This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Research at the MCBIM group is comprised of the following research themes:

The

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

Lecture

Reactions and reaction times in cognitive tasks.

Promotor: A. Doelman, Co-promotor: V. Rottschäfer

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Active-site directed probes are powerful in studies of enzymatic function. We report an active-site directed probe based on a warhead so far considered unreactive.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The probability for dissociation of molecules on metal surfaces, which often controls the rate of industrially important catalytic processes, can depend strongly on how energy is partitioned in the incident molecule. There are many example systems where the addition of vibrational energy promotes reaction…

What is the role of neuronal emotional reactivity in the intergenerational transmission of abuse?

Lecture

Lecture

How German Jews used photographs to document their experiences in the face of National Socialism.

In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.

Climate change is one of the largest challenges faced by humanity. To combat this research into alternatives to fossil fuels is ongoing. Dihydrogen is considered a good alternative fuel, since its burning only forms water.

Mei-Wen Chen defended her thesis on 29 June 2016

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

How does task context affect children’s word productions?

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The main goal of the THEOR CHEM group, headed by Prof. Geert-Jan Kroes, is to characterize, and to accurately predict the outcome of chemical reactions at gas-solid and liquid-solid interfaces. Here the solid surface is typically a metal or an ice surface. These goals are important to many areas in…

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?

Everyone knows smoking is unhealthy, but did you also know that smoking is not good for the environment? In parternship with UFB, we are organising a number of action days to pick up cigarette butts, hand out sustainable ashtrays and inform people about how they can smoke more sustainably!

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

PhD defence

PhD defence

A festive and honourable visit to our southern neighbours for professor Marc Koper. On Thursday 23 March, he received an honorary doctorate at the University of Antwerp. Koper gets the title in recognition of his expertise in the field of electrochemistry. ‘An important recognition for our research…

Paul Behrens and his team have won the Frontiers Planet Prize of half a million euros for their research into the effects of switching to a plant-based diet.

Muslims have lived in Eastern and South-Eastern Europe for centuries. Their arrival in Western Europe, the two Americas and Australia is however relatively recent. Studying how Muslims relate to their Western environment (and vice versa) and the mutual influences of Western and Islamic philosophies…

The project will clarify that in the search for these new means the treatise On the sublime of ps.-Longinus played a crucial role. However, the project will also place the theatre performances in a broader social and political perspective. These public events and the theatre performances suggest that…

Research at the THEOR group is comprised of the following research themes:

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.

Research lines within the Pharmacy group:

Both Leon Jacobse and Thom Hersbach from Marc Koper's research group obtained their PhDs cum laude. They both investigated changes on the surface of a platinum electrode. Jacobse studied this at a positive voltage, Hersbach at a negative voltage. Platinum has the potential to convert renewable energy…

A full overview of BPOC/SSNMR PhD theses.

How does CO adsorption on gold promote its own oxidation and the oxidation of other organic molecules?

From Incident to Precedent

In a full lecture hall C1 the Faculty of Science started off the new academic year on Tuesday 5 September. The theme of the meeting was, just as it had been at the university's opening the day before, sustainability.