A novel in vivo model system for studies on glucocorticoid resistance

Depression and anxiety disorders among youth are causing major problems worldwide. The mechanisms involved are still unknown, however. Moji Aghajani – Assistant Professor at the Institute of Education and Child Studies - aims to provide new insights with his research

With tomography it is possible to reconstruct the interior of an object without destroying.

Gianclaudio Malgieri, Associate Professor at eLaw Leiden, was invited as a speaker on two panels at the special CPDP Data Protection Day on 25 January in Brussels, an event co-organised by the European Data Protection Supervisor and the Council of Europe.

The Leiden Ranking – Open Edition is completely transparent. The ranking compiled by the CWTS uses open data and publishes the algorithms that are used.

In this research project, the protection of personal data is compared in eight EU member states: France, Germany, the UK, Ireland, Romania, Italy, Sweden and the Netherlands. The comparison of the countries is focused on government policies for the protection of personal data, the applicable laws and…

PhD defence

Fifty thousand euros in expert knowledge and the title Young eScientist 2019: the National eScience Symposium on 21 November was very successful for computer scientist Lise Stork. She will use the knowledge to develop an application to make historical biodiversity data directly available to research…

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

On 31 May, GTGC Chair Prof. Jan Aart Scholte, together with Carolina Aguerre and Malcolm Campbell-Verduyn, launched their book 'Global Digital Data Governance: Polycentric Perspectives' at the University of Groningen.

Comparison across jurisdictions is one way of assessing the appropriateness of lethal force resulting from the actions of law enforcement agencies. This article sets out a vision for a global use of force monitor that can enable meaningful comparisons between law enforcement agencies. It examines some…

While investigating 16 years of images of young stars from a retired astronomical camera, Leiden master's student Sam de Regt discovered that two of those stars were still enveloped in birth clouds. Never before has anyone captured these two stars in so much detail. He publishes his data-cleaning method…

The relative simplicity of the bacterial cell, short generation times and well defined and inexpensive culturing conditions have significantly contributed to our understanding of many complex biological systems. Yet the workings of the bacterial genome, seemingly impossibly compressed within a tiny…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Morphometric and morphological differences have been used extensively in the past to study domestication of the wolf and the origin of dogs. Certainly before genetic testing was performed, these methods were the only means to diverge both groups. But still now, when aDNA cannot be extracted, morphometry…

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Research in the group Clinical Neurodevelopmental Sciences is focused on understanding and influencing developmental mechanisms in children and adolescents.

Aggression inflicts a huge personal, psychological and financial burden on affected individuals, their relatives, and society at large. Despite large scientific, preventive, and treatment investments, no decrease in aggressive behaviour is seen. By combining interdisciplinary expertise the ACTION consortium…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

A neurobiological perspective on individual differences in social competence

Desafios para a proteção dos conhecimentos tradicionais, dos recursos genéticos e das expressões culturais tradicionais dos povos indígenas no cenário internacional

The Research Network of the European Union Fundamental Rights Agency (FRANET) commissioned Aleydis Nissen and Rik Raedschelders to write the 2022 report on Racism, Xenophobia and Related Intolerance in Belgium.

Lecture

What issues arise in the changing landscape of privacy, identity and data protection?

The universities of Delft, Leiden and Rotterdam are working together to show their students what artificial intelligence (AI) means for their own field. Three AI minors will start in the 2022 – 2023 academic year and will answer questions such as: ‘How best can you use AI in your research discipline?’…

In October 2019, OSCL organised a Hackathon on the ins and outs of MRI datasharing

PhD defence

Neuroimaging research has greatly advanced our insights on how the brain is organized. Now is the time for the next step: Imagine what would be possible when we cannot only map brain-functioning, but use neuroimaging to voluntarily regulate brain-activity!

Proud. We did it. All the Ginis. Open Access. Income inequality and Fiscal Redistribution in 47 countries 1967-2014.

How to strike a balance between the sometimes conflicting stakes of individual, public and private data-producers and data-processors?

By far the majority of users of child sexual abuse networks (or child porn forums as they are sometimes called) on the dark web do not actively communicate there but download illegal material, therefore committing a criminal offence. But they often stay under the police and judiciary’s radar. PhD candidate…

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In populations with a seed-bank, individuals can temporarily become dormant and refrain from reproduction until they can become active again. The repository of all dormant individuals in the population is called the seed-bank. Seed-banks are observed in many taxa, including plants, bacteria and other…

Delineating psychophysiological endophenotypes of social anxiety disorder

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Antibiotics are a class of medicine most people take for granted. But pathogenic bacteria are becoming more and more resistant to our antibiotics, and this poses a great challenge for future treatments. There is thus a great societal need to identify new molecules that can address new targets and be…

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

This study explores the role of linguistic data in the reconstruction of Dolgan (pre)history by analyzing contact-induced changes and using them to infer information about the nature of the contact settings in which they occurred.

Development & Disease is one of the four research themes of the Institute of Biology Leiden.

This project investigates the rich linguistic history of the crucial language groups in East Africa and includes a search for words that indicate earlier lost languages. These outcomes, combined with recent archaeological and genetic research, will contribute to a new understanding of East Africa’s…