550 search results for “binding studieadvies bsa” in the Public website
-
Calcium-dependent regulation of auxin transport in plant development
The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).
-
Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
-
Freedom of additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
-
Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
-
NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
-
Applications of paramagnetic NMR spectroscopy for protein research
The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.
-
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
-
3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…
-
Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
-
Exploring and exploiting the mechanism of mycelial pellet formation by Streptomyces
Promotor: G.P. van Wezel
-
How partisan politics influence government policies in response to ageing populations
Kohei Suzuki is Assistant Professor at Institute of Public Administration. This study carries several important implications for understanding the policy impacts of a graying population and for studies of the welfare state, in general.
-
Academic Integrity & Ethics Review
Scientific integrity is an essential element in the PhD trajectory and is addressed in several different settings.
-
Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
-
Medieval and Early Modern Studies (c. 600-1800)
This research cluster explores processes of cultural creation, reception and transformation within a wide range of societal contexts from the early Middle Ages until c. 1800.
-
Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
-
Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
-
Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
-
In silico characterization of a GPCR focused library
Supervisor: Gerard van Westen
-
Making the invisible visible: paramagnetic NMR and the transient protein complex
Promotor: Prof.dr. M. Ubbink
-
Design and development of conformational inhibitors and activity-based probes for retaining glycosidases
Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.
-
Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
-
Chemical reactivity of O2, CO and CO2 on Cu surfaces
Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.
-
About the programme
The tree-year bachelor's programme in Archaeology is a many-sided programme in which you study societies, cultures, and human behaviour from the past, aiming to reconstruct and revive them. Dive into the development of human societies all over the world, from the Americas to the Middle East, from the…
-
Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: E. Bouwman, Co-promotor: S. Bonnet
-
A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
-
How to scale clearance from adults to children for drugs undergoing hepatic metabolism?
The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.
-
FitDis!
FitDis! is designed to ease the determination of binding energy and oligomeric state of coiled coil peptides. It allows direct fitting of concentration dependent thermal peptide unfolding curves measured for instance by CD–spectroscopy.
-
The High Representative in Bosnia-Herzegovina: The Unusual Institutional Arrangement of a Non-Authoritarian, Yet Controlled, Democracy
In this article, Gerrit Dijkstra and Jos Raadschelders from the Institute of Public Administration, argue that Bosnia-Herzegovina survives so far on the basis of negative legitimacy.
-
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model
-
Thomas Schmidt Lab - Single Molecule Microscopy
Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.
-
Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.
-
Drug Discovery & Safety
In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.
-
Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
-
Direct and two-step activity-based profiling of proteases and glycosidases
Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel
-
Author, Reader, Book: Medieval Authorship in Theory and Practice
This collection brings into conversation several kinds of scholarship on medieval authorship which have tended to remain separate over the last two to three decades, a period of steadily increasing scholarly interest in this topic.
-
Understanding functional dynamics and conformational stability of beta-glycosidases
Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.
-
Redox Interconversion between Metal Thiolate and Disulfide Compounds
In the last decade, the redox interconversion between metal thiolate and disulfide compounds has been extensively investigated for copper, but not for other transition metal ions.
-
Dynastic Juniors in Europe and Asia
Subproject of
-
Unveiling the invisible conformational landscape of cytochrome P450
.
-
The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law
On 23 juni 2019, Zygimantas Juska defended his thesis 'The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law'. The doctoral research was supervised by Prof. dr. T.R Ottervanger.
-
Books and films
Leiden University has made history with its many scientific discoveries; a history that is also illustrated in a variety of books and films.
-
Structure-affinity relationships (SARs) and structure-kinetics relationships (SKRs) of Kv11.1 blockers
Source: J Med Chem (2015)
-
Public service professionals coping with contrasting demands
Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?
-
Guidance documents of the European Commission in the Dutch legal order
On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).
-
Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
-
Career Services
Do you want to make contact with talented young people at an early stage of their career? Career Services can help you can get in touch with students and young alumni of Leiden University.
-
Van Marum Colloquium: Concerted Cation-Electron Transfer at Pt(111)/Perfluoro-Sulfonic Acid Ionomer Interface
Lecture
-
Sentiment Shifts and a New Approach to Strategic Narratives Analysis: Russian Rhetoric on Ukraine
This article assesses Russian rhetoric toward Ukraine from 2004 to 2019 by analyzing statements by the Russian Ministry of Foreign Affairs.
-
Affinity
Designing and synthesizing high-affinity ligands for a given drug target have always been among the more important challenges in the drug discovery process.
-
About the programme
The curriculum of this bachelor’s programme gives you an understanding of artificial intelligence and data science with a solid basis in computer science. Both artificial intelligence and data science are broad disciplines that require essential and foundational underpinnings.