550 search results for “binding studieadvies bsa” in the Public website
-
Biotic ligand models
Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)
-
Programme structure
Throughout your 3-year Security Studies programme you explore the effects of events (such as war or natural disaster), understand them via relevant academic perspectives, and actively design strategies and solutions to resulting security challenges.
-
Programme structure
Throughout your 3-year Science for Sustainable Societies programme, you will learn about the importance of analysing complex sustainability challenges using an interdisciplinary perspective.
-
Paradigm-shifting theory highlights the importance of substrate flexibility in enzymatic reactions
Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…
-
Laura Heitman nominated for Prix Galien
Laura Heitman of the Leiden Academic Center for Drug Research (LACDR) has been nominated for the Prix Galien Research Award. This important pharmaceutical prize honors young, prominent researchers whose scientific research is of great importance for fundamental or clinical drug research.
-
Evolutionary diversification of Nepenthes (Nepenthaceae)
Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes
-
About us
The Sport Data Center (SDC) consists of the data science disciplines of Leiden University and Technical University Delft, combined with the sport science branches of the Amsterdam Institute for Sport Science and the Sport Engineering Institute of the Technical University of Delft.
-
Metastability for low-temperature Kawasaki dynamics with two types of particles
Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi
-
Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.
-
Mechanism-based inhibitors and probes for neuraminidases
Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.
-
Dynamics of a β-lactamase
BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.
-
Rethinking Political Obligation. Moral Principles, Communal Ties, Citizenship
Why obey the state? Dorota Mokrosińska presents a fresh analysis of the most influential theories of political obligation and develops a novel approach to this foundational problem of political philosophy, an intriguing combination of the elements of natural duty and associative theories.
-
Elective Monarchy in Transylvania and Poland-Lithuania, 1569-1587
This book is an examination of why and how the elective principle, already established in Transylvanian and Polish political culture in the late medieval period, was transformed in the early elections of the 1570s.
-
Chemistry & Chemical Biology approaches toward novel cyclic peptide antibiotics
Can cyclic peptides provide a new generation of antibiotics?
-
Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
-
Dirk Bouwmeester Lab - Quantum Optics and Quantum Information
The research program of the QO group has three leading themes: Optical Physics, Quantum Optics, and Photon-Matter Interactions. We work mostly at the boundaries between these themes with entanglement as a bridging and binding agent.
-
Classical and paramagnetic NMR spectroscopy applied to different protein systems
Promotor: Prof.dr. M. Ubbink
-
Synthetic peptides as tools in chemical immunology
This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.
-
The role of trust in economic decisions
What are the essential determinants of (dis)trust? And, what are the effects of being (dis)trusted?
-
Novel receptor concepts
.
-
Medicinal Chemistry
The mission in this division, headed by Laura Heitman, is to design and synthesize novel and better ligands for drug targets. Drug discovery is a lengthy but inspiring adventure. It is often an interplay between academic institutes and pharmaceutical industry, in which scientists at university develop…
-
Annual Report 2023 published
In its new Annual Report 2023, Leiden University reviews its research and teaching, as well as its ICT, staffing, finances, real estate, impact and knowledge transfer.
-
Regional Approach to Financial Statecraft: Japan and India in the Face of Rising China
On Thursday 10 November, the GTGC organized a research seminar. During this seminar Saori Katada presented her paper on Regional Approach to Financial Statecraft: Japan and India in the Face of Rising China.
-
Light-activatable metallodrugs and metal-functionalized liposomes
Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…
-
Publications
Relevant publications of the CIGR participants.
-
Matching
As part of your application procedure for the bachelor’s programme English Language and Culture, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also…
-
Matching
As part of your application procedure for the bachelor’s programme Arts, Media and Society, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer…
-
Matching
As part of your application procedure for the bachelor’s programme Linguistics, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…
-
Matching
As part of your application procedure for the bachelor’s programme Philosophy: Global and Comparative Perspectives, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations.…
-
Keywords
A list with keywords and all the information you need in your first year. Click on the links and read more about the subjects you want to learn more about.
-
Chemical Probe Facility
The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…
-
Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
-
Transferring
Transferring to the Bachelor's programme in Psychology at Leiden University
-
Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET
PhD defence
-
Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
- Cold War
-
Matching
As part of your application procedure for the bachelor’s programme Archaeology, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…
-
Matching
As part of your application procedure for the bachelor’s programme Archaeology, you are asked to complete an Online Matching module. By watching a number of video lectures and answering questions about them, you will discover whether the programme fits your expectations. You will also answer a number…
-
NO-ESKAPE New Strategies for Overcoming the ESKAPE Pathogens
Natural product inspired antibiotics to address resistance
-
Functions of P38 and ERK kinases in zebrafish early development
Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar
-
The activation mechanisms of G protein-coupled receptors: the case of the adenosine A2B and HCA2/3 receptors
Promotor: A.P. IJzerman
-
Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
-
Cross-border Claims to Cultural Objects
On 11 November 2021, Evelien Campfens defended the thesis 'Cross-border Claims to Cultural Objects'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. W.J. Veraart (VU Amsterdam).
-
Freedom of additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
-
Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
-
The Derivational Timing of Ellipsis
This volume explores the nature of ellipsis, the core phenomenon that results in various types of omission in sentences.
-
Design, synthesis and application of paramagnetic probes for protein structure studies
The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.
-
Optoplasmonic detection of single particles and molecules in motion
Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.
-
Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
-
3D Image to Characterize and Optimize antibody-mediated antitumor immunity
Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…