Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

Scientists of the faculty of Governance and Global Affairs research completely different subject, among which terrorism, cybercrime and migration. In the upcoming weeks we will give the floor to several of our very best researchers. In this episode: migration researcher Alexandre Afonso.

Political scientist Nicolas Blarel (Leiden University) analsyses how non-state actors can (directly or directly) attempt to provoke conditions for a crisis between state actors that have nuclear capabilities. He argues that there is an urgent but complicated and understudied task to understand and manage…

China is conducting joint military exercises this week with Cambodia, Laos, Malaysia, Thailand, and Vietnam. In doing so, it is seeking to strengthen military ties with the ASEAN Member States amidst growing US presence in the region.

In a virtual game environment, one of the positive effects of anonymity is the absence of one's prejudice toward others, which can give a person the freedom to change and experiment (Bartle, 2003). This project will adopt anonymity to be added to online cross-cultural collaborative learning in higher…

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.

How do macrophages and neutrophils contribute to metastatic onset?

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

Mechanical forces are known to play an important role in bacterial colonies. In this dissertation, we study the self-organization at various stages of growing bacterial colonies, and focus on the mechanical effects of cell growth.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

In autoimmune diseases such as rheumatism and diabetes the immune system attacks autologous proteins. Leiden researchers are trying to discover how this comes about.

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.

Our Division has created and maintains the Visualisation Core Facilities of the LACDR. This is a multi-user facility offering basic and advanced microscopic techniques to scientists of the LACDR.

The overlapping of intergovernmental organizations sharing Member States is one of the key challenges for achieving effective regional integration.

On 7 and 8 July 2016 the T.M.C. Asser Instituut and the Law Faculty of Leiden University organise a two-day symposium on EPPO.

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

‘Quantum technology is going to change the world, but most people don’t feel connected to it. I want to change that,’ says Julia Cramer, assistant professor at Leiden University. Known for her passion for science communication, Cramer actively seeks opportunities to share the wonders of quantum technology…

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

In 2020, Leiden University launched its stimulated interdisciplinary programs, including one focused on regenerative medicine.

The Hague Diplomacy Podcast aims at bringing the themes of the journal's research off the page, and onto the discussion table. Each episode will feature a guest who will share their insights and personal experience within their practice of or research on diplomacy. Available via SoundCloud, Apple Podcasts…

Watching and analysing hundreds of TEDx talks, that too can be research. That becomes clear from the work of PhD student Aletta Meinsma, who is studying potential problems in popular communication about quantum technologies. She explains how she approaches this and why it is so important.

The US travel restrictions are deeply regrettable. Support will be offered to students and staff who are affected.

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

Image-Pro Plus, ImageJ, Cell Profiler, R, Knime and NIS-elements

The cell observatory equipment is hosted by several institutes. Each of the institutes maintain their own instruments A detailed list of equipment can be found below per institute

This is a facility where research groups or small companies can apply for space if they need to culture human or animal cells.

Computer says no: end of story. Twenty years ago, a hilarious line in the British TV series Little Britain, now a reality. We all blindly follow technology at times, with varying consequences. For ISGA lecturer and researcher Daan Weggemans, it's a subject worthy of a PhD.

Eduard Fosch-Villaronga, Associate Professor at eLaw, presented his work on ‘Aligning rules and actions in digital innovation’ at the conference on Technology and Sustainable Development, This event explored whether technology can be used to fix the very problems caused by technology, encompassing social,…

From 26 to 30 June 2017 a summer course on Europeanisation of administrative law in the Member States of the European Union will be held by the Department of Constitutional and Administrative Law.

This month Johan Christensen, assistant professor at the Institute of Public Administration, published his new book: ‘The Power of Economists within the State’. The book explores four countries, Denmark, Ireland, Norway and New Zealand and analyses why these similarly sized and wealthy countries have…

On 22 June 2018, Prime Minister Rutte announced that Jaap de Hoop Scheffer, Professor of International Relations and Diplomatic Practices at the Institute of Security and Global Affairs (ISGA), together with former ministers Sybilla Dekker and Winnie Sorgdrager, will become Minister of State.

Political scientist Ruud Koole (Institute Political Science, Leiden University) has been appointed to a state commission that will investigate whether the Dutch parliamentary system and the parliamentary democracy need to be reformed.

Physics and Engineering Approaches to Biomedicine and Pharmacology

Promotores: A.H. Meijer, H.P. Spaink

The applications of studying the early development of insects range from agriculture to material science.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Promotor: B. van de Water

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Source: Mediators Inflamm (2014)