Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

Leiden University seeks to bring knowledge, academic top talents, and resources from Leiden and China together in mutually beneficial joint research projects that are content-driven, based on existing excellent research.

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

Supervisor: Natalia Ortiz Zacarías

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

An overview of research themes and projects at ABS.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

Urban riots, violent responses by police, drug-related assassinations, child abuse, bar fights: Violence is a core theme in today’s modern society.

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

Supervisor: Gerard van Westen

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

To address major societal challenges, research needs to go beyond the boundaries of traditional disciplines. We believe this starts with education. By exposing students to people from different scientific fields, they learn to deal with diverse perspectives and can broaden their horizons. Professors…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The master’s specialisation Bio-Pharmaceutical Sciences and Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical ind…

The fact that scientists are increasingly better able to access molecular cell and tissue data also brings with it a new challenge: how can scientists find the information they need for research among the vast amount of data available?

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

A cancer pill, preferably without severe side effects, is something we’d all welcome. Is it a matter of time before such a pill is a reality? We put this question to three Leiden researchers and asked how they themselves are contributing to new cancer treatments.

Pharmaceutical research should make more use of data science, says Gerard van Westen, postdoctoral fellow at the Leiden Academic Centre for Drug Research (LACDR). ‘If we want to have better drugs, we should start with data.’

SAILS aims to forge links between the different disciplines at the University and to initiate new academic partnerships.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Dr. Doris M. Jacobs, Lead Scientist at Unilever R&D, Wageningen, The Netherlands.

Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

Chiodo

The Faculty of Science is housed in various buildings situated in the Bio Science Park Leiden.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

Research within COI@Leiden is clustered around two themes: sustainable justice and the courtroom as a social arena. Find out more about each of these projects by clicking on the links below.

The online exhibition 'Art of Captivity' corresponds with the publication of anthropologists Kevin Lewis O'Neill and Benjamin Fogarty-Art Valenzuela's book the Art ofCaptivity (University of Toronto Press 2020).

The Centre for Computational Life Sciences

Medicines are becoming increasingly precise and innovative, but at the same time increasingly expensive. With their innovations, it is up to universities to increase competition, thus causing prices to drop. This is what newly appointed Professor of Biomolecular Analysis Hubertus Irth argues. His inaugural…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…

The European Homicide Monitor (EHM) offers a standardized framework for countries and regions to compare homicide characteristics, patterns and trends.