208 search results for “kinase inhibitors” in the Public website
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Miraculous mechanism allows plant cells to directionally distribute the growth hormone auxin
Leiden and Austrian researchers have succeeded in further uncovering how a plant cell passes on the growth hormone auxin in a directional manner to the next cell. Three proteins that cling together in a bunch appear to be essential for this important transport process. ‘This discovery solves a crucial…
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Halting protein degradation may contribute to new cancer treatment
Chemist Gerjan de Bruin has designed a method of slowing down the degradation process of proteins in cells. This may contribute to new cancer medicines with fewer side-effects. PhD defence on 1 June.
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PhD Theses
A full overview of MacBio PhD Theses.
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More effective blocking of CCR2 receptor
The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…
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Hit Discovery
The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.
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Do internationally adopted children in the Netherlands use more medication than their non-adopted peers?
Adoptees in the Netherlands generally do not use more medication than their non-adopted peers.
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Respiratory-chain enzymes
Many metalloenzymes that are key to bioenergetics are membrane enzymes, with canonical examples the complexes I, II, III and IV in the mitochondrial inner membrane. To study these enzymes in a native-like lipid membrane environment, we aim to develop novel bioelectrochemical techniques.
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Chara
The Green algae Chara as model system for intra and inter cellular transport processes.
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The scientists behind LED3
LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.
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Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
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Cancer Therapeutics and Drug Safety
In this research group, headed by Bob Van de Water, cell signaling programs that underlie adverse drug reactions as well as cancer development and progression are unraveled. Adverse drug reactions involve cell injury in critical target organ cells which leads to the activation of cellular stress response…
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KNMP student prize for Bio-Pharmaceutical Sciences student Jacqueline Gerritsen
During the congress of the Royal Dutch Association for the Advancement of Pharmacy (Koninklijke Nederlandse Maatschappij ter bevordering der Pharmacie, KNMP) Jacqueline Gerritsen, former student Bio-Pharmaceutical Sciences at Leiden University, was awarded the KNMP student prize.
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‘How can we translate the language of cells into cancer therapies?’
On 23 April 2021, Professor Alfred Vertegaal from the Department of Cell and Chemical Biology at the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Unraveling and exploiting cellular communication codes’. Vertegaal used the opportunity to describe how research in the field…
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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The EPIC Alliance joins forces to combat antibiotic resistance
No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.
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Annelot van Esbroeck wins Best Oral Communication Prize
Annelot van Esbroeck-Weevers, PhD student at the Molecular Physiology research group at the Leiden Institute of Chemistry, headed by Dr. Mario van der Stelt, has been awarded the Best Oral Communication Prize at the 8th European Workshop on Cannabinoid Research, held from 31 August to 2 September 2017…
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Awards and Grants 2018
An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.
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Zhiyi Yu - winner of LACDR Spring Symposium
Zhiyi Yu was elected as the winner of the annual PhD Competition at the LACDR Spring Symposium on June 17th 2014.
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ERC grant to improve post-vaccination protection in low-income countries
Maria Yazdanbakhsh, Professor of Parasitology at the Leiden University Medical Centre (LUMC), has been awarded an ERC Advanced Grant of 2.5 million euros. She will investigate why people in Africa and Southeast Asia respond less to certain vaccines than Europeans. Her goal is to find a solution for…
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EU awards 18 million euros for research into new antibiotics
An international consortium of research groups is aiming to develop novel antibiotics against the tuberculosis bacteria and two other deadly bacteria. The European Union has awarded a total of 18 million euros to the RespiriTB and RespiriNTM projects. Researchers from the Leiden University Medical Centre…
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Education highlights 2023
From educational adventures in the tropics, students building software for real customers, to bacteria that degrade plastics. Scroll through our highlights on educational innovation and the achievements of our students.
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Discovering and developing drugs
Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Remko Offringa appointed Professor in the field of Plant Developmental Genetics
Remko Offringa has been appointed Professor in the field of Plant Developmental Genetics within the Faculty of Science at the Institute of Biology Leiden (IBL) from the 1st of April 2017. Offringa’s research focuses on the role of the plant hormone auxin in controlling plant growth and development,…
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Marc Baggelaar graduates cum laude on body’s own marijuana
PhD candidate Marc Baggelaar of the Leiden Institute of Chemistry (LIC) graduated cum laude on Thursday 6 April. His thesis on the endocannabinoid system in the brain is very comprehensive and of high quality, according to the jury. ‘A very talented young scientist, that definitely belongs to the top…
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Aggressiveness of cancer cells halted
Zebrafish-human communication shows that cancer cells lacking a signaling protein are less able to develop aggressive metastatic properties. This discovery has been made by molecular cell biologist Claudia Tulotta. PhD defence 14 June.
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Double success at the EMBL Chemical Biology Conference
Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.
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Freek Janssen wins award for best European Young Medicinal Chemist
Freek Janssen, a PhD-student in the department of Molecular Physiology, has received an award for the best oral presentation during the Young Medicinal Chemist Symposium organised by the European Federation of Medicinal Chemistry (EFMC-YMCS’16). Freek Janssen presented his work on “Development of Highly…
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LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Support the LUMC’s corona research
Scientists at the LUMC are working hard on potential virus inhibitors, antiviral screening and a treatment for COVID-19. SteunLeiden.nl has started a crowdfunding campaign for this research, under the hashtag #wakeuptocorona. Professor of Virology Eric Snijder explains why this is desperately needed…
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Carbohydrate chemistry champion: Hermen Overkleeft claims prestigious award
Professor Hermen Overkleeft has received the esteemed Roy L. Whistler International Award in Carbohydrate Chemistry for 2024 by the International Carbohydrate Organization. The award recognises Overkleeft’s outstanding contributions to the field of carbohydrate chemistry and biochemistry.
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Screening enormous databases to find a cure for cancer
Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’
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Cells with stress: predicting drug-induced liver and kidney damage
How can we prevent drug-induced liver and kidney damage? PhD candidates Marije Niemeijer and Lukas Wijaya investigated what happens in the cells during the onset of this damage: a stress response. Both focused on a different subtopic and made some interesting discoveries.
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Rubicon grant for four Leiden researchers
Four promising young researchers from Leiden University have received a Rubicon grant from the Dutch Research Council (NWO). This grant will enable them to gain valuable research experience at top universities abroad.
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Using AI to Combat Drug Resistance - an Interview with PhD student Rosan Kuin
Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…
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Awards and Grants 2023
On this page you will find an overview of awards and prizes granted to our staff and students in 2023, as well as special appointments at Leiden University and other institutions.
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Cognition in the digital environment laboratory
To develop a new generation of brain science (and train scientists) focused on explaining complex real-world behavioural patterns.
- Publication highlights
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ERC Synergy Grant to unlock sugar codes for health and a sustainable society
Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…
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Mosaic subsidies for highly talented ethnic minority researchers
Four of Leiden's young, talented ethnic minority graduates are to receive an award as part of the Mosiac programme of the Netherlands Organisation for Scientific Research (NWO). The award will allow these budding researchers to fund a four-year research period leading to a doctorate.
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New zebrafish study to understand human cancer
Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.
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Blog post: The nose of this wormy-shaped bacterium has a surprising symmetry
For the first time ever, Leiden biologists have found that the ‘nose’ of spirochetes – worm-shaped bacteria – have a two-fold symmetry. A remarkable discovery, as the ‘nose’ of every other bacterium has been found to have a six-fold symmetry. First author Alise Muok wrote a popular blog about the findings…
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Veni grants for 21 researchers from Leiden University
An impressive 21 research projects by Leiden researchers have been awarded Veni funding from the Dutch Research Council (NWO).
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LIC Lecture + drinks
Lecture
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Hebben reumapatiënten met hulp van placebotechnieken minder medicatie nodig?
From painful joints to intense fatigue: a third of rheumatism patients suffer serious effects from this chronic condition and rely long-term on medication. Leiden psychologists are to receive a subsidy from the Netherlands Arthritis Foundation to investigate whether placebo techniques can help patients…
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Brand-new professor Gerard van Westen wants to cross boundaries
Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…
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LIC Lecture: To Eat or Not To Eat: Leveraging Chemical Proteomics for the Study of Macrophage Phagocytosis
Lecture