Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

This activity is currently not offered. An (online) alternative is being sought.

The CMCB brings together microbial cell biology expertise in Leiden. It aims at optimal resonance between the groups and maximal exploitation of the available infrastructure and to develop innovative cross-boundary technology platforms.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

The Ig Nobel prize is awarded annually to ten studies that first

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

Promotor: A.W. van der Vaart

The master’s specialisation Biology and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

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Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Each year, poppies disperse seeds that grow into a new generation of flowers. Sometimes, some of the seeds postpone their germination for a few years, for example when they’re covered by a layer of sand. Only when the sand disappears, do they start to sprout. Margriet Oomen did mathematical research…

Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high- or infinite-dimensional models and data.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Lecturer at Leiden University, Mathematical Institute and Institute of Biology, Leiden - the Netherlands

Disseminating to the future generation of researchers the multidisciplinary working practices, expertise and scientific view that has been developed in research within the Plant BioDynamics Lab over the past years is an important objective in our collaborative efforts. The research papers of PBDL bring…

Lisanne Rens has been awarded the 2017 H. D. Landahl Mathematical Biophysics Award. Rens is a PhD student at the CWI (Centrum Wiskunde & Informatica) in Amsterdam and also affiliated with the Leiden University Mathematical Institute.

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

A theoretical project on the insights gained by human (including infant), nonhuman animal and computational studies on artificial grammar learning; identifying the critical questions for future research by developing novel experimental and computational approaches to address these issues.

PhD defence

ISBA2025

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Can cyclic peptides provide a new generation of antibiotics?

Overkleeft

In this dissertation, Boethius’ mathematics and logic and their roles in philosophy are reassessed, and on the basis of these, the connections between mathematics and logic in Boethius and their applications to theological or philosophical topics are explored.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

The research of this programme is centered around dynamical systems, functional analysis, and their interplay.

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

On this page you can learn more about the history of our Faculty Awards and view the previous winners.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

The number of mathematics students in higher education is increasing spectacularly. This year, the influx of new students rises to more than 1000 on a national scale. This is a fivefold increase compared to the number of students that registered for an education in Mathematics in 2002.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel