The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

What are the functions of the endocannabinoid system?

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.

description that google uses to depict when in presented in search results

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Decision support tool for cell therapy commercialization and business development

Immunologist Leender Trouw specialises in the complement system, which is part of the immune system. In some diseases drugs help activate or inhibit this system. This is best done ‘in the right place at the right time’ − the title of his inaugural lecture.

An overview of research projects at the Predictive Pharmacology group.

PHM offers you the tools to navigate through, and give direction to, the complex and changing health care landscape by using an interdisciplinary approach. Become the broker to improve health and societal outcomes for citizens and patients.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

PhD candidate Maia Casna received an Incentive Prize from the Dutch Association for Physical Anthropology (NVFA). She was rewarded this honor for her innovative research into respiratory diseases and her talent for presenting her results to both academic and general audiences. ‘It feels really nice…

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

How humans and rats cohabit the cityscape and what consequences this has for both sides of the conflict?

The cellular recycling system in zebrafish is capable of eating harmful bacteria and thus resist infections such as tuberculosis and salmonellosis. That is written by Leiden biologists from the group of Annemarie Meijer. Stimulating this form of defence could be used in new treatment methods against…

The Leiden University Medical Center (LUMC) has received a 4m grant for the ECOTIP project. In this project researchers will study how our physical environment affects our health. The aim is to find tipping points: at what point is there a real lack of greenery, healthy food or clean air in a neighb…

Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

The opportunity to explore a new, exciting research topic. That is how Lennart Schada von Borzyskowski describes his successful application for the NWO XS grant. It comprises 50,000 euros, which the researcher from the Institute of Biology Leiden (IBL) will spend on investigating a more sustainable…

Using artificial intelligence to find new antibiotics. With that, researchers from Leiden University are nominated by magazine KIJK for the Best Tech-idea of 2021. From September 14 onwards people can vote to crown one of the nominees as the winner.

Leiden University social scientists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

Do you want to learn how to prevent child problems by optimising caregiving? Would you like to advise parents, professional caregivers and policy makers on caregiving-issues? In that case the master’s specialisation Parenting and Child Development is the ideal choice for you!

In the research theme ‘Animal Sciences and Health’, we work with various animal species to gain insights into fundamental biological processes in both animals and humans.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

On 10 September 2021, Professor Thorbald van Hall from the Department of Medical Oncology in the Leiden University Medical Center (LUMC) delivered his inaugural lecture ‘Tumour-immune interactions: control, escape and counterattack’. Van Hall used the opportunity to describe how - in a similar way to…

Following the terrorist attacks in Paris (November 2015) and Brussels (March 2016), Belgium’s counterterrorism policy has been heavily criticized – domestically and worldwide.

Explaining the origins , patterns and outcomes of crisis management efforts.

On June 9-10 2016 Dr. E. Devroe of the Institute of Security and Global Affairs (ISGA) was invited as a key-note speaker on ‘Intelligence Led policing and community oriented policing’ at the annual meeting of the ‘Organization for Security and Co-operation in Europe’ (OSCE), Transnational Threats Department,…

Research goal: To support the design of technologies (counter-measures and communication measures) for the prevention, interdiction and mitigation of lone actor extremist events (LOEEs), which are hard to anticipate, yet can be highly damaging to local and national communities and therefore must be…

Can SMILE, our multi-component intervention, which combines cognitive-behavioural therapy for insomnia, mindfulness, stress, and lifestyle components, improve sleep quality? Can it also improve mood and quality of life and prevent depression and anxiety in the long term?

The research group on governance of crises studies phenomena, dynamics and actors related to crisis governance. The Leiden University Crisis Research Center (CRC) is part of this Research Group.

Preventing or delaying disease often requires lifestyle changes, which turns out to be difficult. Valentijn Visch and Sandra van Dijk are researching how to help people change their behaviour.

In brain diseases such as Parkinson's and Alzheimer's, proteins clump together to form fibres. ‘Chaperone proteins’ unravel those fibres, but in the test tube biochemist Anne Wentink saw that this can also cause new problems. She is going to find out what happens inside cells to determine what a drug…

Two former Bio-Pharmaceutical Sciences students win the KNMP Student Award this year. Esmée de Zwaan for her research into new therapeutic strategies, Sanne Bakker for a study of bleeding risk associated with the use of antidepressant SSRI. Pharmacy organization KNMP awarded the annual prize on 8 October…

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Jos F. Brosschot has been appointed as a professor by special appointment on the chair ‘psychophysiological mechanisms of stress in daily life’. This chair has been created by the Foundation for Research into Psychosocial Stress.

Behavioral Sciences Mental Health Psychological Disorders - Adult Aggression in Adults Psychological Science Social Psychology Criminology & Delinquency Social Sciences Criminology and Criminal Justice Crime and Crime Prevention Criminal Behaviour and Forensic Psychology Violent Crime Law Criminology…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.