313 search results for “shen barrie repair” in the Public website
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Control of replication associated DNA damage responses by Mismatch Repair
PhD defence
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
PhD defence
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Unravelling molecular mechanisms in transcription-coupled nucleotide excision repair
PhD defence
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Environmental and health impact of informal e-waste recycling
The majority (80%) of e-waste generated globally are recycled informally in developing countries.
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Decolonising International Justice
Around the world, there is a growing movement to decolonise university curricula, with both students and educators seeking to disrupt existing epistemic hierarchies within higher education. This research project aims to unravel what decolonising means in general and what it means for the International…
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Cancer and heredity
Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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Millions of people to help with new synthetic skin cream
A team of researchers has managed to recreate the most natural skin cream in existence. Using the DUBBLE beamline (Dutch Belgian Beamline) at the European Synchrotron Radiation produced on the basis of the information identified, has the same properties as vernix caseosa. This cream may have a therapeutic…
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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About us
The Hazelhoff Centre for Financial Law provides academic education and performs research in the field of financial law.
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Mechanisms underlying mutational outcomes of DNA double-strand break repair
PhD defence
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Host-Microbe Interactions in Plant Sciences
Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…
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Leiden University Medical Center
The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.
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Regenerative medicine: curing patients by regenerating organs, tissue and cells
Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…
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Mark Klaassen advocates for Effective Family Reunification Rights at Red Cross Event
Mark Klaassen presenter at the Reuniting Families: From Access to Integration event organized by the EU office of the Red Cross in Brussels.
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
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Collaborative Crisis Management Before and During International Summits
Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Machine learning and computer vision for urban drainage inspections
Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.
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Macromolecular Biochemistry
Macromolecular Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University, comprising the PIs Marcellus Ubbink, Remus Dame, Aimee Boyle, Lars Jeuken and Anne Wentink.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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The importance of free fatty acid chain length for the skin barrier function in atopic eczema patients
An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.
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Unspinning chromatin: molecular mechanisms of chromatin remodeling
How do you fit two meters of DNA in a tiny compartment and at the same time are able to access the right parts of it at the right times?
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…
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Ancient Egyptian Footwear: An Archeological Analysis
The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.
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Cleveringa Dallaire Critical Conversation Series
In the fall of 2021, Cleveringa professor Roméo Dallaire and world experts shared their thoughts about PTSD, children’s rights, war crimes, humanitarian law, and peacekeeping in a series of conversations about leadership and moral dilemma during times of conflict and crisis.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge
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metal-based chemotherapeutic agents for targeted DNA interactions or DNA repair pathway modulation
PhD defence
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The Routledge Companion to Sounding Art is now available as paperback
In addition to the hardback edition, a paperback edition is now also available of The Routledge Companion to Sounding Art, edited by Marcel Cobussen, Vincent Meelberg and Barry Truax.
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Making and creating with ages-old knowledge
The ability to create objects and structures with our hands has been essential to human development. This ability is something modern society is at risk of losing. Leiden archaeologists gather knowledge about ancient processes of ‘making and creating’ over the centuries, knowledge that helps our current…
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Data science
The majority of scientists, from archaeologists through to zoologists, collect enormous volumes of data. Their massive databases contain large amounts of information which is difficult for humans to filter. With a solid grounding in statistics and computer science, we can develop algorithms for analyzing…
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Fernweh
Crossing borders and connecting people in archaeological heritage management. Essays in honour of prof. Willem J.H. Willems
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Research
Research at the MCBIM group is comprised of the following research themes:
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Personal ornaments: changing identities in the Dutch Neolithic and Bronze Age
Numerous beads and pendants of amber, jet and bone have been found in Dutch Neolithic and Bronze Age context, both in settlements and in graves. Because ornaments are personal items, they are closely linked with people’s identity.
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Plant Sciences
The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…
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Mobility
An estimated 17% of our university's total carbon footprint comes from the thousands of travel movements by our staff, students, visitors, and suppliers. Our aim is to reduce these emissions by a quarter in the coming years.
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Nostalgia for the Present
Ethnography and Photography in a Moroccan Berber Village
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Einstein’s light dances and spins in Leiden
The documentary Einstein’s Light by director Nickolas Barris shows in a dazzling manner what scientific breakthroughs resulted from the special friendship between Albert Einstein and the Leiden physicist Hendrik Antoon Lorentz. The documentary premiered at the Leiden International Film Festival on 2…
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Professor and Knight: Joke Bouwstra Receives Royal Honor
A memorable farewell symposium and a royal distinction: Professor Joke Bouwstra could not have completed her career at Leiden with more pleasure. On Friday, 14 June, she received a Royal Honor from Leiden Mayor Peter van der Velden, who appointed Bouwstra as a Knight in the Order of the Dutch Lion for…
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Data sets
Data sets available for scientific/research purposes.
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Practitioners' Perspectives
Many of the journal's issues contain short contributions from practitioners of diplomacy. These practitioners' essays offer unique insights into the world of diplomacy and they serve as a source of inspiration for researchers.
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The Routledge Companion to Sounding Art
ACPA Professor of Auditory Culture and Music Philosophy Marcel Cobussen and ACPA PhD Supervisor Vincent Meelberg are, together with composer and Simon Fraser University Professor Barry Truax, editors of the recently published Routledge Companion to Sounding Art.
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Prof. dr. Lenstra in tv show 'De Wereld Draait Door'
In the tv show 'De wereld draait door' of Tuesday 4 February, Prof. Hendrik Lenstra, together with Prof. Barry Koren, gave an explaination of the so-called 'Millenium Problems'.
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Two-Day Workshop: Governing Digital Platforms
The GTGC seed grant project on Governing Digital Platforms organised a two-day workshop on 18-19 January 2024, bringing together scholars and practitioners from diverse epistemologies, positionalities, geographic regions, and disciplines – with a focus on ethics and (political) philosophy, anthropology,…