10,000 search results for “leiden” in the Public website
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Enlightening the Primordial Dark Ages
This thesis is dedicated to the exploration of the primordial dark ages: unknown physics during the earliest stages of the Universe’s expansion that have not yet been directly probed by observations. Cosmic inflation is a burst of exponential expansion of space after the “Big Bang”.
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CD8+ T-cells in atherosclerosis: mechanistic studies revealing a protective role in the plaque microenvironment
Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.
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Law and peace in the work of Hans Kelsen
Law and peace in the work of Hans Kelsen. A re-evaluation of Kelsen’s legal philosophy: legal pacifism as tacit meaning of his Pure Theory of Law
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Education
The programme group Parenting, Child Care and Development carries out general courses within the field of Education and Child Studies and specialised courses within the field of Child and Family Science.
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The impact of sustainable forest management on plant and bird diversity in East Kalimantan, Indonesia
Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters
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Voluntary return and the limits of individual responsibility in the EU Returns Directive
On 10 February 2022, Christian Mommers defended the thesis 'Voluntary return and the limits of individual responsibility in the EU Returns Directive'. The doctoral research was supervised by Prof. P.R. Rodrigues and Prof. P. Boeles.
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On the nature of preverbal Focus in Greek. A theoretical and experimental approach
This thesis aims at contributing to our understanding of the semantic and prosodic properties of object foci in Greek, employing theoretical and experimental tools.
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Barbarism Revisited: New Perspectives on an Old Concept
The figure of the barbarian has captivated the Western imagination from Greek antiquity to the present. Since the 1990s, the rhetoric of civilization versus barbarism has taken center stage in Western political rhetoric and the media. But how can the longevity and popularity of this opposition be accounted…
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The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
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Impact of plant hormones on growth and development of actinobacteria
Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.
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The use of computational toxicology in hazard assessment of engineered nanomaterials
Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…
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De verzamelwoede van Martinus van Marum (1750-1837) en de ouderdom van de aarde
Promotor: F.J. van Lunteren, E. Jorin
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Ana Achúcarro Group - The Early Universe
We explore the particle physics and quantum world at the time of the big bang.
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Protective interventions by local elites in early Islamic Egypt
On 13 September 2023 Eline Scheerlinck successfully defended a doctoral thesis and graduated.
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The formation of complex organic molecules in dense clouds-Sweet results from laboratory
Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.
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Cryptography from quantum uncertainty in the presence of quantum side information
Promotor: Ronald Cramer, Co-promotor: Serge Fehr
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Complex Patterns in Streams
The goal of the project is the development of stream mining techniques for complex patterns such as graphs. We will try to extend the existing state-of-the-art techniques into two, orthogonal directions: on the one hand, the mining of more complex patterns in streams, such as sequential patterns and…
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Human nature and governance: soulcraft and statecraft in eleventh century China
On the 2nd of September Jiyan Qiao successfully defended a doctoral thesis and graduated.
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The Function of Toll-like receptor 2 in Infection and Inflammation
The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.
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Severe behavioral and emotional problems, special education and youth care
Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.
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Transforming Wayang For Contemporary Audiences: Dramatic Expression in Purbo Asmoro’s Style, 1989-2015
Kathryn Emerson defended her thesis on 28 June 2016
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Body and Ki in GiCheon: Practices of Self-Cultivation in Contemporary Korea
Yeonhwa Jeon defended her thesis on 6 July 2017.
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A Brief History of Islam in Europe
Thirteen Centuries of Creed, Conflict and Coexistence
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Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
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Smoothly breaking unitarity : studying spontaneous collapse using two entangled, tuneable, coherent amplifiers
The Copenhagen interpretation of quantum mechanics states that a measurement collapses a wavefunction onto an eigenstate of the corresponding measurement operator.
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Développement phonético-phonologique en fulfulde et bambara d’enfants monolingues et bilingues : étude du babillage et des premiers mots
Cette étude montre que le développement phonético-phonologique en fulfulde et bambara est à la foiscomparable au développement langagier dans d’autres langues du monde et influencé par les caractéristiques phonétiques et phonologiques de ces deux langues notamment au niveau de la phonotaxe.
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Guidance documents of the European Commission in the Dutch legal order
On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).
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Mining the kinematics of discs to hunt for planets in formation
Detecting planets during their formation stages is crucial for understanding the history and diversity of fully developed planetary systems like our own. However, observing young planets directly is challenging because they are often deeply embedded within their host protoplanetary discs, rich in gas…
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The Proliferation of Dissenting Opinions in International Law
On 8 July 2020, Andres Sarmiento Lamus defended his thesis 'The Proliferation of Dissenting Opinions in International Law'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. Y.A.A.S. Radi (UCLouvain).
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From Technological Humanity to Bio-technical Existence
Explores the relationship between technics and humanity, tracing the emergence of a bio-technical conception of existence in contemporary continental philosophy. Suny Press
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Data Centres for Natural Recources and Products
Creating information portals for support of European environmental policy.
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Bakti and Sayan traditions among the Tenggerese people in East Java: the role of indigenous institutions in integrated elderly care development
This research delves into the unique cultural approach of the Tenggerese people, an Indigenous community in East Java, Indonesia, regarding elderly care. It focuses on their traditional practices of bakti (‘filial piety’) and sayan (‘mutual aid’), deeply ingrained in the community's lifestyle and va…
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Dynamic hydrogels as synthetic extracellular matrices for three- dimensional cell culture
Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Multi-Biomarker Pharmacokinetic-Pharmacodynamic Relationships of Central Nervous Systems Active Dopaminergic Drugs
Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.
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Matching, entropy, holes and expansions
In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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"Normal" Feelings in "Abnormal" Worlds, On the Political Uses of Emotion in Science Fiction Manga
Carl Li defended his thesis on 30 June 2015
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Dynamic biogeography – Hybrid zone movement
Does a moving hybrid zone leave a genomic footprint?
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Shy parent, shy child?
Delineating psychophysiological endophenotypes of social anxiety disorder
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Social Dimensions of Crane and Wetland Conservation in African Rural Landscapes: Insights from Kenya, Uganda and Zimbabwe
This thesis focuses on the social dimensions of crane and wetland conservation in rural landscapes in Kenya, Uganda and Zimbabwe.
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Science teachers' knowledge development in the context of educational innovation
The research reported in this thesis is concerned with the knowledge development of a small sample of experienced science teachers in the context of a broad innovation in Dutch secondary education, including the introduction of a new syllabus on Public Understanding of Science.
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.