Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Reactions and reaction times in cognitive tasks.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Lecture

Catalysts are indispensable in everyday life. We know what they do and more or less how they do it, but we still lack a fundamental understanding about their functioning at an atomic scale. Therefore, Irene Groot from the Leiden Institute of Chemistry develops new measuring techniques to unravel the…

How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Mei-Wen Chen defended her thesis on 29 June 2016

Promotor: E. Bouwman, Co-promotor: S. Bonnet

How does task context affect children’s word productions?

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Lecture

How does CO adsorption on gold promote its own oxidation and the oxidation of other organic molecules?

From Incident to Precedent

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?

Everyone knows smoking is unhealthy, but did you also know that smoking is not good for the environment? In parternship with UFB, we are organising a number of action days to pick up cigarette butts, hand out sustainable ashtrays and inform people about how they can smoke more sustainably!

PhD defence

PhD defence

The project will clarify that in the search for these new means the treatise On the sublime of ps.-Longinus played a crucial role. However, the project will also place the theatre performances in a broader social and political perspective. These public events and the theatre performances suggest that…

Research lines within the Pharmacy group:

Muslims have lived in Eastern and South-Eastern Europe for centuries. Their arrival in Western Europe, the two Americas and Australia is however relatively recent. Studying how Muslims relate to their Western environment (and vice versa) and the mutual influences of Western and Islamic philosophies…

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

A full overview of BPOC/SSNMR PhD theses.

In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…

Paul Behrens and his team have won the Frontiers Planet Prize of half a million euros for their research into the effects of switching to a plant-based diet.

Lecture

This project compares and contrasts how and why several Turkish and Iranian women were compelled to participate in leftist guerilla movements in the 1960s and 1970s.

How are the building blocks of life formed?

Why does the past elicit this intense activity in the present? What does the past mean for the present, and what does it do to it? A WAR OF WORDS will engage this complex of Chinese claims to Manchu-Korean ancient history, South Korean reactions, public discourse and cultural expression in both states,…

How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?

Research at the THEOR group is comprised of the following research themes:

We would like to present to you a simple guidebook about living a sustainable life as a student in the cities of Leiden and The Hague. Whether you are a first-year student still trying to find your way around or already doing your masters – students wanting to explore more sustainable options and save…

Objects, Appropriation and Cultural Change

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Too big to jail?