This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

Viviana Massa defended her thesis on 16 December 2018.

Form and Function in Greek Grammar. Linguistic Contributions to the Study of Greek Literature is a new book, written by Albert Rijksbaron. Rijksbaron is internationally known as one of the leading scholars of the Ancient Greek language, whose work has exerted a strong and lasting influence on the scholarly…

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

When literature, cultural aspects, and data-driven language learning meet in a classroom.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…

The present monograph, spanning a wide range of world and local literatures represents a high academic standard of both literary criticism and philological analysis. By demonstrating her expertise as an Africanist conversant with the Arabic canon, Raia reveals how the narrative of Joseph has been re-narrated…

On the 26th of September, Cosmas Rai Amenorvi successfully defended a doctoral thesis. Leiden University Centre for Linguistics congratulates Cosmas on this achievement!

Natashe Lemos Dekker addresses the experiences of family members of people with dementia as they expressed their sense of gradually losing the person with dementia in the article 'Anticipatory Grief in Dementia: An Ethnographic Study of Loss and Connection' published in Culture, Medicine, and Psychi…

Lecture

The topic of this PhD thesis is teachers' perspectives on self-regulated learning.

This research aims to investigate how different social forces interact with hydropolitics in the Eastern Nile Basin and what are the constraints of engagement.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

This dissertation defends the existence of a type of movement that has so far been considered not to be possible, namely, movement of a bare head to a specifier position over arbitrarily long distances.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

In this thesis the combinatorial use of bioorthogonal labelling and Electron Microscopy (EM)-based imaging techniques is explored to enable observations of specific molecular targets in their ultrastructural context within the cell.

On Wednesday 31 August 2022, the graduation ceremony of the BSc Security Studies took place. The ceremony was opened by programme director Daan Weggemans.

This project aims to develop advanced data analysis methods for monitoring and increasing our understanding on biodiversity dynamics in nature reserves such as the Oostvaardersplassen.

This thesis focuses on the development of sample-preparation methods for small amounts of samples and applying the developed methods to muscle tissues to investigate the mechanisms involved in sarcopenia.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

The rise of extremism in Europe has increased polarisation. The EU-funded DRIVE project, led by Tahir Abbas, Professor of Radicalisation Studies from Leiden University’s Institute of Security and Global Affairs, explores how social, structural, and individual factors contribute to radicalisation, offering…

Leiden University is home to over a hundred specialists studying the Middle Ages and the Early Modern period. From 2017-2018 onwards, they will join forces to offer two new options for specialisation within existing MA programmes: Medieval Studies and Early Modern Studies.

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Ragazzi, ‘Suspect community or suspect category?‘, Journal of Ethnic and Migration Studies

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: H.M. Cuppen, S. Ioppolo

This study aims to examine how South Korea (hereafter, Korea) and Japan, two neighboring countries in Northeast Asia, have been responding to and mitigating the spread of COVID-19.

How can we quantify the density of species within a community through environmental DNA concentrations?

Through a range of case studies spanning the post-Cold War period in Iraq, Moldova and Serbia, this book studies asymmetric conflicts where warring sides exhibit vast power differentials.

This doctoral thesis comprises four studies on the content and structure of physics teachers’ belief systems about teaching and learning physics in secondary education in the Netherlands.