Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Social resilience and security has never been more important. Over the last 2 years, the COVID-19 pandemic has created a considerable disturbance to our personal and social lives. As a result, the general population reports more stress, loneliness and decreased quality of life. At the same time, there…

New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…

This article written by Marieke Liem & Alexander Kamprad investigates the relationship between terrorism and interpersonal violence. They conducted cross-national analyses on the effects of terrorism mortality rates on homicide rates. Results showed that terrorism appears to be robustly and positively…

Lecture

Can we distinguish the effects of pesticides from other abiotic and biotic factors that occur in the field? And how do these factors interact with pesticides?

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

Freshwater and brackish water ecosystems are arguably the most vulnerable ecosystems on earth, due to concentrated human developments in and around them. The Pontocaspian (PC) region located at the border of Europe and Asia contains a variety of brackish water ecosystems and unique inhabitants, known…

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

In this project, we seek to assess, map and understand the risk factors associated with fatal domestic violence.

Child homicide is a phenomenon that not infrequently leads to shock and societal unrest. However, the precise nature and scope of child homicide in the Netherlands remains unknown.

The general aim of the project is a description and analysis of the Leiden anatomical collections from a humanities perspective. The project investigates how historical and cultural practices and concerns have shaped anatomical preparations and how exhibitions of the anatomical body have informed cultural…

These are the coaches connected to the EmPhD project:

The Institute of Security and Global Affairs (ISGA) hosts two research journals and publishes the ISGA Reports series. Besides its own publications, researchers at ISGA also publish books or journal articles elsewhere. You can find all these external publications under Research output on the right.

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Marieke Liem, Professor Social Resilience and Security at Leiden University, and Katharina Krüsselmann, PhD candidate at Leiden University and Manuel Eisner mapped the flow of homicide cases with the help of a systematic review.

This article describes the phenomenon of firearms violence and the importance of including non-lethal firearms violence in understanding this phenomenon.

How many men and women die per year at the hands of others? What are the motives behind these killings? Are there as many homicides today as years ago? How can we explain the rise and fall of homicides over time? And: What is the influence of (early) childhood and adolescence on the likelihood to commit…

With the recent rise and fall of IS, academics and policy makers around the world are expressing concerns about the fate of children of former foreign fighters. Will they follow in their parents’ footsteps? In this paper, Layla van Wieringen, Daan Weggemans and Marieke Liem argue that in light of this…

Sexual homicide is a rare phenomenon. Yet, sexual killing is widely reported on in the media. Even though academic research on sexual homicide is conducted abroad, in the Netherlands such research is virtually absent.

Homicide followed by the suicide of the perpetrator often leads to shock and incomprehension. It has been suggested that media reporting on such cases could lead to an imitation effect.

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Can the pink-pigmented microbe Methylobacterium extorquens be genetically engineered to convert the sustainable raw material methanol into antibiotics?

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?

Evolution is all around you every day. This is the message of a Massive Open Online Course (MOOC) of Leiden University and Naturalis that is offered free of charge to anyone interested.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

How does invasive hybridization affect threatened native species?

Experts and initiatives related to Academia in Motion (AiM) regularly appear in the media. Below are some examples of news coverage to date.

This study is the first to directly relate brain development to sex differences and school performance. The results debunk the myth that brain development is slower in boys.

The central question in this study is: ‘What can the Netherlands learn from the way in which these countries have organized law enforcement and the rule of law in their overseas territories?’

How can zebrafish research help understanding human diseases?