A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

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This page is under construction.

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

Promotores: H.W. Lenstra, A. Lucchini

Science, Leiden Institute of Chemistry (LIC)

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

During adolescence, mood disorder onset peaks. Mood variability is associated with negative mental health outcomes, so understanding biological factors that might be associated with mood variability, such as sleep and structural brain development, could elucidate the mechanisms underlying mood and anxiety…

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: Dr. J.H. Evertse

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

Children and adolescents really do use their ‘smart’ brain areas. This has been confirmed by an extensive and long-running study of the brain carried out by developmental psychologist Sabine Peters . Her findings can have important consequences for education. PhD defence 27 January.

On 12 April 2022 Alok Oak successfully defended a doctoral thesis and graduated.

Science, Leiden Institute of Advanced Computer Science (LIACS)

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

If X is a locally compact Hausdorff space, then a representation of the complex C* algebra C_0(X) on a Hilbert space $H$ is given by a spectral measure that takes its values in the orthogonal projections on $H$.

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Novel language learning activates different neural processes than was previously thought. A Leiden research team has discovered parallel but separate contributions from the hippocampus and Broca's area, the learning centre in the left hemisphere. The right hemisphere of the brain also seems to play…

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

What are the functions of autophagy in the filamentous fungus Aspergillus niger?

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

Supervisor: P.J.J. Hooykaas

This publication by Cornelis van Tilburg, will be published at Sidestone Press on September 28, 2022. It discusses various aspects of city gates in the Western Roman Empire: Italy, Spain, Gaul, Germany and Britain.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

Managing Diversity: Supervising Functions in Managing Colonial Workplaces

Our childhood years largely determine how we will fare later in life. In the first two decades of our life, our brain is still developing, which is clearly reflected in our behaviour. By studying how the young brain develops and how children behave, researchers can learn important information about…

Assuming everywhere good reduction we generalize the class number formula of Taelman to Drinfeld modules over arbitrary coefficient rings.

Jens Iverson, Assistant Professor of International Law and a Researcher in the Jus Post Bellum Project, defended his Ph.D. dissertation on 21 September 2017.

A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Advanced sensing techniques require graphene with high quality and well-controlled surface chemistry.