform's influence on our social interactions.
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Leiden Institute of Chemistry
The Leiden Institute of Chemistry (LIC) is the basis for research and collaborations of the Leiden chemistry groups. Chemistry is the central science enabling a healthy future in a sustainable society. Chemistry researchers at Leiden University take a fundamental approach in finding tailored solutions…
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Surface Reactivity of Activated CO2 Selective use of energy in splitting CO2
Juurlink
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PhD Thesis: Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Recently, the PhD thesis of Lolu Danso Eweje appeared entitled ’Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin’.
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Supramolecular and Biomaterials Chemistry
Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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John Mydosh and the mystery of the Hidden Order
A 35-year-old uranium crystal will not disclose its secret: what causes a dramatic phase transition at 17.5 Kelvin? Thanks to a new artificial intelligence approach, half of the possible explanations are excluded, but the definitive answer remains to be found. 'It is very frustrating', says physicist…
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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Key publications
Key publications of the Cardiovascular Pharmacology group
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PhD Theses
A full overview of MCBIM PhD theses.
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Metals in Catalysis, Biomimetics & Inorganic Materials
Coordination chemistry is the chemistry of metal atoms
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Real-time solid-state NMR spectroscopy inside living cells
Researchers from the Leiden Institute of Chemistry show proof of principle that live-cell structural changes and metabolic processes can be followed in real time with NMR spectroscopy. They performed their study on photosynthetic green algae that are metabolically flexible and can sustain energy generation…
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Colloidal LEGO with peptides
Kros
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Data-Driven Drug Discovery Network (D4N)
The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.
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Events calendar
LIAS PhD program activities include thematic coursework (the PhD Seminars), generic skills training, library training, research presentations, social events, and so on. They are open to all LIAS PhD candidates.
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Collateral Management: more or less risk?
Jacques Sevat discussed the practical and legal aspects of global collateral management: collateral management to reduce the credit risks a global bank such as ING Bank runs every day.
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Leiden Observatory
With each discovery that is made, the universe reveals a fraction of its secrets: the most distant galaxies and quasars, the atmosphere of exoplanets, evidence of dark matter, complex molecules in space. This is what fills the days and nights of the researchers from the Leiden Observatory and their…
- The pentagonal universe of Gerard Caris
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Selectivity
Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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Invited speakers
Speakers that have accepted to participate:
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Daniela Kraft wins Biophysical Journal Paper of the Year Award
The editors of Biophysical Journal have selected a publication from Daniela Kraft’s group as the Paper of the Year 2017. The award recognizes an outstanding contribution by a young investigator.
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Millions of people to help with new synthetic skin cream
A team of researchers has managed to recreate the most natural skin cream in existence. Using the DUBBLE beamline (Dutch Belgian Beamline) at the European Synchrotron Radiation produced on the basis of the information identified, has the same properties as vernix caseosa. This cream may have a therapeutic…
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Controlling active matter with curvature
Nematic liquid crystals form the key ingredients of most tv screens. The active version of these complex fluids forms a useful model for physicists to research the responses of active matter—like bacteria or traffic flows—to mechanical and geometrical cues. An international research team publishes their…
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New insight brings sustainable hydrogen one step closer
Leiden chemists Marc Koper and Ian McCrum have discovered that the degree to which a metal binds to the oxygen atom of water is decisive for how well the chemical conversion of water to molecular hydrogen takes place. This insight helps to develop better catalysts for the production of sustainable hydrogen,…
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Leiden physicists image lumpy superconductor
High-temperature superconductivity is one of the big mysteries in physics. Milan Allan’s research group used a Josephson Scanning Tunneling Microscope to image spatial variations of superconducting particles for the first time, and published about it in the journal Nature.
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Drugs with fewer side effects through a collaboration between LACDR and PTS
LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…
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Training
As a PhD candidate, you are expected to follow certain courses and training programmes in the context of your training as a researcher. The courses and training programmes will help you conduct your research, write your dissertation, develop your career, and gain self-insight. The LACDR PhD training…
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New generation of graphene biosensors based on smooth surfaces and sharp edges
The surface and the edges of graphene are expected to provide higher sensitivity and specificity in detecting and characterizing single molecules. However fundamental physical limits exist in reaching an ultimate precision in detecting the dynamics of chemical and biological systems. The research in…
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Breakthrough in uncrackable quantum encryption
An important discovery makes it possible to communicate complex information among multiple people without the message being cracked. The communication can also relate to complex information.
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Surprising similarity between stripy black holes and high-temperature superconductors
We don’t understand how some materials become superconducting at relatively high temperatures. Leiden physicists have now found a surprising connection with auxiliary black holes. It enables us to use our knowledge of black holes on the mystery of high-temperature superconductivity. Publication in Nature…
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Searching for quasicrystals near Kamchatka
Quasicrystals are crystals with ‘impossible’ five-fold symmetries, which nevertheless were synthesized in the lab in 1982. Paul J. Steinhardt helped figure out their structure, but he didn’t stop at that.