564 search results for “sensitive vaderschap” in the Public website
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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The importance of friendships in reducing brain responses to stress in adolescents exposed to childhood adversity: a pre-registered systematic
Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.
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Graduate School of Science
Are you graduating at the Faculty of Science? Or are you supervising a PhD student? At the Graduate School of Science you find support at every phase of your PhD.
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Aggravating matters: accounting for baryons in cosmological analyses
Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.
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Semisynthetic glycopeptide antibiotics
Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.
- Mathematical Institute
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Enhancing Democracy and Citizens’ Trust in Governance: Adopting a Fair Treatment Approach in Indonesia’s Ombudsman Offices
How can the Indonesian National Ombudsman make the transition from autonomous to responsive justice in view of the day-to-day challenges it is faced with?
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Predicting the future: Predictive control for astronomical adaptive optics
The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.
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Effects of heavy fields on inflationary cosmology
Promotor: Prof.dr. A. Achucarro, Co-Promotor: J.W. van Holten
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Towards Optical Detection of a Single Electron
Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.
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Benchmarking Discrete Optimization Heuristics
This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.
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Sparsity-Based Algorithms for Inverse Problems
Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…
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Not so smooth after all: resolving dust and gas structures in protoplanetary disks
A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Die biblisch-hebräische Partikel נָא im Lichte der antiken Bibelübersetzungen. Unter besonderer Berücksichtigung ihrer vermuteten Höflichkeitsfunktion
My research addresses the function of the much-debated particle -nā in Biblical Hebrew, often translated with “please”, from the point of view of the most important ancient Bible translations (Greek, Syriac, Latin). It combines textual criticism, translation technique, discourse pragmatics, and the…
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Magnetic imaging of spin waves and magnetic phase transitions with nitrogen-vacancy centers in diamond
The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.
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Meaning and R/S (religion and spirituality) in medical healthcare
The project focuses on communication processes regarding spirituality and existential issues in the medical health care in the Netherlands
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UN celebrity diplomacy in China: activism, symbolism and national ambition online
In this article in International Affairs, Saskia Postema and Jan Melissen examine Chinese celebrities' UN-affiliated Weibo activism in the context of China's increasing engagement in the United Nations, which coincides with a shrinking domestic public sphere under Xi Jinping's leadership.
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Cost-utility of a guided Internet-based intervention in comparison with attention only for people with HIV and depressive symptoms: A randomized
We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.
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Matter into context: population- and community-level impacts of nanomaterials in freshwater ecosystems
The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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Above- and belowground interactions in Jacobaea vulgaris: zooming in and zooming out from a plant-soil feedback perspective
In this thesis, I focused on studying the above- and belowground interactions of J. vulgaris from a plant-soil feedback (hereafter, PSF) perspective. I investigated the temporal variation of negative PSF and examined the effects of root-associated bacteria on plant performance and aboveground herbiv…
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Innovative sample preparation and handling strategies for automated and high-throughput metabolomics
Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…
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Modelling the role of mycorrhizal associations in soil carbon cycling: insights from global analyses of mycorrhizal vegetation
In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.
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Low-temperature spectroscopic studies of single molecules in 3-D and on 2-D hosts
Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…
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Performance Requirement Prohibitions in International Investment Law
On Tuesday 17 October 2017 Alexandre Genest defended his PhD dissertation ‘Performance Requirement Prohibitions in International Investment Law’ as part of a double PhD programme at the Universities of Leiden and Ottawa. The Supervisors are Professors M.E. Koppenol-Laforce. F. Baetens (Universities…
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ELSA Lab Defence
Embedding ethical legal and societal aspects for responsible military AI.
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Development of Cost efficient Advanced DNA-based methods for specific Traceability issues and High Level On-site applications
Schneider
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Towards photo-CIDNP MAS NMR as a generally applicable enhancement method
Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Law and Governance in Muslim Societies
With regard to governance, policies and law, many Muslims and Muslim countries recognise the possibility that Islam has something important to say about the way society is to be ordered, governed, and regulated.
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Going global to local: achieving agri-food sustainability from a spatially explicit input-output analysis perspective
The global agri-food system plays a critical role in food security and environmental issues.
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Revealing the nature of new low-frequency radio source populations
It has now been well established that shocks and turbulent motions in the intra-cluster medium (ICM) generated through cluster mergers can produce large-scale synchrotron emission.
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Dear Future Me
Behavioral and neural mechanisms underlying self-concept development in relation to educational decision-making in adolescence
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Activity-Based Proteasome Profiling
Promotor: H.S. Overkleeft, Co-promotor: B.I. Florea
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Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration
On 11 June 2020, Sabine Witting defended her thesis 'Child Sexual Abuse in the Digital Era: Rethinking Legal Frameworks and Transnational Law Enforcement Collaboration'. The doctoral research was supervised by Prof. J.J. Sloth-Nielsen and Prof. S. van der Hof.
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Research
The main focus of our research programme is on adolescence, a key transitional period in human development. The programme puts emphasis on combined experimental behavioural and neural analysis of normative transitions and deviations in adolescent development.
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Brain networks and the initial stages of dementia
Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.
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Another Brick in the Wall: The role of the actinobacterial cell wall in antibiotic resistance, phylogeny and development
Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Microscale Analytical Tools
Enabling volume-restricted metabolomics using next-generation microscale analytical tools.
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Probing new physics in the laboratory and in space
The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.
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Journal of Quaternary Science
Scientists, including our faculty colleague Dr. Mike Field, studying an exceptionally well-preserved woolly rhinoceros have revealed details of what Britain's environment was like 42,000 years ago. The beast's remains were discovered in Staffordshire in 2002, buried alongside other preserved organisms…
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Neural correlates of vocal learning in songbirds and humans: cross-species fMRI studies into individual differences
Vocal learning is a trait shared by songbirds and humans. It is also a trait that is restricted by the brain rather than by a species' vocal apparatus. In this dissertation, functional MRI is employed in both species in order to explore potential common neural mechanisms underlying the ability to develop…
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Combined LC/MS-platform for analysis of all major stratum corneum lipids, and the profiling of skin substitutes
Ceramides (CERs), cholesterol, and free fatty acids (FFAs) are the main lipid classes in human stratum corneum (SC, outermost skin layer), but no studies report on the detailed analysis of these classes in a single platform.
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Academic Integrity
The integrity and reliability of academic research are of fundamental importance to the University. All parties, both within the University and outside, must be able to have confidence that our research is conducted in a scrupulous, fair, verifiable, impartial and independent manner. To make sure you…
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A History of Modern Political Thought in East Central Europe Volume II, part 1
A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…
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A History of Modern Political Thought in East Central Europe Volume II Part II
A History of Modern Political Thought in East Central Europe is a synthetic work, authored by an international team of researchers, covering twenty national cultures and 250 years. It goes beyond the conventional nation-centered narratives and presents a novel vision especially sensitive to the cross-cultural…
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Return to the Interactive Past. The Interplay of Video Games and Histories
A defining fixture of our contemporary world, video games offer a rich spectrum of engagements with the past.