1,023 search results for “biomarkers discovery” in the Public website
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Four bold Faculty of Science researchers receive NWO XS grants
Four scientists from the Faculty of Science will receive a grant of up to 50,000 euros in the Open Competition Domain Science - XS from science financier NWO. This category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea.…
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Fundamental and translational medical biochemistry
Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…
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Leiden discovery of planetary births is worldwide news
In Germany, the United States and even in Vietnam: all over the world, the Leiden discovery of the birth of two planets was shared. Astronomer Sebastiaan Haffert and his team were able to record multiple planets in the making for the first time and published their findings in Nature Astronomy. A unique…
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Nobel Prize for physics: 'Clear solutions are the best discoveries'
What does Leiden physicist Wolfgang Löffler think about the award of the Nobel Prize for physics to Arthur Ashkin, Gérard Mourou and Donna Strickland?
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Discovery of a new Philippine monitor lizard (Varanus bitatawa)
'A spectacular new Philippine monitor lizard reveals a hidden biogeographic boundary and a novel flagship species for conservation' . CML-researcher Merlijn van Weerd has participated in a new article in Biology Letters about this discovery.
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European collaboration shines a light on enzyme discovery for industry
A European consortium has provided a disruptive technological breakthrough to allow the discovery and characterization of novel enzymes for industrial biotechnology. The technology will open the way to more efficient industrial processes such as in the biofuel, animal feed and paper and pulp industr…
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Rethinking drug discovery: Vidi grant for Laura Heitman
Laura Heitman has been awarded a VIDI grant for her innovative drug research. Heitman strives to optimize a drug’s binding kinetics at its target in order to ultimately fight diseases effectively. She even pleads for a paradigm shift in drug discovery.
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Drug discovery 3.0: more effective and humane
Discovering effective new drugs is a long, expensive and uncertain process. Laura Heitman wants to improve this by finding out more about how drugs bind to proteins that play a role in disease. She calls it ‘drug discovery 3.0’. Inaugural lecture on 9 December.
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Three discoveries for cleaner and cheaper fuel
How can rare and expensive materials be used more efficiently to produce cleaner and cheaper fuel? Under the guidance of Marc Koper, Professor of Catalysis and Surface Chemistry, international teams of scientists have published 3 articles in Nature Communications.
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Coen van Hasselt
Science
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New discoveries by the Leiden-Turin excavations in Saqqara
Archaeologists from the National Museum of Antiquities (Leiden), the Museo Egizio (Turin, Italy) and Leiden University have found the grave of Panehsy, the 'steward of the temple of (the god) Amun', in Saqqara.
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Erik Danen appointed as Professor of Cancer drug target discovery
As of April 1, 2018, Erik Danen has been appointed as Professor of Cancer drug target discovery at the Leiden Academic Centre for Drug Research (LACDR). His discipline is cell biology of cancer, in which he focuses on the mechanisms underlying metastasis and therapy resistance.
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The archaeological discovery at the Paardenmarkt in Alkmaar
In the summer of 2010, a special archaeological find resurfaced when plans to redevelop the Paardenmarkt, a parking lot in the historic city center of Alkmaar, began.
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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First discovery of high-energy neutrino source
For the first time, scientists have traced back a high-energy neutrino to its source in space. It was produced by a so-called blazar—a supermassive black hole. Researchers from neutrino detector IceCube report this in Science. ‘This is a milestone for neutrino science,’ says physicist Dorothea Samtleben…
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Freek Vonk gets his own show on Discovery Channel
Biologist Freek Vonk had already appeared in the Time Warp programme, where he was shown milking a snake for its venom, which he needed for his doctoral research. On Friday 18 September, he explained his fascination for snakes to Matthijs van Nieuwkerk in ‘De wereld draait door’, a Dutch news and entertainment…
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi
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ACTION
Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…
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NMR structural studies of protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Alumnus Robert Ietswaart: ‘Machine learning is revolutionising drug discovery’
Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…
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Neurodevelopmental risks in young children with an extra X or Y chromosome
This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.
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Will this discovery help us develop better catalysts?
Where exactly on the surface of a catalyst do the chemical reactions occur? Until now, it has always been a challenge to identify the exact locations of these ‘active sites’. In a new article in Nature, Leiden chemists helped their international colleagues reveal new insights into this issue. Their…
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PhD Research || Re-discovery of the Italian salterio
It was her original Salterio from 1725, built by Michele Barbi, which Franziska Fleischanderl could coincidentally acquire in 2014 that ignited her passion for this special string instrument. Before, she was focussed on contemporary music with modern Hackbrett.
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Astronomer Joe Callingham testifies against killer stars in new show on Discovery Channel
On Friday evening 17 September, Leiden astronomer Joe Callingham can be seen in a new series on Discovery channel. Killers of the Cosmos is about different deadly dangers lurking in the depths of space. Asteroids, cosmic debris, electromagnetic weapons… The show takes a film-noir approach to these threats,…
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Key publications
Key publications of the Predictive Pharmacology group.
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Discovery of a unique silver bowl from the Early Middle Ages
On an excavation site in Oegstgeest Leiden University archaeologists discovered a very rare silver bowl from the first half of the seventh century. The bowl is decorated with gold-plated representations of animals and plants and inlaid with semi-precious stones. The discovery suggests the existence…
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Anthe Janssen
Science
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Metabolic signatures in nutrition and health: short-term diet response, sexual dimorphism and hormone chronobiology
The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).
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Systems dermatology of immune-mediated dermatological diseases: cutaneous T-cell lymphoma
The complex pathophysiology of immuno-dermatological disorders is multifactorial, including environmental, skin microbiome, (epi)genetic and immune dysregulation conditions. This project primarily focuses on the orphan disease mycosis fungoides, a subtype of cutaneous T-cell lymphoma. The current pathophysiological…
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Strategy
The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.
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Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor
During the course of drug discovery translational steps are made.
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Flurry of new discoveries as incredible new image revealing 4.4 million galaxies is made public
Over a seven year period an international team of scientists has mapped more than a quarter of the northern sky using the Low Frequency Array (LOFAR), a pan-European radio telescope. From Leiden, Astronomer Timothy Shimwell and Huub Röttgering, among others, are involved. It reveals an astonishingly…
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Biophysical characterization of membrane protein-small molecule interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
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Sebastian Pomplun
Science
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Projects
An overview of Quantitative Pharmacology projects
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.
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GRIPonMASH
GRIPonMASH will address the unmet public health need of reducing disease burden and comorbidities associated with Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD).
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Data Analytics and Management
Our group is part of the Metabolomics and Analytics Centre where we accompany the data from its acquisition all the way to the publication of identified associations and biomarkers for a range of human diseases. The generated data of the metabolic measurements are assessed using an in-house quality…
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Improving immunotherapy for melanoma: models, biomarkers and regulatory T cells
PhD defence
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Biomarkers and Prognosis in Cardiac Surgery in the ICU
PhD defence
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Improving Diagnostic, Prognostic and Predictive Biomarkers in Colorectal Cancer
PhD defence
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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Anxiety and cognitive performance: better insights and new treatments
How does stress influence cognitive performance? What is the role of selective attention to threatening information in this effect? Could we prevent stress-induced decline of cognitive performance with pharmacological interventions? Could we use resting state theta/beta ratio as a biomarker for cognitive…
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Health Data Science
Health research, medical practice and consequently the whole population is increasingly affected by digitization, data science and AI.
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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UM Cure 2020: New therapies for uveal melanoma
Can we bring novel treatment options to the clinic for UM patients with liver metastases?
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Data science
The majority of scientists, from archaeologists through to zoologists, collect enormous volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics and computer science, we can develop algorithms for analyzing…