Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

On Wednesday 31 August 2022, the graduation ceremony of the BSc Security Studies took place. The ceremony was opened by programme director Daan Weggemans.

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The rise of extremism in Europe has increased polarisation. The EU-funded DRIVE project, led by Tahir Abbas, Professor of Radicalisation Studies from Leiden University’s Institute of Security and Global Affairs, explores how social, structural, and individual factors contribute to radicalisation, offering…

Leiden University is home to over a hundred specialists studying the Middle Ages and the Early Modern period. From 2017-2018 onwards, they will join forces to offer two new options for specialisation within existing MA programmes: Medieval Studies and Early Modern Studies.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Ragazzi, ‘Suspect community or suspect category?‘, Journal of Ethnic and Migration Studies

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

This study aims to examine how South Korea (hereafter, Korea) and Japan, two neighboring countries in Northeast Asia, have been responding to and mitigating the spread of COVID-19.

How can we quantify the density of species within a community through environmental DNA concentrations?

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

The Board of Governors of Leiden University has confirmed the appointment of Professor André Gerrits (Institute for History, currently in the field of Russian Politics and History) to the field of International Studies and Global Politics, commencing October 1st 2015.

This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.

Conference, Workshop

A framework for prospective/ex-ante life cycle assessment (LCA) and ecological risk assessment (ERA) of emerging technologies is developed and applied to a case study of III-V/silicon photovoltaic panels.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Including modelling as part of software development appears to have various benefits.

On the largest scale, the Universe resembles a cosmic spiderweb. Most galaxies coexist in small groups within the threads of this web. At the nodes of the threads are enormous groups of galaxies forming the largest structures in the universe still held together by gravity: clusters of galaxies.

This collection of seventeen essays takes its inspiration from the scholarly achievements of the Dutch historian Jan Lucassen. They reflect a central theme in his research: the history of labor.

This project aims to investigate the underlying (neurocognitive) linguistic processes of ellipsis resolution, particularly gapping.

Tin electrodeposition applications have rapidly evolved in the past 25 years.

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

On the 16th of June Patrtick Harrison successfully defended a doctoral thesis and graduated.

The starting hypothesis of the project is that secrecy is not always inimical to democratic governance as conventional wisdom has it.

On the 24th of September, Louise S. Friis successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Louise on this achievement!

The urban graveyard presents several studies in which the results of older archaeological and osteoarchaeological research are compared to more recent excavation data from several Dutch, Belgian and Danish cities and towns.

The Security Studies bachelor's programme has received a bronze medal in EW Best Studies 2023. Every year, EW Best Studies selects the top programmes in Dutch higher education.

Part of ‘Moralising Misfortune: A Comparative Anthropology of Commercial Insurance’, an ERC Consolidator project of Erik Bähre.

Chinese materia medica (CMM), comprising a diverse array of natural substances from plants, animals, and minerals, has been integral to Traditional Chinese Medicine (TCM) throughout history. This study investigates the dynamic evolution of CMM, noting shifts in species for improved therapeutic effects…

Organised in four separate sessions throughout the day, and broadcast live online to guests and families who could not join, a total of 260 students received their Bachelor’s Diploma of International Studies on 28 August 2020 at the graduation ceremony in the historic Pieterskerk in Leiden.