702 search results for “soil barrier repair” in the Public website
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Morphogenesis and heterogeneity in liquid-grown streptomyces cultures
The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.
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Development of life cycle assessment for residue-based bioenergy
Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs
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Four Leiden researchers awarded Rubicon grants
Four promising young researchers will be able to conduct two years of research at a university abroad thanks to a Rubicon grant from the Dutch Research Council (NWO). The Leiden laureates are Renske Janssen, Girija Josh, Anne van der Meij and Yana van der Weegen.
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Difference in microbiota between organic and conventional dairy farms
Bacteria and fungi on organic dairy farms are significantly different from those on conventional farms. That was discovered by postdoc researcher Sofia Gomes and her supervisors Nadia Soudzilovskaia and Peter van Bodegom in collaboration with the Louis Bolk Institute and Naturalis Biodiversity Centre.…
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Hybrid zone dynamics in amphibians
Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.
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OSCoffee: Open Science in Criminology - barriers and opportunities
Lecture
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John van Noort Lab - Chromatin Dynamics
Chromatin is an ubiquitous protein-DNA complex that forms the structural basis of DNA condensation in all eukaryotic organisms.
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The development of molecular tools for investigating NAD+ metabolism and signalling
Nicotinamide adenine dinucleotide (NAD+) is the substrate used for the introduction of the ubiquitous and highly dynamic PTM in which either one or multiple adenosine diphosphate ribose (ADPr) moieties are covalently attached to a nucleophilic side chain of an specific amino acid in the target protein…
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Phase behavior of skin lipid mixtures: the effect of cholesterol on lipid organization
The lipid matrix in the stratum corneum (SC), the upper layer of the skin, plays a critical role in the skin barrier. The matrix consists of ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs).
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Non-take-up of social support and the implications for social policies
This dissertation takes an important step in understanding the phenomenon of non-take-up of social support and what it means for contemporary social policies.
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Organising public sector AI adoption: Navigating between separation and integration
In this article, Friso Selten and Bram Klievink explore how public organisations strategically manage the adoption of AI.
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Highly Accurate Simulations and Benchmarking of Molecule-Surface Reactions
Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.
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Oort
Niels Bohrweg 2, Leiden
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Lipid mediated colloidal interactions
The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.
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MicroGRICE: Greenhouse Gas Reduction in RICE: MICRO-biome climate smart applications
Can we use indigenous microbial rice communities to reduce methane production in agricultural settings?
- OSCoffee: Open Science in Criminology - barriers and opportunities
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Access to Justice in Libya (A2JiL)
This 48-month project is to contribute to a solid, accessible, domestically owned knowledge base for people-centred interventions aimed at strengthening access to justice in Libya (A2JiL), and to disseminate such knowledge among stakeholders, enhancing awareness and the capabilities required to provide…
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Food
The research within the Food research programme at CML focuses on a transition towards sustainable food production and consumption systems. We investigate from a very small to a very large scale, at a local, national or international level. We do so by researching for example molecular tools, food systems,…
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Imaging the (un)imaginable of the Barrier Immune System
PhD defence
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Breaking barriers: unraveling response mechanisms to immunotherapy in breast cancer
PhD defence
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The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead
On 15 February 2022, Morshed Mannan defended the thesis 'The Emergence of Democratic Firms in the Platform Economy: Drivers, Obstacles, and the Path Ahead'. The doctoral research was supervised by Prof. I.S. Wuisman and Prof. J.A.A. Adriaanse.
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Microfluidic 3D cell culture for high throughput screening
There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.
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Engineering of antigen-saving dissolving microneedles for intradermal vaccine delivery
The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.
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Annual report CML 2016
In 2016, CML published over 90 papers, successfully crowdfunded the Living Lab project, celebrated a royal honour for associate professor Hans de Iongh and contributed to the Global Soil Biodiversity Atlas. CML awarded five PhDs and taught students from all over the world how to contribute to sustainability.…
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Ecotox
Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in AOPs (adverse…
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Mechanisms underlying mutational outcomes of DNA double-strand break repair
PhD defence
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Anna van Buerenplein
Anna van Buerenplein 301, The Hague
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Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.
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Regenerative medicine: curing patients by regenerating organs, tissue and cells
Regenerative medicine is a new way of treatment that helps impaired cells, tissues, and organs work well again. We do this by repairing, replacing, or restoring cells, tissues, and organs after damage from illness or injury. This includes treating long-term diseases such as diabetes, kidney diseases,…
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Knowledge from now
Osteoarchaeologists help forensic scientists solve crimes. They also study bone material from the Second World War in order to identify victims.
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Biodiversity
Biodiversity is under pressure worldwide, but is essential for our health, food security and well-being. What is the influence of human actions on ecosystems? Can we provide biodiversity-inclusive solutions for our key societal challenges? These questions are central to the Biodiversity research the…
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Institute of Environmental Sciences (CML): best institute for quantitative environmental issues
A liveable planet. More biodiversity. And resources which are being managed wisely. At the CML, we want to make an impact with our research and education. On this website you can read what we do to achieve that.
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Specificity and side-effects of mutagenesis by CRISPR/Cas9 -induced breaks in plants
Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Collaborative Crisis Management Before and During International Summits
Peak Performance: Collaborative Crisis Management Before and During International Summits. This comparative case study probes into conditions for collaborative governance in the security organisation of international summits.
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Machine learning and computer vision for urban drainage inspections
Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.
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Manipulating carbon nanotubes Towards the application as novel field emission sources
Promotor: Prof.dr.ir. T.H. Oosterkamp, N. de Jonge
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Tilling and manuring prehistoric and early historic fields in western Europe
Since the adoption of agriculture people have cultivated fields. The project concerns all kinds of aspects related to raising crops.
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The use of animal manure by prehistoric and early medieval farmers
Did early farmers deliberately use animal manure on their fields?
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
- ELS lab meeting - Journal Club: What went wrong? Methodological barriers to ELS by Jessie Pool
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Spatial (3-D) CNS drug distribution in vivo
Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3-dimensional anatomical organization of the CNS.
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Open Science Monitor – Study on Open Science: monitoring trends and drivers
The aim of this study is to further develop the Open Science Monitor, which started as a pilot study.
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Maastricht-Belvédère
Stratigraphy, Palaeoenvironment and Archaeology of the Middle and Late Pleistocene Deposits.
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LMUY
Einsteinweg 55, Leiden
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Holocene Paleoenvironmental Evolotion of a Perimarine Fluviatile Area
Geology and Paleobotany of the Area surrounding the Archaeological Excavation at the Hazendonk River Dune (Western Netherlands).
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Gorlaeus Building
Einsteinweg 55, Leiden
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Multi-objective Evolutionary Algorithms for Optimal Scheduling
Multi-objective optimization is an effective technique for finding optimal solutions that balance several conflicting objectives. It has been applied in many fields of our world, because practical problems usually have more than one desired goal. For example, developing a new vehicle component might…
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Ancient Egyptian Footwear: An Archeological Analysis
The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.