Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

PhD defence

PhD defence

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

This book, edited by Joost Augusteijn, Constant Hijzen and Mark Leon de Vries, explores how democratic regimes have dealt with anti-democratic forces in society, from the late nineteenth to the early twenty-first century.

Last November, it was announced that the European Commission has awarded a Jean Monnet Chair to Professor of Tax Law Irma Mosquera Valderrama. She will use the grant to shape the EUTAXGOV project over the next three years.

Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.

The Ministry of Home Affairs and Kingdom Relations (BZK) is establishing two new professor chairs for the Kingdom.

LUCIS is directed by Nathal Dessing, who is advised by a steering committee.

Jonathan Todres appointed as Rotating Honorary Chair in Enforcement of Children’s Rights 2024/2025

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.

Dr Anouk Goemans has been appointed professor by special appointment of Youth Services and Child Protection from an Educational and Legal Perspective as of 1 November 2024. This chair is funded by the 'Stichting Steunfonds Pro Juventute' support fund foundation and serves as a bridge between the Department…

When we talk about the Kingdom of the Netherlands, it is not just about the Netherlands. On the contrary: our Kingdom consists of no less than four countries, three of which are Caribbean islands. This structure is complex, to say the least. Although all countries are officially equivalent, in practice…

Leiden University’s Executive Board has appointed South African Professor Ann Skelton as the new Chair of Children’s Rights in a Sustainable World as of 1 October 2022.

The Executive Board and Management Board of the EU Fundamental Rights Agency will meet from 13 to 15 December, with Rick Lawson as Acting Chair.

On Saturday 17 November 2018 Vestert Borger chaired a panel at the conference ‘The EMU at Twenty’.

On 1 October 2024, Dr Jiska Engelbert was appointed as professor by special appointment on the Ien Dales Chair ‘Government as an Employment Organisation’. Her focus is on leadership in digital transitions, digital innovations, and the transformation of public services, with particular attention to local…

Dr Moritz Jesse, European Institute at Leiden Law School, has been awarded a Jean Monnet Professorship. From November 2023, Moritz will teach bachelor's and master's courses as part of his ‘Migration, Integration, Non-Discrimination in the EU’ project [MIND-EU]. At a later stage, Jesse’s Jean Monnet…

Sofia Ranchordas (1985) has been appointed Chair European and Comparative Public Law and Rosalind Franklin Fellow at the University of Groningen. She will start this position on October 1st.

22 September 2017 the second biannual conference took place organised by IAAEU of the University of Trier and the Hugo Sinzheimer Institute of Frankfurt. The theme of the conference was the European Pillar of Social Rights. Under the heading of the conference’s title, International Labour Law as a stimulus…

Prof. dr. ir. Bas Rietjens of the Dutch Defense Academy (NLDA) has been appointed Professor by special appointment Intelligence in War and Conflict at Leiden University’s Institute for Security and Global Affairs (ISGA). The appointment of Rietjens is the result of a more intensive collaboration between…

Professor Ann Skelton has been elected as Chairperson of the United Nations Committee on the Rights of the Child.

On 1 December 2023, Fatma Çapkurt was appointed as deputy chair of the State Committee on the Rule of Law.

The Europa Institute is delighted to announce the appointment of Freya Baetens to the Chair in EU External Economic Law.

A study has been initiated at the instigation of WODC (Scientific Research and Documentation Centre) on the judicial monitoring of big data applications by government. The study is being conducted by TILT (Tilburg Institute for Law, Technology, and Society).

Nico Schrijver, Professor Emeritus of Public International Law, has been appointed Interim Chair of the Netherlands Institute for Human Rights. He will take up the position on 1 July 2024.

The Pension Funds Dispute Authority (GIP) was founded on 1 January 2024. Albert van Marwijk Kooy has been appointed Chair of the Dispute Resolution Committee, which forms part of the GIP.

In the light of today’s major changes and challenges, the congress on November 22 will focus on Redesigning the Designer while also taking some of the examples of more-than-human knowledge experimented with within Neuhaus as a starting point for a new network.

On November 23, 2017, Professor Simone van der Hof chaired a panel on age verification in the digital world at the Safer Internet Forum 2017 in Brussels.

Those who seek justice do not always manage to find their way through the legal system. Yet the Dutch Legal Aid Act assumes that citizens are self-reliant and can stand up for their interests in cases that are not legally complex. However, in the childcare benefits affair in the Netherlands, this proved…

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Synthetic cells, also known as artificial cells or protocells, have wide ranging applications from drug delivery vectors to cell models. In biotechnology they can function as micro- or nanoreactors with possible applications in biocatalysis and photocatalysis. Phospholipids are by far the most commonly…

Leiden University will appoint Dr Anne-Laura van Harmelen as Professor of Brain, Security and Resilience at the Institute of Education and Child Studies with effect from 1 September 2020. She will focus on the brain in relation to the development of transgressive behaviour and its prevention and tre…

Prof. dr. Arnold Tukker will be appointed on 1 October 2013 as Chair of Industrial Ecology at the Faculty of Science of Leiden University. He will work at the Institute of Environmental Sciences (CML), and also become the new director of this institute.

The Roosevelt Chair in New Diplomatic History is sponsored by the Roosevelt Institute for American Studies (RIAS) in Middelburg, and the new position further strengthens the connection between the RIAS and Leiden.

On Thursday 24 November 2016 Moses George will defend his PhD dissertation ‘Legal Implications of Airport Privatization in India’. The defence will commence at 11.15 hrs, in the Academy Building of Leiden University. The Supervisors are Professor Pablo Mendes De Leon and Professor Brian F. Havel (DePaul…

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

Cardiovascular diseases are still a major concern for the global health.