Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Does a moving hybrid zone leave a genomic footprint?

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

An assessment approach that tailors to children’s instructional needs

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

On May 23rd, Ernanda succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Ernanda on this great result.

Leiden University is working on the renovation of the Humanities Campus. The education buildings are being addressed one by one. Students, staff, visitors, and Leiden residents can then study, work, and live in a pleasant environment. The Humanities Campus is in open connection with the city of Leiden…

Brendan Carroll promoted On Thursday October 30th Brendan Carroll successfully defended his PhD dissertation entitled:

This dissertation provides a description of Konso, a Cushitic language spoken by about 250,000 speakers in the South-West Ethiopia.

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Can we find new chemical and biological sensing routes on the edge and surface of graphene to improve the potential of graphene to act as a sensor?

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

This article discusses the degree of independence that is required for national human rights institutions to function successfully.

Facilitating direct citizen participation through online channels is considered as an opportunity for including harder to reach groups in participation.

Besides the Hortus being a beautiful place where visitors can relax and learn more about plants, we also facilitate botanical research. Thousands of plants are cultivated for research purposes in our greenhouses. These include tropical orchids, ferns, the soursop family (Annonaceae), the dogbane family…

On February 20th, Gulnaz Sibgatullina succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Gulnaz on this great result.

In the Leadership Lab (4 EC) you tackle a topical problem presented by one of our partner organisations and develop important leadership skills in practice.

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

How does invasive hybridization affect threatened native species?

A defining fixture of our contemporary world, video games offer a rich spectrum of engagements with the past.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

Promotor: Prof.dr. M.A.G.J. Orrit

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The main question I want to answer is about the mutual influence between the cultural and settlements changes that occurred between the Bronze and the Early Iron Age in Margiana and the management of water resources.

In higher education, Open Educational Resources (OER) are available for anyone to use, but they are not widely used.

Promotor: A. Doelman, Co-promotor: J.D.M. Rademacher

Although migration and integration have become important concepts today as a result of globalization, migration movements, integration, and multiculturalism have always been part of the history of Europe. Few people realize how many ethnic groups participated in migration within Europe or into Europe…

Promotor: A.P. IJzerman

Over the last decades, income inequality has increased globally. How do social policies affect this increasing trend? How do international trade and technological progress affect inequality? What is the profile of income inequality in China?

Promotor: F.J. van Lunteren, E. Jorin

How does FoxP1 affect auditory perception on a behavioural and genomic level?

In this article, Meier & Nadler suggest that while non-citizen enfranchisement boosts participation across all citizens, citizens with immigration backgrounds are more reactive to the NCV rights in terms of higher turnout. In this way, the paper adds a critical nuance to individual-based explanations…

Terrorist groups adapt to environmental changes to maintain power. This project provides new insights by developing a theory of strategic target selection and using big data analytics and machine learning to test these hypotheses.

The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

Promotor: Prof.dr. M.K. Richardson, Co-Promotor: F. Witte

A new publication on changes in the relationship between news and their public in Chile

On the 16th of September, Bert van Pinxteren successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Bert on this achievement!

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

The principal aim of this research is to explore the confrontation between voice and electronics. These are often seen as being radically different from one another and many characteristics seem to be in opposition between them. However, they also have characteristics in common and they can influence…

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

In this article, Honorata Mazepus, assistant professor at the Institute of Security and Global Affairs, and Dimiter Toshkov, associate professor at the Institute of Public Administration, discuss whether the winner–loser gap extends beyond the political domain to subjective health and well-being as…

Doctoral Thesis

In this article, Dimiter Toshkov aims to explains the gender gap in COVID-19 vaccination attitudes.

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

This volume challenges the idea that the development of ‘democracy’ is a story of rise and progress at all. It is rather a story of continuous but never completely satisfying attempts of interpreting the rule of the people.