Supramolecular polymers are class of materials that are formed by non-covalent interactions such as hydrogen bonding, π-π interactions, electrostatic interactions and the hydrophobic effect.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Pioneering in the archaeology of Somaliland, hosting international TV and radio shows, and producing a very successful MOOC: Dr Sada Mire already has a formidable track record.

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

The present study aims to establish and develop guidelines for effective use of the classical guitar’s scoring potential.

Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

Caribbean archaeological heritage is threatened by natural impacts but also increasingly by economic developments, often resulting from the tourist industry. The continuous construction of specific projects for tourists, accompanied by illegal practices such as looting and sand mining, have major impacts…

In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…

Local Knowledge Syndrome and Donor-Promoted Public Sector Reforms in Developing Countries. Effective development often fails because relief organizations don't study the local knowlegde and problems, says Moosa Elayah. A Local Bank of Knowledge can be the answer.

The aim of this research was to develop an effective, generative, and practical approach to enhance students’ structure-property reasoning (SPR).

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Tuberculosis (TB) is associated with 1.5 million deaths annually. There is a need exists to optimize both current as well as novel antibiotic combination treatment strategies to improve the effectiveness and safety of treatments against TB.

Bernini and Pallavicino, the artist and the Jesuit cardinal, are closely related figures at the papal courts of Urban VIII and Alexander VII, at which Bernini was the principal artist. The analysis of Pallavicino's writings offers a new perspective on Bernini's art and artistry and allow us to understand…

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Political Scientist Gisela Hirschmann (Leiden University) asks how international organisations can be compelled to comply with respect human rights. She finds that this is done through ‘pluralist accountability’: external third parties such as courts, NGOs, or regional organisations holding international…

In this research we have studied how teaching graphing formulas by hand (i.e. sketching a graph of a formula) could promote grade 11- and 12-students’ symbol sense.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

The transition period in which men become fathers might provide an important window of opportunity for parenting interventions that may produce long-term positive effects on paternal care and, consequently, child development. Existing prenatal programs traditionally focus on maternal and infant health…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

The territories that would make up what is today the Republic of Zambia officially became British in 1891. However, this did not equate to an on-the-ground presence of colonial authority capable of affecting the destiny and daily lives of people.

Haunted Europe offers a comprehensive account of the British and Irish fascination with a Gothic vision of continental Europe, tracing its effect on British intellectual life from the birth of the Gothic novel, to the eve of Brexit, and the symbolic recalibration of the UK’s relationship to mainland…

Almost fifty scientists and twenty companies will be working on developing new antibiotics and alternatives for antibiotics use. NWO and the Ministry of Health, Wellbeing and Sport will together invest close to seven million euros in this research. Scientists from Leiden University and LUMC will be…

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

Daniel Soliman defended his thesis on 15 September 2016.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.

How does governing work today, and how does society handle pressing challenges in ways that are democratic, effective, fair, peaceful, and sustainable?

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

Introduction to Medieval Europe 300–1500 provides a comprehensive survey of this complex and varied formative period of European history, covering themes as diverse as barbarian migrations, the impact of Christianisation, the formation of nations and states, the emergence of an expansionist commercial…

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

Professor of Archaeometry Patrick Degryse analyses archaeological finds using techniques from chemistry, physics and biology. He will give his inaugural lecture on 19 February. He reflects on three interesting propositions from his lecture.

'The Routledge Handbook of Civil and Uncivil Society in Southeast Asia' explores the nature and implications of civil society across the region, engaging systematically with both theoretical approaches and empirical nuance for a systematic, comparative, and informative approach.

In a longitudinal study, Eichengreen and colleagues explored how the certain aspects of emotional intelligence impact the development of adolescents’ mental health, thus identifying potential warning signs and targets for intervention programs. Despite a higher risk for mental health issues and lesser…

Nanoparticles that transport medicines to a specific part of the human body are usually broken down in the liver prematurely. Jeroen Bussmann from Leiden University has discovered a new method to prevent this from happening. Publication in ACS Nano.

Neurologist Professor Michel Ferrari has been awarded the Spinoza prize. 'In biomedical research you can only make breakthroughs at the borders between sciences,' according to Spinoza, doctor and scientist. 'This prize is proof that co-operation works.' Together with clinical and fundamental researchers…

The General Data Protection Regulation (GDPR) came into force in 2018. It was intended to protect the rights and freedoms of individual citizens from the risks of personal data processing. Meanwhile, the phenomenon known as big data has continued to advance at a fast pace. PhD defence on 12 Septembe…

Having a bachelor's, a master's and a PhD in Chemistry, Elena Sánchez López shifted to a more biological field of research for her postdoc. She completed all her studies at the University of Alcala, in Spain, before applying for a LEaDing fellowship at Leiden University, a Marie Sklodowska-Curie Cofund…

Researchers at Leiden University led by Mario van der Stelt (Leiden Institute for Chemistry) have set ‘gold standards’ for developing new painkillers based on the medicinal effects of cannabis. Publication in Nature Communications.

PhD defence

The law and Artificial Intelligence (AI) applications need to be better aligned to ensure our personal data and privacy are protected. PhD candidate Andreas Häuselmann can see opportunities with AI, but dangers if this does not happen.

Conference

Lecture

‘Collaboration is increasingly important,’ Rector Magnificus Carel Stolker said at the 445th Dies Natalis of Leiden University on 7 February. But, as he heard from a number of Leiden researchers, this is contingent upon a firm disciplinary basis. A novelty of this year’s celebration was a joint dies…