The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

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PhD defence

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Leiden University Medical Center (LUMC) has spent the past five years coordinating an international study of genetic mutations and breast cancer risks. The results will make it easier to determine which genes increase the risk of breast cancer and to what extent. The researchers published their results…

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

We already know a lot about genetics and the risk of breast cancer. But much still needs to be done in breast cancer genetics to improve the prognosis and make sure women at high risk aren’t missed. This is what Professor by Special Appointment Marjanka Schmidt will say in her inaugural lecture on 4…

The immune system plays a paradoxical role in the spread of breast cancer. Some immune cells contribute to metastasis, while other cells can be activated to strengthen the effect of chemotherapy. Kelly Kersten made this discovery in her PhD research. PhD defence 7 February.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

To inhibit proteins that contribute to the growth of aggressive cancer cells, that’s the plan of Professor Bob van de Water and his team. They will receive over 700,000 euros from the KWF Dutch Cancer Society for their research. Researcher Maaike Vreeswijk and pathologist Danielle Cohen are affiliated…

We would like to draw your attention to the following advertisement which was originally disseminated by the Dutch Breast Cancer Foundation, in collaboration with Leiden University

Patients with incurable breast cancer remember more information about their treatment if their doctor is more empathetic during consultations. These are the results of research by psychologists from Leiden University in collaboration with Nivel research institute. Publication in Patient Education and…

Cell biologist Erik Danen has been awarderd a grant of half a million euros to study how tumor cells spread throughout the body en develop drug resistance. This was announced mid-August by the Dutch Cancer Society Fund (KWF).

Leiden Asia Centres

Leiden University has a long and outstanding tradition in the field of public international law.

The Leiden Leadership Centre is a member of the Global Leadership Centres Roundtable (GLCR). The Global Leadership Centres Roundtable is the international network of university-based leadership centres.

If you are from abroad and you want to work at Leiden University, there is quite a lot to arrange.

Study of human cultures using computational approaches

The Centre for Political Philosophy (CPP) at Leiden University is an interdisciplinary platform for political thought. It aims to bring together all those with an active interest in the field from different institutes, branches and fields of study at Leiden University.

Leiden University Centre for Intercultural Philosophy (LUCIP) is housed in the Institute for Philosophy at Leiden University.

Fieldwork is a crucial part of the learning process for students in the Faculty of Archaeology. This includes both fieldwork aimed at collecting archaeological data and materials as well as fieldwork for heritage studies. The Faculty has established a specific centre of expertise to further shape these…

Language connects us! We are here to help you! The Academic Language Centre (ATC) is the language centre of Leiden University. As the oldest university language centre in the Netherlands, we offer language courses in a wide range of languages, both for beginners and advanced students. All courses are…

The Leider Leadership Centre is part of the Institute of Public Administration.

As an alumnus of Leiden University, you receive a 33% discount on membership of the University Sports Centre (USC). The sports centre has facilities in both Leiden and The Hague and offers a wide range of sports including tennis, fitness, yoga and kickboxing.

The language learning resource centre unites all language teaching professionals working at Leiden University: teachers and researchers at the LUCL, ATC, LUCAS, LIAS, and ICLON.

The Centre for Professional Learning (CPL) develops in-depth and challenging programmes for higher educated professionals.

The new sports center, which will also be used as an examination center, will be located at the Campus Square.

Hybrid Intelligence (HI) is the combination of human and machine intelligence, expanding human intellect instead of replacing it. HI takes human expertise and intentionality into account when making meaningful decisions and perform appropriate actions, together with ethical, legal and societal values.…

Leiden University began the construction of a new University Sports Centre in collaboration with the construction and design firm Binx Smartility. The current sports center no longer meets sustainability requirements and is also becoming too cramped. The building will also serve as an examination ce…

Study of human cultures using computational approaches

Africa has a population of 1.5 billion people. By 2050, this number is projected to rise to 2.5 billion. The continent’s impact on the global economy, societies but also on the environment, will therefore increase drastically.

The Leiden Centre for Theoretical Philosophy (LCTP) is a platform for analytic philosophy in a broad sense at Leiden University. Its members do research in philosophy of science, philosophy of logic and metaphysics, with a keen interest in the history of topics such as mind, knowledge, truth, and ti…

Promotores: J. Jonkers, K.E. de Visser

Duaal promoveren Combining a job with PhD research Part time PhD research Getting a PhD while working PhD Candidate Dual PhD Candidate

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