1,158 search results for “computational modelling” in the Public website
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Computational modeling of cellular dynamics in tumor cell migration
Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.
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Reconstruction and Computational Modelling for Inherited Metabolic Diseases
Accelerating the diagnosis and personalising the management of inherited metabolic diseases.
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cellular and tissue dynamics with cell fate decisions through computational modeling
There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…
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Computational modeling of mycobacterium infection and innate immune reponse in zebrafish
Promotor: Prof.dr. J.N. Kok
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Computational modeling of tumor growth and metastasis and the role of the immune system in tumor destruction
In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.
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Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Computer models chart extensive Caribbean inter-island networks
The precolonial inhabitants of the Caribbean islands communicated, travelled, and exchanged objects and ideas along an expansive inter-island network. New methods of computer modeling shed light on these networks. Emma Slayton is set to discuss her work on this topic at her Defense on the 12th of Se…
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Simulating the prehistoric use of fire through computer models
Archaeologists often use the percentages of heat-affected stone or bone artifacts found at archaeological sites as a way to determine how frequently fire was used by the inhabitants. Andrew Sorensen and Fulco Scherjon have come up with a computer model called 'fiReproxies' to simulate how fires used…
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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Discovering the preference hypervolume: an interactive model for real world computational co-creativity
In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.
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Roy de Kleijn
Faculteit der Sociale Wetenschappen
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations
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Computational linguistics
Computational linguistics uses computational methods to help answer linguistics questions across a variety of topics.
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Computational Biology
Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.
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Adaptive Streaming Applications: Analysis and Implementation Models
Promotor: Prof.dr. E. Deprettere
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Bio-inspired Computing
We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.
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Insights from modeling metabolism and amoeboid cell motility in the immune system
This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.
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MODOMA: A computer-simulated laboratory-approach towards language acquisition
The goal of the MODOMA-project is to create a computer model of language acquisition.
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Foundations of Computing (MSc)
The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.
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Modelling the role of cytotoxic T lymphocytes in tumour regression
Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.
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Natural computing
Research in the natural computing group covers theoretical foundations, the development of new algorithms, and interdisciplinary applications of natural computing methods.
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Franz Wurm
Faculteit der Sociale Wetenschappen
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Natural Computing
Research in the natural computing cluster covers theoretical foundations, the development of new algorithms, and interdisciplinary applications of natural computing methods.
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Computer Systems, Imagery & media
The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.
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Knowledge extraction in the quantum random-oracle model
The aim of this thesis is to present novel techniques for proving cryptographic schemes secure against quantum adversaries. Most results are within the context of an idealized model called the ‘quantum random-oracle model’.
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Optimization of quantum algorithms for near-term quantum computers
This thesis covers several aspects of quantum algorithms for near-term quantum computers and its applications to quantum chemistry and material science.
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The developing infant gut microbiota: mathematical predictions of the effects of oligosaccharides
A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.
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Segments and rules: a comparative study into the computational mechanisms underlying language acquisition
In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…
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Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?
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Computer programming
We see computer programming as an essential skill. It enables you to be self-sufficient in building tools, processing data, visualizing research output, communicating research results, etc. Moreover, it empowers you to make beautiful things.
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Image-based Computational Biology
In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…
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Computational Linguistics
In this theme you will be supplied with a firm background in the core of current computational linguistics and a solid comprehension of its neighboring fields.
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Computational electrocatalysis
This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.
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Computed fingertip touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Computer Science
Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…
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Computer Science
Are you thinking about studying Computer Science? Learn more and watch the videos.
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Stereotyping in Computer Science
LIACS is partner in the project 'Stereotyping in Computer Science.' The project is a collaboration between multiple universities and the Dutch national expert organization on girls/women and science/technology (VHTO), which will investigate the stereotypes that children hold about computer scientist…
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Development of Quantitative Nanostructure Activity Relationship (QNAR) Models Predicting the Toxicity of Metal-based Nanoparticles to Aquatic Species
Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…
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Under Construction. Cognitive and Computational Aspects of Extended Lexical Units
This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.
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Computer Science
PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.
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Hai Lin
Science
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Sebastian Fajardo Bernal
Science
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Constructions Emerging: A Usage-Based Model of The Acquisition of Grammar
This dissertation is concerned with the development of grammar. Starting from a usage-based perspective, which holds that children use domain-general learning mechanisms to acquire the grammatical patterns of their mother tongue, Beekhuizen shows how to operationalize various concepts from this tradition…
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Computational Drug Discovery
Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…
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Computational facilities
Beowulf clusters looking for new frontiers.
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Advances in computational methods for Quantum Field Theory calculations
In this work we describe three methods to improve the performance of Quantum Field Theory calculations.