1,797 search results for “thijs werkt e2 80 99s discovery” in the Public website
-
LED3 Lecture: Proteomics in Drug Discovery
Lecture
-
Discovery of selective diacylglycerol lipase β inhibitors
Diacylglycerol lipases (DAGLα and DAGLβ) are responsible for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG) in the brain and peripheral tissues. Selective DAGLβ inhibitors have been proposed as a potential treatment for inflammatory diseases with reduced potential for central…
-
Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
-
Discovery and characterization of new glucosylated metabolites: pathophysiological consequences
Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.
-
The Role of Target Binding Kinetics in Drug Discovery
Source: ChemMedChem (2015)
-
Discovery of BUB1 kinase inhibitors for the treatment of cancer
The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.
-
Antibiotic Discovery: From mechanistic studies to target ID
The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.
-
Scientific computing for Drug Discovery in Python and/or R
Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.
-
Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
-
Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
-
Activity-based protein profiling for drug discovery
Activity-based protein profiling (ABPP, also termed chemical proteomics), is one of the pillars of chemical biology, and at LED3 we have taken it to the next level. ABPP allows the assessment of protein function in live cells and tissues, which means that the activity of a complete protein family can…
-
Discovery of novel inhibitors to investigate diacylglycerol lipases and α/β hydrolase domain 16A
Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt
-
Harnessing zebrafish xenograft models for ocular melanoma treatment discovery
The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…
-
Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
-
Knowledge Discovery and Data Mining from patient experience repositories
This project develops a scientific method to extract clinically relevant new information from patient forum websites that discuss patient experiences concerning e.g. medication, nutrition, co-morbidities, genetic factors etc.
-
Causal Discovery from High-Dimensional Data in the Large-Sample Limit
Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets
-
Evani Lachmansingh
Science
-
Discovery of novel Antibiotics from Actinomycetes by Integrated Metabolomics & Genomics Approaches
Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi
-
Systems microscopy-based drug target discovery in pathogen-meidated inflammatory respons signalling
Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…
-
Mortality and HyperImage: Visual analytics techniques for biomarker discovery in massive 3D-omics datasets
Over the past decade, several novel types of spatially resolved
-
resources for Iberian empires: ecology and globalization in the age of discovery
An interdisciplinary and innovative research group combining History, underwater archaeology, GIS and wood provenancing methods.
-
Thijs Porck wins LUS Teaching Prize 2019
Lecturer in Old and Middle English Thijs Porck was awarded the annual Leiden University Student Platform (LUS) Teaching Prize at the opening of the academic year. The jury praised his endless supply of innovative teaching ideas.
-
Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken
-
data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
-
Knowledge discovery from patient forums: gaining novel medical insights from patient experiences
Patients share valuable advice and experiences with their peers in online patient discussion groups.
-
Image-based phenotypic screening for breast cancer metastasis drug target discovery
The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.
-
Discovery and exploitation of the transcriptional regulatory system of pectinases in Aspergillus niger
Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.
-
Discovery and development of inhibitors selective for human constitutive proteasome and immunoproteasome active sites
This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.
-
of data: connecting large datasets with machine learning in a drug discovery envirionment
This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…
-
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice, Nat. Chem. Biol. 2020
N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.
-
Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
-
PROTEOMINING: a novel proteomics-based pipeline for drug and enzyme discovery in filamentous actinomycetes
Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?
-
Hans Aerts
Science
-
Mendelssohn and Johann Georg Sulzer in the Berlin salon music of the 1750–80’s
My research focuses on theories of the sublime by the Berlin Enlightenment philosophers Moses Mendelssohn (1729–86) and Johann Georg Sulzer (1720–79).
-
The Discovery of El Greco: The Nationalization of Culture Versus the Rise of Modern Art (1860-1915)
The Discovery of El Greco: The Nationalization of Culture Versus the Rise of Modern Art (1860-1915)
-
Thijs Porck participates in the SELIM conference in Granada, Spain
From 17 to 19 September, the University of Granada organized the 27th International Conference of the Spanish Society for Medieval English Language and Literature (SELIM).
-
Leiden University hosts conference uniting 80 world-class scientists
A team of researchers from Leiden Institute of Advanced Computer Science (LIACS) recently hosted a big international conference (EMO 2023). At the conference, computer scientists discussed algorithms that are important in areas such as drug discovery, industrial production planning, and sustainable…
-
Afternoon of Discoveries for children
As a prelude to the Night of Discoveries, an Afternoon of Discoveries will be held in Leiden on 21 September for children from the age of eight. Researchers will tell exciting tales and the children will get to do experiments.
-
In pictures: the Night of Discoveries
Over 4,000 visitors came to the seventh edition of the Night of Discoveries, a festival of knowledge and culture, on Saturday 21 September. On this the last summer evening of the year, the festival-goers were treated to over 170 acts on the theme of light and dark, making it a vibrant, busy, educational…
-
Molecular Physiology
Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…
-
Five tips for The Night of Discoveries
Discover budding creators, artists and researchers at the Night of Discoveries art and knowledge festival. And many researchers from Leiden University are taking part.
-
Mario van der Stelt
Science
-
Gerard van Westen
Science
-
Madeline Kavanagh
Science
-
Oncode Accelerator
Providing each cancer patient with the right treatment remains a challenge. Oncode Accelerator aims to change this by innovating the way we develop cancer treatments, thus ensuring the patient is at the heart of the process. Leiden University, the LUMC and other partners will implement this new way…
-
Astonishing explorations at the Night of Discoveries
It was the Night of Discoveries on Saturday 16 September: a summer encounter between art and science. Leiden researchers from various disciplines inspired the public with their quest to understand our world.
-
Microbes buried at the bottom of the sea start flourishing after 80.000 years
In otherwise energetic desserts at the bottom of the sea, researchers have found oases where microbes can harvest energy. Remarkably, the microbes first have to be buried under starving conditions for 80,000 years. An international group of researchers, amongst them José Mogollón from the Insitute of…
-
Webinar numerus fixus Politicologie/Internationale Politiek
Study information
-
HZ Kenniscentrum Zeeuwse Samenleving
HZ Kenniscentrum Zeeuwse Samenleving doet op vraag van regionale overheden en maatschappelijke organisaties onderzoek naar actuele en maatschappelijke thema’s in de provincie Zeeland. De uitkomsten van onderzoeken en analyses worden gebruikt voor kennisopbouw en als basis voor beleidsopbouw en -ontwikkeling.…
-
Webinar numerus fixus Politicologie/Internationale Politiek
Study information