The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

How can the Safe and Sustainable by Design (SSbD) framework developed in the SSbD4CheM project facilitate the creation of safer and more sustainable chemicals and materials across various industries?

We aim to provide new insights relating to the spectacular multi-cellular life cycle of streptomycetes and other actinobacteria.

A faculty like ours is a treasure chest of and for languages, culture, and society. In the coming year, we will be making sure these treasures get extra attention, both internally and externally, during Leiden University’s 444th anniversary.

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

Evaluating the environmental consequences of diet changes in the European Union.

Institute of Environmental Sciences (CML)

How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

Urban, Food, Water, Biodiversity, Resources and Energy: these are the main research topics of the Institute of Environmental Sciences. We always strive to be a global leader in our field. And make a real impact with both our research programmes.

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

Kuba funerary art from the Congo River Basin

Leiden University is established in two cities: Leiden and The Hague.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

For thousands of years, societies have fallen under the reign of a single leader, ruling as chief, king, or emperor. In this fascinating global history of medieval and early modern dynastic power, Jeroen Duindam charts the rise and fall of dynasties, the rituals of rulership, and the contested presence…

My artistic practice deals with documents and, more specifically, with the use and the exploration of their narrative potential.

Migration imposes special pressures on the meaning, experience and organization of lifecycle rituals. These pressures are felt most strongly by Muslim migrants to Western Europe. In this innovative study, Nathal M. Dessing examines the effects of migration on the life cycle rituals of Moroccan, Turkish…

Promotor: E.F. Smets Co-promotor: J. Geml

Promotor: Prof.dr. M.K. Richardson

How did Anglo-Saxons reflect on the experience of growing old? Was it really a golden age for the elderly, as has been suggested?

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

Bacteriophages, or phages for short, are the most abundant biological entity in nature. They shape bacterial communities and are a major driving force in bacterial evolution.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Leiden is a real student city and has everything you’ll need to turn your time as a student into the time of your life.

Leiden is a lively university city, brimming with history and boasting a student life that’s tangible just about everywhere.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The research programme Industrial Ecology aims to support the ecological transformation of society and environment towards sustainability. The research subject is Industrial Ecology in its broadest definition, covering environmental systems analysis, and incorporating the social and economic aspects…

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

How do mycobacteria subvert the defenses of host immune cells?

Leiden Law School has a methods portal that offers an overview of the various phases of empirical legal research.

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Promotor: Prof.dr. G.P. van Wezel

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

When do fire making tools appear in prehistory, and how might the use of these tools manifest in the archaeological record?

The principle aim of the project is to study the genesis and the quantitative properties of the Early Roman urban network of the Balkan and the Danube provinces.

Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…