In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle, Jeuken or Wentink).

Relevant publications of the CIGR participants.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

The Green algae Chara as model system for intra and inter cellular transport processes.

Marie-Jeanne Holveck and Katharina Riebel from Behavioural Biology at the Institute of Biology at the Faculty of Science published their research in Proceedings B of The Royal Society.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Roeland Merks is appointed as professor Multiscale Mathematical Biology (0.2 FTE) at the Mathematical Institute as from 15 January 2014.

Although Ebola is a virus with significant fatality rates, we still lack effective countermeasures to battle it. To change this, Alireza Mashaghi and his colleagues from the Leiden Academic Centre for Drug Research have successfully developed an organ-on-a-chip model that imitates the most dangerous…

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

The Biology and Education specialisation consists of 120 European Credit Transfer System (EC) points and consists of a Biology component (60 EC) and an education component (60 EC).

Daily management at the Institute of Biology Leiden is executed by the Scientific Director, the Director of Education, the Director of Operations and the Management Assistant. Research and education are managed collaboratively, with strategic input from various representatives and gremia, including…

Afstudeerceremonie

Afstudeerceremonie

Our education programmes span the entire spectrum of Animal Sciences, Evolution, Biodiversity and Conservation, Microbial Biotechnology and Plant Sciences.

The IBL-office welcomes you and will answer all your questions regarding general information, administrative issues, or redirections towards IBL subdivisions and people.

Promotor: B. van de Water

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

An overview of our infrastructure at the SPP division:

Do you have questions about the specialisation Evolutionary Biology? Please contact us!

The specialisation consists of 120 European Credit Transfer System (EC) points and consists of an Biology component (60 - 80 EC) and a science communication component (40 - 60 EC).

Do you have questions about the specialisation Molecular, Cellular and Organismal Biology? Please contact us.

The Biology and Business Studies specialisation consists of 120 European Credit Transfer System (EC) points and includes a one-year biology component (60 - 80 EC) and a business component in the second year (40 - 60 EC).

The ‘Stans Prize 2010’ has been awarded to Leontien Cenin and Lisanne Daniëlle Korpelshoek for their research on impacts of landuse on three migrant harriers in northern Cameroon.

Below are some examples of ACPA projects that have a meaningful impact on arts and society. This page will be refreshed every now and then, presenting projects that exhibit how artistic research can significantly contribute to the way we perceive, understand, and relate to the world and to other pe…

Professor Annemarie Meijer and several students explained to more than 8000 visitors the zebrafish as a model for research during the National Weekend of Science (3-4 Oct) at Science Center NEMO in Amsterdam.

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

The specialisation enables you to understand the fundamentals of management and entrepreneurship alongside high quality Biology research.

In 2020, many of our staff and students have again won prestigious prizes and been awarded important research subsidies.

Festival

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

The logo of Leiden University, with letters as small as a bacterium. Researchers from LUMC and the Institute of Biology have created the smallest logo of our university ever produced. It is a piece of fun with a serious real-world application: the new microscope with which the logo was made allows scientists…

Do you have questions about the Master Biology and Science Based Business? Please contact us!

Disseminating to the future generation of researchers the multidisciplinary working practices, expertise and scientific view that has been developed in research within the Plant BioDynamics Lab over the past years is an important objective in our collaborative efforts. The research papers of PBDL bring…

Do you have questions about the Master's specialisation Biology and Education? Please contact us!

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Promotores: J. Jonkers, K.E. de Visser