1,273 search results for “patients” in the Public website
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Hypermarker
Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.
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Sensing & Stimulation (MSc)
In order to optimize treatment, it is necessary to closely monitor and manage the patient’s health status by means of ‘precision diagnostics, personalized prognosis and targeted therapy’. The specialisation combines the techniques and applications of these sensing (monitoring) and stimulation techniques.…
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Research
The research carried out within the unit Health, Medical and Neuropsychology investigates the psychological factors of health and disease, and the development of innovative treatment.
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Influence of dissociation on the neural correlates of Emotional Working Memory in Borderline Personality Disorder
How do dissociative states affect the ability to suppress emotional distraction (in the context of a working memory task) in patients with Borderline Personality Disorder?
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Systems pharmacology-based optimization of postoperative morphine treatment
Previous research has found important inter-individual differences in the pharmacokinetics (PK) of morphine in special populations such as children, the morbidly obese or the critically ill.
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AI in Neuroscience: Development of Methods to make Personalized Predictions for Migraine and Stroke from E-Health Sensor Data
The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.
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Systems Pharmacology
The aim of the research programme Systems Pharmacology lies in the development of personalised medicine strategies, and development of new systems-based approaches in translational and clinical pharmacology.
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Modelling metastatic melanoma in zebrafish
Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.
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Topic: Psychosocial consequenses of ICU treatment
In case of serious illness, treatment in the Intensive Care Unit (IC) may be necessary. Intensive care treatments has improved over the years and more and more seriously ill patients are surviving admission to the ICU. This favorable development however has a downside since long-term consequences of…
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Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.
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Quantitative Clinical Pharmacology
The Quantitative Clinical Pharmacology group is led by Prof. Dr. Catherijne Knibbe. Her research group aims to define how to adjust a drug dose in special patient populations such as (prematurely born) neonates or children, obese individuals or critically ill patients. Through combining the statistical…
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Acute and chronic pain after cardiac surgery
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. D. Tibboel (EMC, R’dam)
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Light relief
How can new compounds relieve cancer patients of severe side effects?
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We all BENEFIT: The Ecosystem for Healthy Living
The modification of risk factors and related health behaviors lies at the very core of adequate cardiovascular risk management, yet evidence shows that the majority of people with cardiovascular disease (CVD) fail to achieve a healthy lifestyle in the long term. The main objective of this project is…
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Making the most of the first time a medicine is administered to humans
Collecting as much information as possible about administering a new medicine to people can save a lot of money.
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Influencing your health with your behaviour and thoughts
Psychological processes have a major effect on the course of a disease and the effects of medical treatment. Researchers in the field of Psychoneurobiology examine the interactions between body and mind. They investigate the effects of stress as well as the effect of placebos and nocebos, which can…
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PKPD and disease modelling in therapy development for amyotrophic lateral sclerosis (ALS)
We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.
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Center for Interdisciplinary Placebo Studies Leiden
Het Center for Interdisciplinary Placebo Studies Leiden (IPS) streeft naar een beter begrip van placebo- en nocebo-effecten, hun onderliggende mechanismen en hun mogelijke toepassingen in de klinische praktijk. IPS bestaat uit een groep interdisciplinaire onderzoekers die werken aan de Universiteit…
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Medicine
The Faculty of Medicine
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Research projects
An overview of research themes and projects at ABS.
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Exploratory Data Mining in Multimodal data
The change from a closed institution to an open living environment for patients with late stages of dementia will give the patients more freedom in their day-to-day life. The effect of this change on the patients’ mobility, activity and interaction with others will be assessed with sensor technology…
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Does it still hurt?
The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.
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Routine Outcome Monitoring and Feedback in Psychological Therapies
Kim de Jong, Jaime Delgadillo, and Michael Barkham offer valuable insights in their book 'Routine Outcome Monitoring and Feedback in Psychological Therapies' on how therapists and trainees can use feedback to inform treatment decisions and, ultimately, enhance patient outcomes.
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro
Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Neuropsychology of navigation
What is the neurocognitive structure of human navigation ability? What different types of navigation impairment can be distinguished? How can navigation impairment best be diagnosed and treated? How can tools like serious gaming and virtual reality be used to diagnose and treat navigation impairment…
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Phakic intraocular lens implantation: A life-long patient journey
PhD defence
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Stem cells as cure
Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.
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Cardiac imaging characteristics in patients with COPD: prognostic implications
PhD defence
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Quantitative pharmacology of antimicrobials
Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Statistical modelling of time-varying covariates for survival data
This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.
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Benefit for all – An ecosystem for a healthy lifestyle
The BENEFIT programme is a public-private ecosystem in a national consortium, aiming to support patients with cardiovascular diseases in their own home setting for a long-term healthy lifestyle.
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Optimizing antifungal treatment through pharmacometrics: dosing considerations to enhance outcome
Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Topic: E-health
The research connected to this topic is related to E-health.
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SysMedPD: Systems Medicine of Mitochondrial Parkinson's Disease
The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…
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Refining individualized treatment in older patients with breast cancer
PhD defence
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Psychological factors and patient experiences in musculoskeletal specialty care
PhD defence
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On structural spinal damage in patients with radiographic axial spondyloarthritis
PhD defence
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Opportunities within and after rehabilitation for patients with hearing loss
PhD defence
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Systemic Sclerosis: can we identify patients at risk?
PhD defence
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Patient readiness for shared decision making about treatment
PhD defence
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Optimizing antiseizure medication treatment in glioma patients with epilepsy
PhD defence
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Platelet tranfusions and patient outcomes after cardiac surgery
PhD defence
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Nucleotide excision repair: from molecular mechanisms to patiënt phenotypes
PhD defence
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Profiling Endophenotypes in Social Anxiety Disorder – a family study
The key question addressed in this family study is whether the psychophysiological and neurocognitive abnormalities often reported in SAD patients are heritable and can thus be found in family members of SAD patients as well. Determination of heritability of these deficiencies is essential for endophenotyping.…
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The effect of an Emotional Working Memory training on emotion regulation capacities in Borderline Personality Disorder
Does an Emotional Working Memory Training show a beneficial transfer effect on emotion regulation (reappraisal) capacities in patients with Borderline Personality Disorder?
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…