We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

On 26 October, Leiden University held its first online signing ceremony, signing an agreement with China’s top university Tsinghua to establish a joint PhD programme to co-foster young researchers in the fields of astronomy and astrophysics.

Leiden University Libraries has made a large number of unofficial poetry journals from China accessible online in its Digital Collections. This opens up thousands of pages from an internationally unique collection of unofficial Chinese poetry for teaching, research, and the general public, including…

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

PhD defence

Identifying and explaining change in the structure of central state bureaucracies and the determinants of survival of individual public organizations are two closely related areas of research in public administration. We aim to bridge the gap between these two main strands of studies of organizational…

The state should prepare 'lifers' better for returning to society, for example by giving them some control over their own lives. This is the finding of Marieke Liem in her book 'After Life Imprisonment', published on 19 August.

The main interest of this research concerns the beliefs and perceptions of Chinese and Dutch university teachers regarding the role of research in university teaching, and how these beliefs and perceptions can be explained by their cultural, institutional and individual background characteristics.

Leiden University Libraries (UBL) has been able to acquire an extraordinary Chinese manuscript at auction in Hong Kong. It concerns an Imperial Edict (dated 1582) from the Ming dynasty period, at one time part of the former collection of well-known sinologist and author of detective-novels Robert van…

In this study I explore literary structures of identity-formation in the works of assimilated/acculturated Jewish writers: Kafka’s novella “The Metamorphosis” (“Die Verwandlung”, 1912) and David Vogel’s Hebrew novel Married Life. 1929).

Clothes by big Western brands that are on sale in Dutch shops are sometimes made by North Korean workers. The Dutch state is co-financer of a motorway that is being built in Pakistan by exploited workers. These are the conclusions of a report published by the LeidenAsiaCentre on 2 April.

An experimental comparison of the impact of liberal norms on a population residing and socialised within a democracy (the Netherlands) with a population in an autocracy (China) and their respective supports for war with another state shows that the level of liberal norms in the democratic experimental…

A memorable farewell symposium and a royal distinction: Professor Joke Bouwstra could not have completed her career at Leiden with more pleasure. On Friday, 14 June, she received a Royal Honor from Leiden Mayor Peter van der Velden, who appointed Bouwstra as a Knight in the Order of the Dutch Lion for…

A starring role for PhD candidate Andreea Nadaban during the annual meeting of the European Epidermal Barrier Research Network. With her talk about the arrangement of lipid molecules in the upper layer of our skin, she won the award for Best Oral Presentation.

Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Otrar as a Case Study for a 6-10th century Transition Zone

Chip war export restrictions for ASML are most likely in conflict with the Word Trade Organisation’s regulations, claims Anna-Alexandra Marhold. China will certainly contest them.

This dissertation focuses on the production and consumption of a mediation show in China that collaborates with the local Justice Bureau and broadcasts on an entertainment channel—exploring answers to questions raised from the mentioned entertainisation, social and political, and cultural issues.

Last week's referendum about the association treaty with Ukraine received a 'no' from the Dutch public. How will the Dutch government deal with this negative outcome? What are the consequences of the 'no' for the treaty? Antoaneta Dimitrova spoke with the China Daily to discuss the matter.

On September 9th 2009, the study Life Science and Technology (LS&T) celebrates its 10th anniversary. In 1999, a group of enthusiastic pioneers within the Technical University Delft (TUD) and Leiden University (LU) founded a novel study based on the biotechnological expertise of research institutes within…

Dementia is widely considered a progressive condition associated with changes in cognitive capacities, which promotes the idea that people with dementia need to anticipate end-of-life care preferences. There is a growing body of interventions meant to support advance care planning (ACP) for people with…

It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.

How have British cities changed in the years since the Second World War? And what drove this transformation? This innovative new history traces the development of the post-war British city, from the 1940s era of reconstruction, through the rise and fall of modernist urban renewal, up to the present-day…

Last February, Leiden University Libraries (UBL) acquired a rare Chinese manuscript dating back to the Ming Dynasty. Three Chinese Studies students got the opportunity to decipher the edict (dated 1582) during their internships. In this UBLpodcast they share their findings.