550 search results for “binding studieadvies bsa” in the Public website
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‘Pretend student’? Tell others and get help
In the documentary ‘Pretend Student’, former students talk about why they let everyone believe they were still studying. How can you make sure you don’t end up in such an impossible situation? Four questions for Leiden Student Dean, Romke Biagioni, who worked on the documentary.
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Drugging the undruggable: NWO Open Competition grant for Alireza Mashaghi
Finding structure in disordered proteins and developing drugs for undruggable diseases: it might sound like mission impossible, but pharmacologist Alireza Mashaghi and his team are right on top of it. Their project was awarded by NWO through the Open Competition Domain Science -XS, a competition that…
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Research
The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Prediction of human (CNS) target site concentrations in health and disease
Prediction of human (CNS) target site concentrations in health and disease In the vision of Prof. de Lange we will only be able to predict human (central nervous system, CNS) target site concentrations and effects if we perform systematic, condition-dependent, integrative, and strictly quantitative…
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Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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How to make an old antibiotic a hundred times more potent
Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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The construction of dynasties in Habsburg Spain and Safavid Iran
How did dynastic organization – that it, the employment of non-ruling family members and the development of dynastic traditions and concepts – influence state formation in both Catholic Europe and Muslim West-Asia?
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Minerva in her Study
Following its foundation in 1575, Leiden University was quick to incorporate Roman goddess Minerva in its coat of arms. This explains why Rembrandt’s Minerva from 1635 can be seen on the façade of the Academy Building, which has been in use by the University since 1581. This is where, in the Senate…
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The immune system in action against cervical cancer
In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.
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The Acquisition of Personal Pronouns in Cochlear-Implanted Children
This dissertation examines whether a cochlear implant provides congenitally deaf born children with sufficient auditory input to acquire low salient and syntactically and semantically complex functional items such as personal pronouns compared to their hearing peers.
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Strengthening the EU’s Response Capacity to Health Emergencies: Insights from EU Crisis Management Mechanisms
Despite an increased EU role in the preparedness, monitoring and coordination of health emergencies over the past two decades, Member States’ responses to the first wave of COVID-19 were surprisingly uncoordinated. In light of calls to improve cooperation regarding future health emergencies, this article…
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Medicine
The Faculty of Medicine
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Receptor Residence Time
Research question
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Proteochemometric modelling coupled to in silico target prediction
An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.
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Research
LUCAS members are experts in the fields of literary history and theory, film and media studies, and art, architectural, and book history.
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Optogenetic activation of intracellular adenosine A2A receptor signaling in the hippocampus is sufficient to trigger CREB phosphorylation and
Source: Mol Psychiatry (2015)
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Zwitterionic oligosaccharides: charging the immune system
How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?
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Key publications
Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)
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Limiting Viral Spread: Automated Cyber Operations and the Principles of Distinction and Discrimination in the Grey Zone
Monica Kaminska, Dennis Broeders and Fabio Cristiano have contributed a chapter to the proceedings of the 13th International Conference on Cyber Conflict (CyCon 2021), which gathers 20 articles from the law, technology and strategy domains.
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Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
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Matching Module
Participation in the matching module is a compulsory part of the admission and application procedure for all applying students of this programme.
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Compulsory matching
BSc Cultural Anthropology and Development Sociology is a bachelor’s programme with a compulsory matching module.
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Matching Module
Participation in the matching module is a compulsory part of the admission and application procedure for all applying students of this programme.
- Workshop: Arabic manuscripts and how to read them (Two-day introductory workshop)
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Laura Heitman appointed as Professor of Molecular Pharmacology
As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…
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Open Consultation on UN GGE 2015 Norm Proposals
The Leiden University’s Program for Cyber Norms, a research platform to investigate the development and implementation of law and policy applicable to uses of ICTs, in cooperation with the think-tank ICT4Peace conducted a global open consultation on how to implement the UN Group of Governmental Experts’…
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Superselective bonds light up
Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researchers first caught this phenomenon using spheres or colloids, and published…
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Laura Heitman uses her expertise to fight cancer
Seven talented female scientists join the fight against cancer of the Oncode Insitute. Laura Heitman of the Leiden Academic Centre for Drug Research is one of the new Junior Investigators. ‘I hope to discover new druggable targets’.
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Rethinking drug discovery: Vidi grant for Laura Heitman
Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.
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Fossil Fuel Industry (ab)uses the Legal System: The Urgent Call for Binding Regulations to Protect People and Climate
Debate, Roundtable discussion
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'I like that students trust us and share their stories with us'
The student navigator 'Find your way' helps students find their way around the university. Student advisers can also be found on the roadmap. JanPieter, student advisor at the Institute of Security and Global Affairs (ISGA), explains what a student advisor does.
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Using a camera to look into a book's spine: ‘You might just find that one rare text’
What do you do if you have a book from the sixteenth or seventeenth century, but you suspect that the binding contains a fragment of a medieval manuscript? University lecturer Thijs Porck has received an NWO grant to experiment with a camera attached to a tube. 'The project boils down to keyhole surgeries…
- Economic, Corporate, Commercial & Trade Diplomacy
- US Diplomacy
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Metals for Catalysis and Sustainability
Central in coordination and organometallic chemistry is the synthesis of new chelating ligands, the synthesis and characterization of metal complexes with these ligands, and the study of their properties. An important goal in my research is to create understanding of the relation between the structures…
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Movements of steroid receptors inside the cell nucleus unraveled
Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.
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Which antibodies are most effective against coronavirus?
Researchers Indu Khatri, Frank Staal and Jacques van Dongen from Leiden University Medical Center (LUMC) have published a perspective article in Frontiers in Immunology about coronavirus and its characteristic ‘spike protein.’ They predict which antibodies would provide the best protection against the…
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Modified caffeine molecules help medical research move forward
Before researchers can develop targeted drugs, they need to know exactly how a disease works. Biochemist Bert Beerkens created molecules that allow them to find out. He used caffeine as the basis for new molecules that enable research into certain receptor proteins on cells.
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EU JudgeCo Project
This project aims to design Principles and Guidelines to improve coordination between courts in Europe for insolvency and related proceedings.
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Leiden Institute of Advanced Computer Science
Digital technology is changing academia and society at lightning speed. LIACS is in the midst of this with groundbreaking research into data processing and artificial intelligence (AI). It conducts a unique combination of fundamental and applied research into major issues facing academia and society…
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Colloidal LEGO with peptides
Kros
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Key publications
Key publications of the Predictive Pharmacology group.
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Written Culture at Ter Duinen: Cistercian Monks and their Books, c.1140-c.1240
The physical features of twelfth-century manuscripts from the Flemish abbey of Ter Duinen – such as script, page layout, and reading aids – show how their readers organized, interpreted, and transmitted knowledge.
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Legal Risks in EU Law
This book presents concrete solutions for managing the legal risks distorting the development of various areas of EU law. It pursues an innovative and effective approach to identify legal risks, their causes at the EU level and their impacts on the functioning of the Union and its Member States. It…
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Research
Research at the SBC group is comprised of the following research themes:
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PhD Theses
A full overview of MacBio PhD Theses.
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Canonical Cultures network
Religion, Philosophy, and the Pre-modern World
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City Deal Kennis Maken: Leren met de Stad Leiden
Hoe kan de City Deal Kennis Maken bijdragen aan het formuleren van maatschappelijk relevant onderzoek dat de stad in al haar diversiteit centraal stelt? In de stad Leiden zijn burgers momenteel maar in beperkte mate betrokken bij het bepalen van de agenda van de lokale City Deal Kennis Maken. Dit onderzoeksproject…