Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

Cell adhesion signaling

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

PhD defence

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: A.H. Meijer, H.P. Spaink

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

This article examines how motivational signals in job advertisements relate to public employers’ recruitment success.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Source: Mol Psychiatry (2015)

Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…

The emergence of complex diseases resulting from abnormal cell-cell signaling and the spread of infectious diseases caused by pathogens are significant threats to humanity. Unraveling the dynamic mechanisms underlying cell-cell signaling and infectious disease spreading is crucial for effective disease…

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

Promotor: B. van de Water

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

On November 1st, Min Liu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Min on this great result.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Leonie Vreeke is ready to start a new 5-year project to develop a stepwise treatment specific to very shy young children. Her proposal was granted by ZonMw with nearly € 600.000,-. A PhD student and a research assistant will be appointed to execute this project, together with societal partners such…

For the first time, a group of international and interdisciplinary researchers led by Karline Janmaat and her former MSc Student Chirag Chittar, have tested the several hypotheses on music simultaneously in a modern foraging society during their daily search for tubers – their staple food. They found…

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

Physicists have studied the astrophysical neutrino signal as reported by the IceCube collaboration from a different angle with their ANTARES detector. The Milky Way centre was an obvious prime suspect to be a source, but this hypothesis is now only closer to debunked than confirmed. Publication in Physical…

While the interim ruling passed down by the International Court of Justice did not order a ceasefire, it did state that Israel must take all measures to prevent further victims and genocidal acts in Gaza. South Africa brought the case as it alleges that the war in Gaza constitutes a violation of the…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

A research into for whom, when and why the Cool Little Kids intervention works.

Our team consists of the following members.

PhD defence

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Heart failure is a major health care problem with high mortality.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.