Leiden University social scientists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

Neural networks have a wide range of applications. In Leiden, psychologists use them to build robot brains, whereas archaeologists use them to hunt for prehistoric graves.

Leiden University neuropsychologists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

Nederland heeft geen nationale bloem en daar wil het radioprogramma Vroege Vogels verandering in brengen. Verschillende experts van Universiteit Leiden zijn betrokken bij de verkiezing.

Op woensdag 12 oktober worden vier lezingen gehouden over een opmerkelijke verzameling aantekenboekjes uit de vroege elfde eeuw, thans bewaard in Leiden. Ze zijn vervaardigd door de Franse monnik Ademar van Chabannes. Ad van Els schreef er een diepgravende studie over: A Man and his Manuscripts. De…

This project, under the supervision of Prof. Dr. Hans van der Plicht, comprises several studies aimed at the use of isotopes occurring naturally in organic material as tracers for both the climate change and its cultural impact at about 6200 BC. The research will be carried out by the co-applicant at…

This project employs a systematic experimental approach to examine the interaction of these two hitherto independent lines of research (tone sandhi and focus realization) in six dialects of Chinese, which lie on a continuum between dialects with dense tonal distributions and sparser distributions. In…

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

How can zebrafish research help understanding human diseases?

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

Lecture, Research Seminar

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn, Co-promotor: Dr. M.J.M. Schaaf

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: M. Danhof Co-promotor: O.E. Della Pasqua

Promotor: M.A.G.J. Orrit

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

On the 6th of November, Virginia Beavon Ham successfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Virginia on this achievement.

What motivates people to provide help to, or seek help from other groups? And what are the psychological consequences of receiving help from another group?

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Measurement of brain activity by external electrodes (EEG).

The China Region Group develops and monitors Leiden University's cooperation with China. It is chaired by the Dean of the Faculty of Science, Prof. Jasper Knoester, and consists of representatives of Leiden University's faculties and various policy departments.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

On April 26th, Kate Bellamy succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Kate on this great result.

Promotor: Prof.dr. A. Achucarro

In this 3-volume set of primary sources, Lionel Laborie and Ariel Hessayon bring together a wide range of vital sources for the study of prophecy in the early modern world. This meticulously edited collection includes rare material and fascinating manuscripts published in English for the first time.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

What is the role of emotion regulation in coping with interpersonal feedback?

Our cantilevers have a low intrinsic damping rate: this enables us to measure with low noise, since damping is proportionate to noise. However, when the magnet is close to the surface of a sample we want to study, we measure a much higher effective damping rate. This is caused by magnetic interaction…

Implementation of the new sound synthesis and analysis method in music composition.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.