Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

This open access book explores the role of continuity in political processes and practices during the Age of Revolutions.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Conference

To what extent and how do identity processes influence health behavior?

Who is Economic Man? Every economic paradigm presupposes an anthropology, a theory of human nature. This project explores the anthropologies presupposed and produced by ancient Greek economic texts, and the specific knowledge forms that shape these anthropologies.

How to explain the apparent high success rates of the EU infringement procedures, which are the major tools for enforcing EU law, against the member states?

Promotor: Peter Stevenhagen

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

Delineating psychophysiological endophenotypes of social anxiety disorder

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

PhD at Université de Picardie Jules Verne, Amiens - France

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

When and how does social anxiety develop? How can it go astray in some adolescents? How can we help troubled young people to attend school regularly and return to a normal developmental pathway?

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

Supervisor: Indira Nederpelt

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Are you looking for a research project? We have projects available for motivated 6–9-month internship students with particular interest in organic/polymer synthesis, formulation development, gene delivery, protein delivery, and the preliminairy in vitro screening of drug delivery platforms. Students…

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

On this page, you will find the recordings of the online This Week's Discoveries from May 12, 2020, as well as a list of speakers since October 2015.

The aim of the project is the development of polypept(o)ide-based delivery systems to use siRNA as systemic applicated therapeutic agent against e.g. solid tumors

Do understudied animals contain hidden species?

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Nowadays, most Europeans speak a language belonging to the Indo-European language family. However, very different languages were spoken on our continent before the arrival of the Indo-Europeans. The EUROLITHIC project tries to find answers to the question which languages these were and where they came…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

What are the phylogenetic relationships among the members of speciation bursts?

The applications of studying the early development of insects range from agriculture to material science.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

In this dissertation, the types of context Dutch speakers need to interpret the poly-interpretable word ergens ‘somewhere/anywhere’ are studied.

Combining geometry and number theory. That is what Dr Jan Vonk of the Institute of Mathematics receives a Vidi grant for today. ‘By fusing these two disciplines we may be able to solve a century-old mathematical problem.’

Leiden PhD student Peter Koymans has been declared ‘best mathematics PhD student’ by the Royal Dutch Mathematical Society (KWG). He received the prize at the Dutch Mathematical Congress (NMC) on 24 and 25 April. With his talk about his research into the Cohen-Lenstra conjecture, Koymans left eleven…

Lecture, Com(parative) Syn(tax) Series

Lecture