141 search results for “x-ray” in the Public website
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Buddhist and Hindu Metal Images of Indonesia: Evidence for shared artistic and religious networks across Asia (c.6th-10th century)
Mathilde Mechling defended her thesis on 28 january 2020.
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Understanding the physical properties that affect the lipid organization in the skin barrier
It is the aim of this project to better understand how the physical properties of lipids influences the structure and overall barrier function of the skin.
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Network flow algorithms for discrete tomography
Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele
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Reconstruction Methods for Combined HAADF-STEM and EDS Tomography
The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.
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Cathodic corrosion
Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.
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The structure of the dusty cores of active galactic nuclei
Promotor: W. Jaffe, Co-promotor: K. Meisenheimer
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Alexey Boiarskyi Group - Particle and Astroparticle Physics
My work is motivated by the necessity to extend Standard Model of Particle Physics in order to explain three observed phenomena that this great theory fails to accommodate
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Clues from stellar catastrophes
Promotores: S.F. Portegies Zwart, E. M. Rossi
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Expertise
The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.
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Cosmic particle acceleration by shocks and turbulence in merging galaxy clusters
In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).
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Exploring the interactions of M dwarf winds and cosmic rays
This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.
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In vitro model systems for studying the impact of organic chemicals on the skin barrier lipids
This paper describes two synthetic lipid models designed to replace human stratum corneum (SC) in studies of the impact of volatile organic chemicals on the molecular organization of the skin barrier lipids.
- Cosmology
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On the optimization of imaging pipelines
In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…
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Software developments in automated structure solution and crystallographic studies of the Sso10a2 and human C1 inhibitor protein
Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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Nanoparticulate Impurities in Pharmaceutical-Grade Sugars and their Interference with Light Scattering-Based Analysis of Protein Formulations
PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.
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Unveiling the invisible conformational landscape of cytochrome P450
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Microscopy and Spectroscopy on Model Catalysts in Gas Environments
In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.
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Van Marum Colloquia
The "Van Marum Colloquia" are a collaborative lecture series between the LION and LIC institutes, focusing on fundamental and applied surface science.
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Cum laude on understanding catalysts under extreme conditions
Physical chemist Rik Mom developed a revolutionary way to investigate catalysts in action in detail. For this work he received the distinction cum laude during his PhD defence on 29 June.
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A new step in the search for the origin of dark matter
A signal that is present both in the centre of our Milky Way and in distant places in the universe could reveal the origin of dark matter. This is what Leiden physicist Alexey Boyarsky concludes in an article in Physical Review Letters.
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Steffen Brünle
Science
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Charlemagne's Workshops
An Investigation into the role of copper-alloy craft production in the early medieval economy of northwest Europe.
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Deep imaging
A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.
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Boudewijn Lelieveldt: 'AI can help, but not replace, doctors and other healthcare providers'
‘I would never want to be treated by a computer,’ says Boudewijn Lelieveldt, Head of Radiology at the Laboratory for Clinical and Experimental Image Processing and Medical Delta professor in the Bioinformatics group at Delft University of Technology. No matter how intelligent a system, we have to continue…
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Research
Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:
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Aarts Lab - Magnetic and Superconducting Materials
In the Aarts lab we combine or structure materials, mostly in thin film form, in such a way that the hybrid has different and novel properties or functionalities.
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Programme
The symposium is open to all registered participants and consists of two sessions and a Poster Session.
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Ancient Charm
The aim of ANCIENT CHARM was to develop neutron-imaging techniques and the associated equipment, and help establish neutron imaging as a mainstream archaeological analytical technique. In particular, one of the goals was a new imaging technique which called neutron resonant capture imaging combined…
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Pioneering techniques to probe the solid-liquid interface using the soft X-rays of the VerSoX beamline at Diamond Light Source
Lecture
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Research lines
Current research at the Skin Barrier and Vaccination group.
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Digitally leafing through invisible books
Researchers from Leiden and Delft have found a way to look inside early-modern bookbindings. An x-ray technique has allowed them to search for remains of medieval manuscripts hidden inside the bindings. After the Middle Ages many manuscripts were recycled, their pages pasted inside bookbindings to provide…
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Towards nano-MRI
By detecting the tiny forces between a micrometer sized magnet and the spins of hydrogen nuclei, we can do MRI with a volume resolution that is approximately 12 orders of magnitude better than a conventional MRI.
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Computer Science at Leiden University
Leiden Institute of Advanced Computer Science (LIACS)
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Metals in Catalysis, Biomimetics & Inorganic Materials
Coordination chemistry is the chemistry of metal atoms
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Habitable planets around pulsars theoretically possible
It is theoretically possible that habitable planets exist around pulsars, rotating neutron stars. Such planets must have an enormous atmosphere that convert the deadly X-rays and high energy particles of the pulsar into heat. That is stated in a scientific paper by astronomers Alessandro Patruno and…
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Latest hardware for computer research on medical imaging
The LIACS Media Lab has received a research grant from the worldwide leading graphics hardware company NVIDIA. The grant exists of newly developed hardware utilizing thousands of processors. LIACS researchers will use it to investigate deep learning in understanding imagery from sources such as MRI…
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First step in converting solar energy using ‘artificial leaf’
Two things are needed to produce fuel from sunlight: an antenna that harvests light, and a light-driven catalyst. The most efficient antennae contain bacteria. An international team headed by Huub de Groot imitated them and discovered how they function.
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Subsidies for high-grade research facilities
Three projects with Leiden researchers are to receive a subsidy from NWO for the construction or renovation of large-scale research facilities. They will be working on electron microscopy, an X-omics initiative and an X-ray telescope. The projects are part of the National Roadmap for Large-Scale Scientific…
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Leiden University strengthens its focus on Chemical Biology and Medicinal Chemistry with seven new group leaders
Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…
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Surface and Interface Science
The nanoscale structure of a catalyst under reaction conditions determines its activity, selectivity, and stability. For the production of sustainable energy and materials, new catalysts are needed. By understanding the structure-activity relationships of catalysts under reaction conditions, insight…
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Research
Research at the Macromolecular Biochemistry group is comprised of the following research themes:
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Alumni
Former PhD, Bachelor and Master students of the Van Exter Lab
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Neutrino linked to black hole that devours star
For only the second time ever, astronomers have linked a neutrino to an object outside our Milky Way. These observations were made using telescopes both on Earth and in space. The researchers, including Leiden astronomer Sjoert van Velzen, were able to trace the neutrino to a black hole that is devouring…
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Newton-telescope finds missing intergalactic material
Astronomers from, among others, SRON and Leiden Observatory have discovered long-sought intergalactic gas with ESA’s space telescope XMM-Newton. This gas is one of the pieces of the puzzle to map the total amount of ‘normal’ matter in the universe. The research will be published in Nature on 21 June…
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Launch International Journal of Multimedia Information Retrieval
Leiden University and Springer launched International Journal of Multimedia Information Retrieval.
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Renewable Energy
The transition to new and renewable energy sources should be completed by 2050. Researchers in various disciplines at Leiden University are conducting unique research that will help us make this transition and reduce CO2 emissions.