236 search results for “bacterial” in the Public website
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Bacteria inside plant roots battle fungal disease
Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…
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Student team iGEM Leiden wins gold in Boston
The adventure of iGEM Leiden has come to an end. The result: prizes for Best Therapeutic Project and Best Model, a gold medal, a successful crowdfunding campaign and of course their open-source research findings, which are available for the scientific community.
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Deadly infections on the increase: urgent need for new antibiotics
Globally, the number of deaths from infections is on the rise as more bacteria become resistant to antibiotics. New classes are desperately needed. A promising resistance inhibitor is now being developed by the research group of Nathaniel Martin, Professor of Biological Chemistry. Inaugural speech on…
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Leiden University and LUMC join Netherlands Centre for One Health
Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.
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Status update in the evolutionary race between humans and resistant bacteria: two steps forward for us
A patent for what may be a potent, new antibiotic. And: a clear overview of promising approaches to overcome a crucial resistance tactic employed by bacteria. In the span of one week, two researchers from Leiden are receiving their PhDs, each of them on an important step in the battle against bacteria…
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Awards and Grants 2020
An overview of awards and prizes granted to our staff and students in 2020, as well as special appointments at Leiden University and other institutions.
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NWO awards curiosity-driven research Ariane Briegel with grant
Professor of Ultrastructural Biology Ariane Briegel has received a grant in the NWO Open Competition Domain Science in the XS category. This grant emphatically encourages curiosity-driven and bold research with a maximum of 50,000 euros.
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SBB team wins Philips Innovation Award
On Monday May 8th, two Leiden Startups took part in the finals of the Philips Innovation Awards. One Leiden venture, Levels Diagnostics, was selected as the winner of the €10.000,- price in the category of ‘Rough Diamonds’.
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ENW grant from the Dutch Research Council (NWO), Oct.30 2023
“Is it possible to restore antibiotic sensitivity in resistant bacteria?” Dr. Tingjie Guo wondered. “Watch me and learn”, phage responded. Dr. Tingjie Guo received an open competition XS domain ENW grant from the Dutch Research Council (NWO) to investigate the evolutionary trade-off of antimicrobial…
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Scientists discover how to improve the production of antibiotics and enzymes in soil bacteria
A team of researchers at the Institute of Biology Leiden, in collaboration with scientists from Utrecht University, has discovered a novel approach to improve the production of antibiotics and enzymes in the soil bacteria Streptomycetes.
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NWO-grant for degration of biomass
Dr. Erik Vijgenboom (IBL) and Dr. Peter Punt (IBL/TNO) obtained a new NWO-grant for their project FILAZYME to develop filamentous micro-organisms for enzyme production to degrade biomass.
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Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).
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Overview
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterise and predict variation in treatment response and enhance translational drug development strategies.
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‘But how many bacteria live on my hands, then?’ Micro-day in photos
From 22 to 24 October, researchers of the MARBLES-project informed museum visitors about microbes: bacteria and fungi that live all around us. The event was organised around the Micro-day of Leiden, which is this year’s EU City of Science.
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Ariane Briegel appointed as Medical Delta professor
Yesterday, eight professors were simultaneously inaugurated as ‘Medical Delta professor’, at Leiden University, LUMC, TU Delft, Erasmus University and Erasmus MC. Ariane Briegel, researcher of the Institute of Biology Leiden of Leiden University, also received the double appointment.
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New dimension to coral research
For the first time, international researchers have mapped the network of bacteria on coral reefs. They write about it in Nature Communications (9 April). Professor by special appointment Nicole de Voogd (Naturalis Biodiversity Center & Institute of Environmental Sciences) and two of her PhD students…
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Can we make bioplastics with artificial photosynthesis?
Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…
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Proteins and DNA loops: Science-Groot grant for Remus Dame
How do our cells keep DNA stored away? To find out, biochemist Remus Dame received a 3 million euro Science-Groot grant. Leiden University will share the grant with TU Delft, VU Amsterdam and the Hubrecht Institute.
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Innovative Leiden research receives NWO grant
On January 24 Professor Annemarie Meijer and Dr Sander Wezenberg received a NWO grant for their research. The grant was awarded within the Open Competition Domaine Science-M programme and is intended for innovative research areas that can form the basis for the research themes of the future.
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New insight into tuberculosis infection
Michiel van der Vaart with a team from Leiden University and the LUMC, led by IBL-researcher Annemarie Meijer, discovered that DRAM1 is a protein that regulates anti-bacterial autophagy, a defense mechanism against infections such as tuberculosis.
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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Medical Delta professor Ariane Briegel: 'I love working with people from different backgrounds'
Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…
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Researchers discover hitchhiking bacteria
Imagine that you need to travel, but you don’t have a car and you’re dead broke. What do you do? Hitchhiking, of course! Leiden biologists found that certain bacteria use this very same tactic: their spores hop on motile bacteria and use them as a taxi, ensuring they reach the right environment to f…
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Leiden University strengthens its focus on Chemical Biology and Medicinal Chemistry with seven new group leaders
Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…
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Niko Tinbergen lecture 2019: Stem cells, mini organs and eternal life
Three speakers, three fascinating science stories and a well-filled lecture hall. The Niko Tinbergen Lecture had a successful restart on 10 December 2019.
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NEXUS1492 study on ancient human microbiomes published in Nature Scientific Reports
An international team of researchers, involving members from the ERC Synergy project NEXUS 1492 based at the Leiden University, the Universities of Oklahoma, Copenhagen and York reveal challenges when studying ancient microbiomes in a recent issue of Scientific Reports.
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From droplets in the freezer to the inception of a potent new antibiotic
What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…
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Powerful new Leiden 'super antibiotic' may overcome resistance
The prestigious journal Science Translational Medicine has published a study by researchers from the Institute of Biology Leiden (IBL) on a potent new antibiotic that can overcome resistance. ‘The idea was to tweak the original antibiotic and create a next-generation drug’, says Nathaniel Martin, professor…
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Leiden biologists get awarded 730k NWO grant
Salma Balazadeh, Víctor Carrión, and Jos Raaijmakers, biologists at the Institute of Biology Leiden (IBL), have successfully applied for an NWO grant and got awarded 730.000 euros. The board of NWO Domain Applied and Engineering Sciences awarded funding for their project within the Open Technology Programme…
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“Kees Bakker" award for Bregje Brinkmann
Leiden Biology student Bregje Brinkmann received the annual award for being the best BSc-student in 2014 from the “Stichting Professor Dr. K. Bakker-fonds”.
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Fifty Shades of Stress
The challenge: Building a tool to detect chemical compounds that individually cause non-lethal stress to bacteria, but that are lethal in combination. A team of thirteen Leiden students are taking up this challenge in the annual ‘international Genetically Engineered Machine’ (iGEM) competition for applications…
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Soil bacteria can produce a wealth of new antibiotics
Soil bacteria can produce a wealth of antibiotics that are new to us, claims Gilles van Wezel, Professor of Molecular Biotechnology at the Institute of Biology Leiden. His research group has developed a method that can rapidly identify and produce these unknown compounds.
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Opening PoreLab
PoreLab is officially opened on November 1st, 2016. This new lab located at the Sylvius Laboratory will be working with the latest DNA analysis technology and will bring science, education and industry together to explore practical applications with the MinION.
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Antibiotic treatments make us more susceptible to negative emotions
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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Minute molecular movements might lead to more efficient biofuel cells
Leiden researchers have found minute movements in the laccase enzyme. This discovery could lead to the development of much more efficient biofuel cells. Publication in Biophysical Journal.
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ERC-subsidie om uit te zoeken hoe kinderen luchtweginfecties te lijf gaan
De crèche en het klaslokaal zijn misschien wel de meest gunstige plekken voor ziekteverwekkers. Toch is er relatief weinig bekend over hoe kinderen reageren op virussen en bacteriën en hoe het komt dat sommige kinderen veel beter beschermd zijn dan anderen. Simon Jochems, onderzoeker aan het Leids Universitair…
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Specialised immune cells have potential for new cancer immunotherapies
Researchers from Leiden University Medical Center (LUMC) and Netherlands Cancer Institute (NKI) have discovered how specialised immune cells can detect and remove cancers that are ‘invisible’ to the conventional defence mechanisms of the immune system. Their work has been published in Nature. The findings…
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Pharmacologist Rob van Wijk is highlighted author of the month
Pharmacologist Rob van Wijk is the Highlighted Trainee Author in the October 2019 issue of the Journal of Pharmacology and Experimental Therapeutics. In his research, Van Wijk aims for a new paradigm by combining experimental work and computational data analysis.
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IBL-research interview: Kirsten Leiss
Kirsten Leiss, at the IBL since 2001, is developing new ways of crop protection in order to decrease the use of pesticides: As a model she uses the thrip, a tiny insect which causes economic losses worldwide by silver- and growth damage and virus transmission to vegetables, fruits and flowers.
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New insights into the production of antibiotics by bacteria
Bacteria use antibiotics as a weapon and even produce more antibiotics if there are competing strains nearby. This is a fundamental insight that can help find new antibiotics. Leiden scientists Daniel Rozen and Gilles van Wezel published their research results in the authoritative Proceedings of the…
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'A garden on Mars' crowdfunding campaign starts today
Today, 13 students at Leiden University have started a crowdfunding campaign to collect money for research into the possibilities of growing crops on Mars. Their research will contribute to the knowledge of our galaxy. The project is in the context of the iGEM competition.
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Neanderthals coming out of the dirt
Extinct hominin DNA extracted from >40,000 years old sediment
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Leiden discovery evaluated by world-leading breeding companies
Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.
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Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
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CCLS Past Events
On this page you can find information about previous CCLS events.
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Medical Delta AI for Computational Life Sciences
The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?
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New light on innate plant immunity
Plants are able to resist a pathogen’s attack by a dual innate immune system. The relationship between the two pathways was not clear, but it turns out that they mutually potentiate each other, as assistant professor Pingtao Ding (Institute of Biology Leiden) and colleagues (The Sainsbury Laboratory,…
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Vici grants for 7 Leiden researchers
Seven Leiden researchers have been awarded a prestigious Vici grant by the Netherlands Organisation for Scientific Research (NWO).
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Antibiotic resistance: an economic problem universities could help to solve
Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.
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A unique defence: Bacteria lose cell wall in the presence of virus
Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…