Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

The insights leading to the present project firstly manifested themselves in 2008, when I worked with field recordings on the basis of relatively well-established notions in music composition studies, such as ‘musical material’ and écriture. With hindsight, I understand the outcomes of those first experiments…

This dissertation presents new cryptographic protocols, which can be divided into two families.

Ruobin Han defended her thesis on 21 March 2017

The civilizations of ancient China and Mesoamerica, although not historically related and obviously different in many specific aspects (such as language and writing), show many interesting commonalities and similar tendencies in their cultural manifestations.

Both Europe and Latin America face challenges globally and at home. Conflicts over land and resources have been resurgent in recent years.

Throughout the history of computer science, a major challenge has been how to assert that software is free of bugs and works as intended. Software bugs can lead to serious negative impacts on any software system. Throughout the main body of the thesis, we implemented a series of studies on exploring…

On the 4th of June, Menghui Shi successfully defended a doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Menghui Shi on this achievement!

This dissertation explores how domestic political power struggles in Greece and Turkey during the Cold War engaged with the ongoing conflict in Cyprus and aims to demonstrate how socialist parties in Greece and Turkey struggled with the concept of the “nation” in battling for power and political positioning…

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotores: Prof.dr. J. Zaanen & Prof.dr. K.E. Schalm

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.

How are contemporary art practices from Southeast Asia negotiating notions of art and tradition?

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

In our research protein translocation from Agrobacterium into yeast and plant cells is studied to obtain fundamental insights in the translocation process

Archaeometric analysis of glazed pottery assemblages from the Early Byzantine to the Early Modern periods in the Aegean.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

The marine shipping industry is one of the strongest emitters of nitrogen oxides (NOx), a pollutant detrimental to ecology and human health. Over the last 20 years, the pollution produced by power plants, the industry sector, and cars has been decreasing.

Band 69 | 2014

ASLU 28 Michalis Karambinis (2015)

This doctoral dissertation explores classical music performance from a curatorial perspective, reflecting upon and challenging the traditional configuration of performance environments.

On the 8th of March, Bushra Alkhamees successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Bushra on this achievement!

Heloisa’s doctoral research examines classical music performance from a curatorial perspective, reflecting upon and challenging the traditional configuration of performance environments.

Promotor: Ronald Cramer, Co-promotor: Serge Fehr

Although migration and integration have become important concepts today as a result of globalization, migration movements, integration, and multiculturalism have always been part of the history of Europe. Few people realize how many ethnic groups participated in migration within Europe or into Europe…

On 11 October, Amanda Pasma defended the thesis 'Re-entry support from prison-based and community-based professionals'. The doctoral research was supervised by Paul Nieuwbeerta, Hanneke Palmen and Esther van Ginneken.

Serge Rombouts is a physicist whose PhD thesis was about functional MRI (fMRI). This visualises activity in regions of the brain. The appealing images of glowing brain regions that emerge from the computer are the result of calculations. According to Rombouts, this isn’t proper artificial intelligence.…

Almost three years after receiving her honorary doctorate, Dr Graça Machel returned to Leiden University. Over the course of two days she spoke with students, researchers, and other interested persons, about human rights – particularly those of women and children – in a world in which these are continually…

This study relates the vicissitudes of the Amerindian peoples who lived or still inhabit the islands of Trinidad and Tobago, from the earliest occupants, ca. 8000 BC, until at present.

Eschatology played a central role in both politics and society throughout the early modern period. It inspired people to strive for social and political change, including sometimes by violent means, and prompted in return strong reactions against their religious activism.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

This book examines the critical role of information and knowledge in early modern Europe's global pursuits, exploring challenges in trusting distant information, the development of doubt in intercultural encounters, and the impact of misinformation.

This work represents the final results of several years of research within the Maya region. It deals with the relations between architecture and urbanism with landscape and astronomy.

Development and validation of instruments that can measure different aspects of emotional competence in children with normal and atypical development, and in different cultures

This paper addresses the gap that explores how agencies might allocate their personnel so as to maximise performance with the personnel they have.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

This book is the first comparative study of estimative intelligence and strategic surprise in a European context, complementing and testing insights from previous studies centred on the United States. It does extensive empirical analysis of open-source material and interviews in relation to three cases…

Between 1600 and 1800 countless manuals appeared on the subject: the improvised bass part on the harpsichord, pianoforte or organ. Musician and researcher Kathryn Cok unravels the secrets of the Dutch basso continuo accompaniment for modern-day musicians.

How is social cognition shaped by our knowledge of language and stories?

This paper contributes on an increasing body of work on radicalisation. It specifically focuses on what distinguishes individuals whose behavioural radicalisation includes involvement in terrorist violence from those whose behavioural radicalisation does not.

Mr. Jan van den Berg defended his thesis on 8 November 2018

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

Just published: United in incoherence – Private law concepts under pressure from European financial law (in Dutch), in: Tijdschift voor privaatrecht 2017-4