Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

The programme group Research Methods and Statistics offers methodological support in many projects in the field of education and child studies.

And its application in deciphering hominin diets in palaeolithic eurasia

The University’s Vision on Student Well-Being outlines how the University plans to promote student well-being in the coming years.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Cyber security is one of the critical challenges in our inter-connected world. Organizations are being constantly targeted by adversaries. Various critical systems become exposed on the Internet. Users can find that their data has been stolen from a company that they were not even aware of.

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

With the dramatic growth of the image data on the web, there is an increasing demand of the algorithms capable of understanding the visual information automatically.

Promotor: Prof.dr. D. Bouwmeester, Co-promotor: M.P. van Exter

To study how planetary systems come into existence we study much younger systems still in formation.

Can animal venoms yield novel antimicrobial peptides?

Our current research focusses on the exploration of the Universe using the neutrino. This neutral, almost massless and only weakly interacting particle can open a window to the distant Universe and also dense regions from which photons cannot escape.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Industrial manufacturing processes, such as the production of steel or the stamping of car body parts, are complex semi-batch processes with many process steps, machine parameters and quality indicators.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

Lecture

More than 5,000 exoplanets have been found over the past couple of decades. These exoplanets show a tremendous diversity, ranging from scorching hot Jupiters, common super-Earths, to widely separated super-Jupiters on the planet/brown dwarf boundary.

Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…

Lecture, Studium Generale

In a new study, we found that when we are exposed to potential harm to the other person, it improves our automatic attentional processes to avoid harm to that person.

Filipino anthropologists Andrea Malaya M. Ragragio and Myfel D. Paluga look back at the groundbreaking Netflix show Trese and what it missed about the stories of Indigenous peoples. They published the article 'What Netflix Got Wrong About Indigenous Storytelling' in the digital Anthropology magazine…

The ICT.OPEN conference had no less than five Leiden highlights. PhD candidate Anna Louise Latour won the pitch prize of 500 euros and PhD candidate Can Wang won the second prize in the Commit2Data poster competition. In addition, Professor Holger Hoos gave the keynote lecture on the first day and Suzan…

On 24 January 2020, eLaw attended the Annual Conference on Privacy and Data Protection (CPDP) in Brussels, Belgium. The overarching theme of the 13th edition was

CWTS Seminar

How to strengthen mutual trust between agencies in the criminal justice system and youth with a migration background or weaker socio-economic position. The Netherlands Science Agenda has awarded 1.5 million euros to a consortium to find out.

The combination of data science and sports is a hot topic. In a talk during the opening of the Academic Year at the Faculty of Science, Professor Joost Kok explained what data analytics can teach us about sports.

PhD candidate Wouter Verschoof-van der Vaart has received the Stichting Elise Mathilde Fonds grant from the Leids Universiteits Fonds (LUF) to work on a research project focusing on the landscapes of the Second World War. ‘We will combine citizen science with deep learning to uncover traces of the c…

A 35-year-old uranium crystal will not disclose its secret: what causes a dramatic phase transition at 17.5 Kelvin? Thanks to a new artificial intelligence approach, half of the possible explanations are excluded, but the definitive answer remains to be found. 'It is very frustrating', says physicist…

To develop a new generation of brain science (and train scientists) focused on explaining complex real-world behavioural patterns.

PhD Research Projects:

PhD defence

PhD defence

Managing Diversity: Supervising Functions in Managing Colonial Workplaces

Provenance and distribution of raw materials

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

In the future, physicians may be able to identify dementia much earlier than they can today because a computer algorithm will be able to predict from brain scans how our memory is going to develop.

The main research objective is to map the cities of Roman Asia Minor in terms of location, size, urban amenities and juridical status, with the specific aim to understand the reasons how this urban settlement pattern arose.

Grammatical gender is famously the most puzzling of the grammatical categories. We have a solid typology of gender systems, yet exciting and unexpected patterns keep turning up which defy easy classification and straightforward analysis. Some of these question, stretch or threaten to cross the outer…

How is the development of physiological responses to social evaluation in adolescence affected by other normative developments, such as pubertal, socio-cognitive and psychosocial development? Are social anxiety and public speaking anxiety associated with characteristic patterns of stress responses…

Radiation can be used to determine the isotope ratio of a skeleton. This provides information about where our ancestors lived and what they consumed. Dr Andrea Waters has developed a revolutionary method that can trace patterns of consumption from tens of thousands of years ago.

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

What is the role of auxin in the initiation and process of somatic embryogenesis?

Research on the global field of museums, heritage, commemoration, consumption and material culture

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

Media all around the world reported about it: the most detailed images yet seen of galaxies, shot by radio telescope LOFAR. The international team behind these amazing results were led by Leah Morabito at Durham University and included three talented Leiden astronomers.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: Dr. ir. S.J.T. van Noort