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2,128 search results for “binding study advies bsa” in the Public website

• Binding kinetics Cell Systems and Drug Safety

  A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

• Prediction of binding kinetics Research project

  Supervisor: Gerard van Westen

• Allosteric modulation and ligand binding kinetics at the Kv11.1 channel Research output

  Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

• Drug-target binding kinetics in vivo Research project

  A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

• The Role of Target Binding Kinetics in Drug Discovery Research output

  Source: ChemMedChem (2015)

• Physicochemical analysis of allosteric binding pockets Research project

  Supervisor: Gerard van Westen

• The ins and outs of ligand binding to CCR2 Research output

  Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

• Sodium ion binding pocket mutations and adenosine A2A receptor function Research output

  Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

• Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo Research output

  Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

• Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors Research output

  The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

• How Electrostatic Interactions Drive Nucleosome Binding of RNF168 & PSIP1 Research output

  The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

• Self-assembly properties and applications of metal-binding peptides and proteins Research project

  It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

• Polyfluorinated bis-styrylbenzenes as amyloid-beta plaque binding ligands Research output

  Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

• Insights into microtubule catastrophes: the effect of end-binding proteins and force Research output

  For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

• Towards improved drug action : target binding kinetics and functional efficacy at the mGlu2 receptor Research output

  During the course of drug discovery translational steps are made.

• The Social Ties that Bind: Unraveling the Role of Trust in International Intelligence Cooperation Research output

  Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

• Quantifying nucleosome dynamicsand protein binding with PIE-FCCS and spFRET Research output

  In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

• 1 (hERG)-induced cardiotoxicity: a molecular insight from a binding kinetics study of prototypical Kv 11.1 (hERG) inhibitors Research output

  Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

• Leiden University modifies BSA regulation for the first year and ends experiment with second year News - 23 May 2016

  Leiden University is ending the experiment with the Binding Study Advice in the second year of the bachelor's programme (BSA 2) with immediate effect. Under the terms of BSA 2, students were required to obtain 90 credits within two years, including their first-year diploma.

• Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary Research output

  The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

• Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists Research output

  Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

• Kabinetsvoorstel voor lager bindend studieadvies: geen goed plan News - 9 May 2023

  De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

• Time is of the essence: investigating kinetic interactions between drug, endogenous neuropeptides and receptor Research output

  Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

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  Christopher Green Assistant Professor

  Faculty of Humanities

• 
  Channa Li Guest Researcher

  Faculty of Humanities

• BSc Security Studies Dossier: Getting started

  On this page you will find all information about the Bachelor of Security Studies that you need as a first-year student.

• 
  Xiao Luo PhD candidate

  Faculty of Humanities

• 
  Philomeen Dol Team Leader / Foreign Language Teacher

  Faculty of Humanities

• 
  Shirley Alexander PhD candidate / guest

  Faculty of Humanities

• 
  Amirardalan Emami

  Faculty of Humanities

• 
  Yujing Tan Lecturer

  Faculty of Humanities

• 
  Nico Kaptein Professor Emeritus Islam in South East Asia

  Faculty of Humanities

• 
  Steven Hagers PhD candidate

  Faculty of Humanities

• 
  Haneen Omari University lecturer

  Faculty of Humanities

• 
  Xiong Xiong PhD candidate

  Faculty of Humanities

• 
  Boudewijn Walraven Professor emeritus of Korean language and literature

  Faculty of Humanities

• 
  Geoffrey Cain PhD candidate

  Faculty of Humanities

• 
  Jurre Knoest PhD candidate

  Faculty of Humanities

• 
  Aihua Li PhD Student

  Faculty of Humanities

• 
  Peter Verhagen University Lecturer Tibetan Studies

  Faculty of Humanities

• 
  Crewe Williams PhD candidate

  Faculty of Humanities

• Parkinson Protein α-Synuclein Binds Surprisingly Strong with Membrane News - 16 December 2015

  Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

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  Hyo Jin Pak Lecturer

  Faculty of Humanities

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  Ab de Jong Professor Comparative Religion and Religions of Antiquity / Scientific director

  Faculty of Humanities

• 
  Maghiel van Crevel Professor of Chinese Language and Literature

  Faculty of Humanities

• 
  Aimee Boyle Assistant professor / Guest

  Science

• 
  Henk Schulte Nordholt Professor emeritus Indonesian History

  Faculty of Humanities

• 
  Pao-Yi Yang Lecturer

  Faculty of Humanities

• 
  Maaike Smit-Beemsterboer Study adviser

  Faculty Governance and Global Affairs

• Leiden study system About our education

  Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.