In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

How German Jews used photographs to document their experiences in the face of National Socialism.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Research lines within the Pharmacy group:

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Research at the THEOR group is comprised of the following research themes:

The project will clarify that in the search for these new means the treatise On the sublime of ps.-Longinus played a crucial role. However, the project will also place the theatre performances in a broader social and political perspective. These public events and the theatre performances suggest that…

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

Muslims have lived in Eastern and South-Eastern Europe for centuries. Their arrival in Western Europe, the two Americas and Australia is however relatively recent. Studying how Muslims relate to their Western environment (and vice versa) and the mutual influences of Western and Islamic philosophies…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

From Incident to Precedent

Lecture

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

We would like to present to you a simple guidebook about living a sustainable life as a student in the cities of Leiden and The Hague. Whether you are a first-year student still trying to find your way around or already doing your masters – students wanting to explore more sustainable options and save…

How can the combination of sound composition, astrochemistry, and epistemological analysis provide new and unexpected insights into interstellar chemical reactivity?

How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?

Lecture

Sustainably produced food reduces CO2 emissions during production and promotes the region’s economy. The University is working to increase the number of organic, fair trade, vegetarian and vegan products in its restaurants.

The Death of Archaeological Theory, edited by John Bintliff and Mark Pearce, addresses the provocative subject of whether it is time to discount the burden of somewhat dogmatic theory and ideology that has built up over the last 25 years.

This third issue of Ex Novo gathers multidisciplinary contributions addressing mobility to understand patterns of change and continuity in past worlds; reconsider the movement of people, objects, and ideas alongside mobile epistemologies, such as intellectual, scholarly or educative traditions, rituals,…

Welcome to the |0100| blog where our team will be sharing insights from the field and contributing to the various discussions and debates around AI, Islam and scripting futures.

Promotor: Prof.dr. H.L.V. Linnartz

Objects, Appropriation and Cultural Change

Towards Health and Resilience in Volatile Environments - People differ in how they are impacted by and respond to stressful experiences. Why is that?

Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

Too big to jail?

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

The interdisciplinary AI & Society minor of Leiden University brings together students and lecturers from a wide range of disciplines. Together they look at the impact of AI on society.

Catalysts are indispensable in everyday life. We know what they do and more or less how they do it, but we still lack a fundamental understanding about their functioning at an atomic scale. Therefore, Irene Groot from the Leiden Institute of Chemistry develops new measuring techniques to unravel the…

Conference

What is Leiden University doing to make its buildings future-proof and independent of fossil energy?

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…

A full overview of MCBIM PhD theses.

Larissa Mendoza Straffon and colleagues investigated visual attentional biases toward self-made artworks, which tend to be favoured, remembered, valued, and ranked above and beyond objects that are not related to the self. Their findings confirm that attention and preference are higher for self-made…

Lecture

Promotor: H.V.J. Linnartz

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Consensus and harmony or balance and reciprocity?

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Observational, cognitive and physiological measurements in social contexts.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.