533 search results for “since role” in the Public website
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Civil Society against Corruption in Ukraine: Political Roles, Advocacy Strategies and Impact
This project aims to provide evidence-based knowledge on the conditions for successful anti-corruption activism in Ukraine.
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The role of lipids in the barrier function of the skin
The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…
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A family affair? Exploratory insights into the role of family members of those who joined jihadist groups
Since 2012, thousands of individuals have traveled from Western countries to join jihadist groups in Syria and Iraq. While much has been written about these individuals, only sparse attention has been paid to the social environment of these jihadist travelers and, more specific, the role of family members…
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A study on PsbS and its role as a pH sensor
Solar energy harnessed by plants and algae has great potential to be converted into biofuels for future generations.
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Understanding protein complex formation: The role of charge distribution in the encounter complex
Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.
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The Social Ties that Bind: Unraveling the Role of Trust in International Intelligence Cooperation
Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.
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The role of research in university teaching: a comparison of Chinese and Dutch teachers
This dissertation reports on the beliefs and perceptions of Chinese and Dutch university teachers regarding the role of research in university teaching and how these beliefs and perceptions can be explained by their cultural, institutional and individual background characteristics
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Developing drawing skill: Exploring the role of parental support and cultural learning
Drawing is one of the most unique human behaviours. Like language, drawing is a mode of communication and a cognitive tool that from an early age allows us to interact with others. Is the early development of drawing skill influenced by the social environment? If so, how?
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Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
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‘Non-Istanbulites’ of Istanbul: Quest for a place in Istanbul in the Turkish novel since the 1960s
This research focuses on a historical/social analysis of a selected corpus of novels from modern Turkish literature which have the common theme of migration from Anatolian towns and villages to Istanbul, and the immigrants’ struggle in this city against various exclusion mechanisms.
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Central role of Claudin-1 in lesional but not in non-lesional atopic dermatitis
Source: Journal of Investigative Dermatology, Volume 134, pp. S44-S44 (2014) ISBN: 0022-202X
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Cutaneous barrier dysfunction in atopic eczema: the role of stratum corneum lipids
Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 148-148 (2015) ISBN: 0142-5463
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Role of near-surface environment in tuning electrochemical CO2 reduction reaction and H2 evolution reaction
This thesis has shed light on some of the ways in which the local electrolyte composition can differ from the bulk and how these changes in the local reaction environment can determine the activity and/or selectivity of two important electrocatalytic reactions, namely, electrochemical CO2 reduction…
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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Uncertainty and Employees’ Daily Innovative Work Behavior: The Moderating Role of Ambidextrous Leadership
Bernard Bernards examines constraints on innovation by focusing on cognitive uncertainty as a personal state that may affect innovative work behavior.
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The role of AGC3 kinases and calmodulins in plant growth responses to abiotic signals
Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa
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The role of expectancies and avoidance learning in the maintenance of somatic symptoms
Somatic symptoms, such as pain, itch, and fatigue have been shown to have a bidirectional relationship with mental symptoms. Although acute somatic symptoms serve some adaptive properties, chronic symptoms can instead lead to interference in daily activities and lower quality of life.
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Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.
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The mystical kiss of the mouth. The role of images and imagery in medieval spirituality (1100-1500)
How can the importance of the image in late medieval spirituality be understood in the context of the love mysticism inspired by the imagery of the Song of Songs?
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Congruence between voters and parties: The role of party‐level issue salience
The level of congruence between parties and their voters can vary greatly from one policy issue to another, which raises questions regarding the effectiveness of political representation. We seek to explain variation in party–voter congruence across issues and parties.
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The role of zebrafish larvae for studying anxiety-like behaviour
The main aim of my Ph.D. thesis is to further explore the value of using early developing zebrafish larvae (up to 5 dpf) as a model to study anxiety-like behaviour and their pharmacological modulation with drugs.
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Democratic Secrecy: A Philosophical Study of the Role of Secrecy in Democratic Governance
The starting hypothesis of the project is that secrecy is not always inimical to democratic governance as conventional wisdom has it.
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Analogy, Technical Reason, and Living Beings: The Role of Analogy in Representing Kant's Concept of Naturzweck
This dissertation concerns the role of analogy in Kant’s “Critique of the Teleological Power of Judgment”, especially the role of analogy for the formation of the concept of a natural end (Naturzweck). A ‘natural end’ is a ‘regulative concept’ of the reflective power of judgment, that is, a heuristic…
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Role of non-homologous end-joining in T-DNA integration in Arabidopsis thaliana
Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater
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The role of ceramide chain length distribution on the barrier properties of the skin lipid membranes
The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects
On 20 October 2021 Michael Ramsden defended the thesis 'The Role of the United Nations General Assembly in Advancing Accountability for Atrocity Crimes: Legal Powers and Effects'. The doctoral research was supervised by Prof. N.M. Blokker.
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More than a digital system: how AI is changing the role of bureaucrats in different organizational contexts
In this paper, Sarah Giest and Bram Klievink highlight the effects of AI implementation on public sector innovation. This is explored by asking how AI-driven technologies in public decision-making in different organizational contexts impacts innovation in the role definition of bureaucrats.
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Lipid to protein ratio plays an important role in the skin barrier function of atopic eczema patients
The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Dead or Alive? The role of personal characteristics and immediate situational factors in the outcome of serious violence
Why do certain incidents of serious violence end lethally whereas others do not? What role do personal characteristics of offenders and victims play and how do immediate situational factors influence outcomes?
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organizational learning orientations in the wake of a crisis and the role of public service motivation
This study explores public leaders’ organizational learning orientation in the wake of a crisis. More precisely, we study the association between public leaders’ public service motivation and their learning orientation (instrumental versus political).
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Why do citizens (not) support democratic innovations? The role of instrumental motivations in support for participatory budgeting
In recent years, the question why citizens (do not) support democratic innovations has attracted increasing academic attention. In this research note, Van Der Does & Kantorowicz for the first time empirically verify what drives citizens’ instrumental considerations in their evaluation of a DI.
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Modelling the role of mycorrhizal associations in soil carbon cycling: insights from global analyses of mycorrhizal vegetation
In this PhD study, I aim to deepen our understanding of the influence of major mycorrhizal types, namely arbuscular mycorrhizae (AM) and ectomycorrhizae (EM), on the global soil carbon cycle and their potential distribution changes under future environmental shifts.
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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The Scandal of Cal: A Conversation about the Role of Academic Institutions in Historical Exploitation
Lecture, Global Questions Seminar
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law
On 23 juni 2019, Zygimantas Juska defended his thesis 'The Role of Collective Redress Actions to Achieve Full Compensation for Violations of European Union Competition Law'. The doctoral research was supervised by Prof. dr. T.R Ottervanger.
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Robert Verpoorte
Science
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Searching for the concrete subject: On the epistemic role of lived-experience in Paul Natorp's critical epistemology
The following dissertation reconstructs Paul Natorp's philosophical psychology. It argues that psychology's main object is the lived experience of concrete subjects, understood as a transcendental structure of logical-reflexive conditions for the recognition, appropriation, and evaluation of objective…
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Getting to the Core of Crimmigration. Assessing the Role of Discretion in Managing Intra-Schengen Cross-Border Mobility
To what extent are there differences between countries in and outside the European Union and the Schengen area in the level of crimmigration, the merger between migration control and crime control, and to what extent can these differences be explained by the way in which state and non-state actors in…
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The role of hearing signers in the development of channel specific structures in sign languages of deaf communities
In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.
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The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival
On 19 December 2019, Reza Eftekhar defended his thesis 'The Role of the Domestic Law of the Host State in Determining the ratione materiae Jurisdiction of Investment Treaty Tribunals: The Partial Revival of the Localisation Theory'. The doctoral research was supervised by Prof. E. de Brabandere.
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Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International
On 7 November 2018, Catherine Harwood defended her thesis 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. The doctoral research was supervised by Prof. dr. L.J. Van den Herik and Prof.…
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Politics, pandemics, and support: the role of political actors in Dutch state aid during COVID-19
How do governments distribute resources across economic sectors during a crisis? And why do some sectors receive more than others? The recent COVID-19 pandemic has highlighted the urgency of these questions. In this paper, we explore the extent to which a political economy…
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The dual role of state capacity in opening socio-political orders: assessment of state capacity in Belarus and Ukraine
Antoaneta Dimitrova, Professor Comparative Governance at Leiden University, Honorata Mazepus, Assistant professor at Leiden University and Dimiter Toshkov, Associate Professor at Leiden University, together with three other authors researched which aspects of state capacity might contribute to opening…