10,000 search results for “leiden” in the Public website
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Guidance documents of the European Commission in the Dutch legal order
On 11 February 2020, Clara van Dam defended her thesis 'Guidance documents of the European Commission in the Dutch legal order'. The doctoral research was supervised by Prof. W. den Ouden and Prof. J.E. van den Brink (UvA).
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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Phenoconversion
Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…
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Chinese Final Particles and the Syntax of the Periphery
In this research, for the first time a detailed description as well as systematic and comparative analysis of the final particle system in Chinese are provided.
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Multi-objective mixed-integer evolutionary algorithms for building spatial design
Multi-objective evolutionary computation aims to find high quality (Pareto optimal) solutions that represent the trade-off between multiple objectives.
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Boosting the host immune system to fight tuberculosis
New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.
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How Terror Evolves: The Emergence and Spread of Terrorist Techniques
This book contextualizes the use of terror as part of wider movements of political contention, demonstrating that terroristic innovation occurs as part of wider historical processes rather than in a vacuum.
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Politics, Culture and National Identities 1789-present
Politics, Culture and National Identities investigates a wide range of national political cultures in Europe and the Americas in the 19th and 20th centuries.
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Functional xylem anatomy: intra and interspecific variation in stems of herbaceous and woody species
My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.
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Exploring the magnetic, turbulent Milky Way through radio waves
Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: Dr. M. Haverkorn
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Dynamic biogeography – Hybrid zone movement
Does a moving hybrid zone leave a genomic footprint?
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Towards a single-molecule FRET study of Frauenfelder's nonexponential rebinding of CO in myoglobin
Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.
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Project schedule
The area will undergo major changes, in a phased plan. Teaching will continue during this period. The existing education buildings will be tackled one by one. Some of the buildings will be reconstructed, and for others the building shell will undergo renovation. The Humanities Building is expected to…
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Modeling interactions to unravel biomarkers for disease progression and treatment response
The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets
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A Grammar of Tagdal
On the 21st of September, Carlos Benítez-Torres successfully defended a doctoral thesis. The Leiden University Centre for Linguistics congratulates Carlos on this achievement!
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Collected Cases on EU Labour Law
European labour law has an unmistakable influence on national law. This applies even more to the case-law of the Court of Justice of the European Union (CJEU), as it has implications for the application of European law in the Member States and with it the interpretation of national law. Collected Cases…
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Science teachers' knowledge development in the context of educational innovation
The research reported in this thesis is concerned with the knowledge development of a small sample of experienced science teachers in the context of a broad innovation in Dutch secondary education, including the introduction of a new syllabus on Public Understanding of Science.
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The town, its waste and the cesspit
The rise and fall of the cesspit in an urban context
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A blessing in disguise?! Discretion in the context of EU decision-making, national transposition and legitimacy regarding EU directives
This dissertation looks into the role of discretion granted by EU directives (Article 288 Treaty on Functioning of the European Union) in legislative decision-making and national transposition processes of these directives.
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Structural Properties of Single Server Queueing Systems: Efficient Methods via Lumping and Dynamic Programming
This thesis consists of two main parts. The first part (Chapters 2 and 3) deals with a class of Markov process called Quasi-Skipfree (QSF) processes.
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The Proliferation of Dissenting Opinions in International Law
On 8 July 2020, Andres Sarmiento Lamus defended his thesis 'The Proliferation of Dissenting Opinions in International Law'. The doctoral research was supervised by Prof. L.J. van den Herik and Prof. Y.A.A.S. Radi (UCLouvain).
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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The Layered Heart: Essays on Persian Poetry, A Celebration in Honor of Dick Davis
The Layered Heart : Essays on Persian Poetry is published in celebration of the poet and scholar Dick Davis, dubbed “our pre-eminent translator from Persian” by The Washington Post.
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Laboratory studies of Water Ice in Space
Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.
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A novel formulation for skin barrier repair : from ex vivo assessment towards clinical studies
The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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The holographic glass bead game: from superconductivity to time machines
Promotores: Prof.dr. J. Zaanen & Prof.dr. K.E. Schalm
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Collective violence offenders and offending. The role of individual characteristics
On 29 September 2020, Tom van Ham defended his thesis 'Collective violence offenders and offending. The role of individual characteristics'. The doctoral research was supervised by Prof. A.A.J. Blokland, Prof. O.M.J. Adang (RUG) and Prof. Th.A.H. Doreleijers (VUMC).
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Hypermarker
Developing a clinical decision support tool that will make it easier for clinicians to personalise the treatment for patients with high blood pressure. The team is using AI, deep learning methods and patient cohort data from 11 European countries.
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Photothermal circular dichroism studies of single nanoparticles
In this work, we investigate the minute circular dichroism effects of single nanoparticles.To this aim, we apply photothermal imaging with a polarization-modulated heating beam.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Photosynthetic light reactions at the gold interface
Promotor: Prof.dr. T.J. Aartsma, Co-promotor: R.N. Frese
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The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age
On 27 June 2019, Barry Bussey defended his thesis 'The Legal Revolution Against the Accommodation of Religion: The Secular Age v. The Sexular Age'. The doctoral research was supervised by Prof. dr. P.B. Cliteur.
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Veluwe
In 2019 citizen scientists inspected elevation maps of the Veluwe region and discovered several thousand potential new archaeological structures. The project started as exploration into the potential of citizen science in Dutch archaeology, but developed into a fully flexed project in which citizen…
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Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society
On 23 October 2019, Yoram Stein defended his thesis 'Spinoza's Theory of Religion: The Importance of Religion in Spinoza's Thought and Its Implications for State and Society'. The doctoral research was supervised by Prof. P.B. Cliteur and Prof. A.A.M. Kinneging.
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'Recycling the past' Tzu-chi waste recycling and the cultural politics of nostalgia in Taiwan
On the 8th of September Yun-An Olivia Dung successfully defended a doctoral thesis and graduated.
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Assessor-Centered Translation Quality Assessment: A Theoretical Model and a Case Study
Behrouz Karoubi defended his thesis on 15 June 2016
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Progressive Indexes
Interactive exploration of large volumes of data is increasingly common, as data scientists attempt to extract interesting information from large opaque data sets. This scenario presents a difficult challenge for traditional database systems, as (1) nothing is known about the query workload in advance,…
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.
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Cyber agent technology and intelligence agencies
Cyber agent technology and intelligence agencies is a project that is commissioned by Tracks Inspector, a Dutch company that develops innovative software.
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Identifying the origins of galaxy formation
This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.
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Clinical Psychology
Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Immigration and the Transformation of Chinese Society
This project is a three-year collaborative research between European and Chinese researchers (2015-2018). As a part of the China-Europe “Understanding Population Change” Collaborative Research Initiative, the project utilizes multidisciplinary research methodologies (social and cultural anthropology,…
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'Authentic Islam': The Religious Profile of Taqī al-Dīn al-Hilālī (1893-1987) as Reflected in his Fatwas
Abdessamad El Amraoui defended his thesis on 6 Mai 2015.
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Mechanisms and consequences of horizontal gene transfer in cell wall-deficient cells of Kitasatospora viridifaciens
The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…
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Modification and Reference in the Chinese Nominal
This study proposes a theory for the encoding of specificity and definiteness in the Chinese nominal based on Cantonese, Mandarin and Wenzhou data.