1,285 search results for “ancient gene” in the Public website
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Priyanka Chopra
Science
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Guillermo Guerrero Egido
Science
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Merijn de Bakker
Science
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Manon de Visser
Science
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Remus Dame
Science
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Spatial patterns in landscape archaeology (publication)
In several Mediterranean regions archaeological sites have been mapped by fieldwalking surveys, producing large amounts of data. These legacy site-based survey data represent an important resource to study ancient settlement organization. Methodological procedures are necessary to cope with the limits…
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Snake genomes and toxin evolution
How did toxin genes evolve from harmless physiological genes?
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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The urban system in the North Western provinces
The first objective is to create a catalogue raisonée, i.e. a structured database that will store the main attributes of each town in a standardized format database, which will be freely accessible when completed; the second objective is to exploit theories and methods that can help us to understand…
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Amorites in the early Old Babylonian Period
This thesis explores several aspects of these Early Old Babylonian Amorites.
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White blood cells in transparent embryos
Leiden molecular cell biologists in the research group of Annemarie Meijer have discovered novel early macrophage-specific genes in zebrafish, including a signal transducer pivotal for the migration of macrophages in the innate immune response to bacterial infection. Their findings were published on…
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Migration and Mobility in the Early Roman Empire
Migration and Mobility in the Early Roman Empire by Luuk de Ligt and Laurens E. Tacoma (Eds.)
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LOCVS. Memory and Transience in the Representation of Place From Italic Domus to Artistic Environment
This study links up the concept of place with memory, with the idea of transience and the transition from life to death.
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Starchy foodways
Surveying Indigenous Peoples’ culinary practices prior to the advent of European invasions in the Greater Caribbean
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From Homo Economicus to Political Animal
Who is Economic Man? Every economic paradigm presupposes an anthropology, a theory of human nature. This project explores the anthropologies presupposed and produced by ancient Greek economic texts, and the specific knowledge forms that shape these anthropologies.
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Inventing anchors? The function of ‘Greek models’ within the process of innovation in Early Roman Drama
To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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Understanding the Endless Steppe
Otrar as a Case Study for a 6-10th century Transition Zone
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The Economy of Pompeii
This volume presents fourteen papers by Roman archaeologists and historians discussing approaches to the economic history of Pompeii, and the role of the Pompeian evidence in debates about the Roman economy.
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Key innate immune components controlling intracellular infection
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer
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PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
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The Unification of the Mediterranean World 400 BC - 400 AD
The Leiden Ancient History specialization concentrates on the study of the economies, societies and cultures of the large empires of the Graeco-Roman world, starting with the empires of Alexander the Great and his successors. The appearance of these empires led to the development of an interaction network…
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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The role of 14-3-3 proteins in ion homeostasis in the yeast Saccharomyces cerevisiae
We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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Mobility and exchange
Dynamics of material, social and ideological relationships in the pre-Columbian insular Caribbean
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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The Impact of Mobility and Migration in the Roman Empire
The Impact of Mobility and Migration in the Roman Empire assembles a series of papers on key themes in the study of Roman mobility and migration.
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From Universe of Visnu to Universe of Siva
Around the sixth and seventh centuries, South and Southeast Asia saw a great religious change: Saivism largely took over from Vaisnavism. We’re going to look at the way in which Saivism, the religion of the god Siva, presented itself with respect to Vaisnavism. In particular we’ll investigate the role…
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Ahmed Mahfouz: 'The mystery of brain diseases, unravelled cell by cell'
Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.
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Efficient targeting of the Trichoderma genome for industrial protein engineering
The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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ZF-CANCER - Developing high-throughput bioassays for human cancers in zebrafish
How can zebrafish research help to understand and fight human cancer?
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New antibiotics
Pathogenic bacteria are increasingly resistant to today’s antibiotics. Professor Gilles van Wezel seeks new forms of antibiotics in good bacteria that live in the soil.
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A Descriptive grammar of Sumerian
This grammar describes Sumerian, an ancient Near Eastern language which was spoken in what is now southern Iraq, on the basis of written sources dating from about 2500 to 2000 BC.
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ADAPTED
The ADAPTED (Alzheimer's Disease Apolipoprotein Pathology for Treatment Elucidation and Development) project is a major new initiative to investigate an area of Alzheimer's Disease (AD) research which has previously received little attention. The project aims to improve understanding of the function…
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Dynamic organization of bacterial chromatin by DNA bridging proteins
Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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The writing on the rocks: Thamidic and Arabia's linguistic past
This project aims to open up the pre-Islamic linguistic history of Arabia through the systematic study of the Thamudic inscriptions within a digital humanities framework.
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Thy Name is Deer. Animal Names in Semitic Onomastics and Name- Giving Traditions: Evidence from Akkadian, Northwest Semitic, and Arabic
Hekmat Dirbas defended his thesis on 14 February 2017
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T-DNA integration and DNA repair of DSBs in plants
Identification and characterization of components of DNA repair pathways and their role in Agrobacterium T-DNA integration and repair of CRISPR/Cas induced DSBs.
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Regulation of enzyme production in fungal cell factories
Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.
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Greater focus on pre-Islamic heritage
War and terrorism overshadow interest in the pre-Islamic heritage of the Arabic peninsula. The new Leiden Centre for the Study of Ancient Arabia aims to make the general public more aware of the ancient history of this region.
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Urbanism and municipal administration in Roman North Africa
This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.
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New open access, peer-reviewed journal: Arabian Epigraphic Notes
The Leiden Center for the Study of Ancient Arabia (LeiCenSAA) announces a new open access, peer-reviewed journal dedicated to the epigraphy of Arabia and its cultural and linguistic context: Arabian Epigraphic Notes
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Role of leukocytes in metastasis formation in a zebrafish
How do macrophages and neutrophils contribute to metastatic onset?
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.