At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

What are key regulators of plant ageing that can reverse ageing in plants (rejuvenation), and how can we use this knowledge to improve crop plants?

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.

This is an Erasmus+ International Credit Mobility project of the Faculty of Humanities with the University of Hyderabad.

This is an Erasmus+ International Credit Mobility project of the Leiden University Medical Center with Nagasaki University.

The ambition to have flexible learning pathways is about creating possibilities to improve the content and form of students’ learning process, and to link learning to students’ needs. Students who have access to a flexible range of learning pathways can align their university career with their own personal…

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

The Cell Observatory is run by several people some of which have multiple roles. To identify whom to contact for what issue please refer to the list below

Promotor: A. Doelman, Co-promotores: P.J.A. van Heijster; A. Zagaris

Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyper-activated an adverse response takes place and cells die, which may lead to organism-level toxicity such as drug-induced…

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with the Ethiopian Space Science and Technology Institute in Ethiopia.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center and the Faculty of Science with two universities in Indonesia.

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with the University of Havana.

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with two Colombian universities, Universidad Nacional de Colombia and Universidad de Antioquia.

Throughout all domains of life, from bacteria and archaea to eukaryotes, genomes adopt well-organized three-dimensional structures that can change in space and time to accommodate preferred transcriptional programs for environmental adaptation, the maintenance of cellular identity and differentiation…

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

Overkleeft

Key publications of the Aging and Immunity group

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Leiden University takes part in several European research and education projects.

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.

On 16 January 2020, Maaike Wensveen defended her thesis 'Eigen haard is goud waard?'. The doctoral research was supervised by Prof. P. Nieuwbeerta and Dr. J.M.H. Palmen.

In late medieval and early modern times, books, as well as the people who produced and read (or listened to) them, moved between regions, social circles, and languages with relative ease. Yet, in the multilingual Low Countries, francophone literature was both internationally mobile and firmly rooted…

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This is an Erasmus+ International Credit Mobility project of the Faculty of Science with Sichuan University in Chengdu.