Nature, nurture and neural mechanisms of social emotion regulation in childhood

In this working paper, Dr. Joris Larik provides an analysis of the governance and dispute settlement mechanisms under the Ireland/Northern Ireland Protocol.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Lecture

Promotores: F.H.J. Redig, W.T.F. den Hollander

Without electronics carrying out computational tasks our daily lives would look very different. Devices such as elevators, vending machines, turnstiles, washing machines and even traffic lights use a simple form of electronic computing to switch from state to state. But, what if power supply is not…

From educational adventures in the tropics, students building software for real customers, to bacteria that degrade plastics. Scroll through our highlights on educational innovation and the achievements of our students.

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.

Speakers that have accepted to participate:

Which adolescents are more at risk of developing social anxiety disorder later in life?

How do plant defense genes get activated?

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Can we enhance the capacity of host immune cells to kill mycobacteria via production of reactive nitrogen species?

PhD defence

PhD defence

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

The programme will give you the opportunity to choose from a broad range of topics to study. You will be part of an international multidisciplinary research team at our institute.

Leiden Institute of Advanced Computer Science (LIACS)

The EEA enforcement system includes, in particular, the mechanism pursuant to Article 111 EEA for the settlement of disputes between the Member States with respect to the interpretation and the application of EEA law.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

‘Schiedsgerichte in den Aussenverträgen der EU. Neue Entwicklungen unter Einbezug der institutionellen Verhandlungen Schweiz–EU’, Jusletter 28 May 2018

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

National and international actors have attempted to provide accountability for the events at Srebrenica in July 1995. This research project aims to draw lessons learned from those multiple efforts in assessing whether securing a measure of ‘justice’ for the victims has been successful and how national…

Aluminium-based adjuvants, such as aluminium hydroxide and aluminium phosphate, are well-known for their immune-stimulating properties.

This article devises a framework to assess the degree to which human rights bodies provide duplicating or contradicting recommendations to States. Focusing on the case of torture, it creates an original database of recommendations delivered to 14 countries in the years 2012–2016. Results show that duplications…

Miriam Cohen defended her PhD dissertation entitled “Reparations for International Crimes and the development of a Civil Dimension of International Criminal Justice” on 28 June 2017. She wrote her thesis under the supervision of Professor L.J. van den Herik and Professor C. Stahn.

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

On 14 December, Jouke Tegelaar defended the thesis 'Single supervision, single judicial protection? Towards effective judicial protection in Single Supervisory Mechanism composite procedures'. The doctoral research was supervised by Matthias Haentjens and Willemien den Ouden.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

To what extent does the Law Ombudsperson for Children achieve its goals as intended by the legislator when introducing the law?

Promotor: M.A.G.J. Orrit

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

The Algorithms and Software Technology (AST) research programme performs fundamental research in the areas of algorithm design and analysis.