A common assumption in chemistry is that the coordination number of a catalyst's surface determines the reactivity of the reaction it catalyses. Strikingly, Leiden chemists have now proven that this is not true for nature’s most simple chemical reaction: the dissociation of hydrogen. The researchers…

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

Last year, chemists Dennis Wander and Hermen Overkleeft contributed to an important discovery about a widely used cancer drug. Their research has now been recognised as Finalist for the PNAS Cozzarelli Prize in the Biomedical Sciences class.

Quantum hardware comes with a different computing paradigm and new ways to tackle applications. Much effort has to be put into understanding how to leverage this technology to give real-world advantages in areas of interest for industries such as combinatorial optimization or machine learning.

Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

This research focuses on figurative Byzantine mosaic-floors that have been excavated in the geographical area of the ancient provinces of Palestina and Arabia (current Israel, PA and Jordan) dating to the Late 5th, 6th and early 7th centuries C.E.

In January 2014, the research project The Promise of Organization hosted a fruitful three-day conference:

On March 27th, 2015 the biannual Dutch Medicinal Chemistry Prize for the best Dutch Ph.D. thesis in the field was awarded to Dr. Dong Guo, a current postdoc researcher in our lab, by the Section of Medicinal Chemistry of the Royal Netherlands Chemical Society.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

PhD candidate Dennis Wander searches for the best of both worlds. That is to say: a cancer drug that is effective and also has minimal side effects. To this end, he makes new molecules inspired by two existing medicines. And not without result: ‘We have created a new variant that is very promising.’…

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

The project re-examines the role of the Catholic, Protestant and Orthodox missionaries in the cultural and social developments of the Middle East and their interactions with the indigenous communities, from the nineteenth century until today. It seeks to discover and retrace such ‘entangled histories’…

The aim of this thesis is to study cell-cell interactions and the development of an assay to explore and quantify the exchange of membrane compounds.

The European Council and the European Commission have a similar role in agenda setting. Both place issues on the EU agenda. However, these institutions have distinct designs. They have different political attributes (the European Council has considerably more political authority) and information-processing…

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

Alumnus Vincent Renken studied Bio-Pharmaceutical Sciences in Leiden and is now co-founder of an outdoor escape room company. ‘I asked myself: do you want a standard life or an adventure?’

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

Leiden Professor of Molecular astrophysics Ewine van Dishoeck has been awarded an Advanced Grant by the European Research Council (ERC). She has been awarded 2.3 million euros in research funding for the MOLDISK programme. Within this programme, Van Dishoeck wants to connect chemistry and physics in…

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

The organ in the Academy Building is 25 years old. University organist Jan Verschuren and tuner Bert Crama talk about the long history of university organs, improvising with short cortèges and their love for this organ.

On the occasion of the Women & Girls in Science Day, BBC Science Focus Magazine highlighted 6 prominent female chemists. Among them is Leiden professor Ewine van Dishoeck: 'Astrochemist investigating the building blocks of life'.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

PhD defence

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

A conference organized by Niels Blokker, professor of International Institutional Law and Ramses Wessel (RUG) to celebrate the 20th anniversary of the International Organizations Law Review.

Lecture

Cyclic peptides are investigated as a platform to induce different orientations between various ligands.

An objective of this research was to achieve direct, well-defined and non-rate-limiting electron transfer between respiratory enzymes and the electrode surface by means of 'Q-wires'.

On September 30, 2022, our esteemed former colleague Gerrit Lodder passed away from the effects of Parkinson's disease. He leaves behind his wife Adry, his sons Gert-Jan and Michiel, his daughters-in-law Annerieke and Manyana and grandchildren Annelot and Gijs in sadness, but also in the knowledge that…

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

Although Sander Wezenberg just started working in Leiden in March this year, he already managed to win a Vidi grant from NWO. Inspired by nature, Wezenberg wants to bring synthetic molecules to life and teach them to communicate. But who exactly is Wezenberg and what drives him?