This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

Are you interested in an interactive Master’s programme that prepares you for important roles in the innovations of our future healthcare? The Health, Ageing and Society Master’s focuses on biological, individual and social aspects of healthy ageing, as well as emphasizing on personal and professional…

Are you interested in an interactive Master’s programme that prepares you for important roles in the innovations of our future healthcare? The Health, Ageing and Society Master’s focuses on biological, individual and social aspects of healthy ageing, as well as emphasizing on personal and professional…

Begin oktober vond de eerste Psychology Connected van dit nieuwe academische jaar weer plaats. Met de vallende herfstbladeren voelen velen zich ook somberder. Onderzoekers delen hoe je een winterdepressie verzacht, en hoe je als ouder het beste kunt omgaan met de depressieve klachten van je kind.

It is important for social animals to be able to recognise one another quickly. Humans are able to recognise each other immediately from their faces. Faces are also important for chimpanzees, but a new study by neuropsychologist Mariska Kret in PLOS ONE shows that the animals' buttocks also play a…

Conference

Ukrainian President Zelensky has indicated on several occasions that he wants to be part of the European Union. According to Caroline van der Plas, Dutch MP for the BoerBurgerBeweging party, this is not possible. Any country that wants to join the EU must go through the standard procedure. No except…

Swarms of drones, pedestrians or the cells in your body. Those are all examples of active matter: materials whose building blocks can move autonomously. That’s what Luca Giomi studies. Giomi has been appointed Professor of theoretical physics in the area of soft matter and biological physics at the…

PhD defence

How to strike a balance between the sometimes conflicting stakes of individual, public and private data-producers and data-processors?

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

Huub de Groot is professor in Biophysical Organic Chemistry. With his team he works in the field of photosynthesis and artificial photosynthesis. The molecular basis for photosynthesis is formed by protein complexes and organelles that contain chlorophyll molecules. The antenna systems herein capture…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Human activity, such as pollution, may disturb the balance of living water systems, which has consequences for biodiversity, but also for other functions such as water purification. Leiden University maps living water systems using the most advanced technologies.

How do people develop and how do they learn? How does their environment affect them? How do we ensure that they develop in optimal fashion? And what can we do if problems occur? These are questions that the researchers at the Institute of Education and Child Studies try to answer.

Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…

We study the structure, dynamics and physics of complex networks emerging from the intricate interconnectedness of the constituents of large systems.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

A full overview of MCBIM PhD theses.

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

Kros

An overview of the research at the Biologics Formulation group

The researchers at the Institute of Education and Child Studies focus on child rearing and the development of children and adolescents with and without developmental and other problems, in biological and non-biological families, childcare, education and care institutions.

How do common marmosets combine their calls into sequences and how are their vocalisations influenced by reproductive state?

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

Education & outreach

The knowledge and skills you will acquire will qualify you for many different jobs. Possible careers include: researcher of learning, behavioural and emotional problems in children, or designer of prevention and intervention programmes.

How can we monitor and protect biological and cultural diversity in Suriname best? What can we learn from local knowledge and customs associated with biodiversity? How can we understand current species, acoustical, behavioural, and ecological diversity from an evolutionary perspective? Can we predict…

PhD defence

The more complex the object, the harder it is to fold up. Space satellites often need many small motors to fold up an instrument, and people have difficulty simply folding up a roadmap. Physicists from Leiden and Amsterdam have now designed a structure that folds itself up in several steps. Publication…

Water droplets float in a hot pan because of the so-called Leidenfrost effect. Now physicists have discovered a variation: the Elastic Leidenfrost effect. It explains why hydrogel balls jump around on a hot plate making high pitched sounds. Publication in Nature Physics on July 24.

Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.

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The indane (2,3-dihydro-1H-indene) ring system is an attractive scaffold for biologically active compounds due to the combination of aromatic and aliphatic properties fused together in one rigid system.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.

Supervisor: P.J.J. Hooykaas

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Source: Nature Biotechnology, Volume 2014, Issue June (2014)