8,440 search results for “development ” in the Public website
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Live or let die: the intracellular fate of pathogenic mycobacteria
How do mycobacteria subvert the defenses of host immune cells?
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Spreading the Fire: Why is Pyroptotic Cell Death Contagious?
The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…
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Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
- De Novo Cyclic Peptides: A RaPID Approach to Chemical Tool Development
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Van Marum Colloquium: Developing New Paradigms for Applied Catalytic Surface Science
Lecture
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Access to Justice in Indonesia
How do poor and disadvantaged Indonesians address the injustices they face in daily life and how can their situation be improved?
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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LIC Lecture: 3D Domain Swapping of Proteins: Basics and Recent Developments
Lecture
- Open Science Coffee: Developing tools and practices to promote open and efficient science
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Turning academics into researchers: The development of National Researcher Categorization Systems in Latin America
Seminar
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Van Marum Colloquium - Development of materials for hydrogen production via ethanol reform
Lecture
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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COMMUNITY: unraveling the regulatory networks in Streptomyces that switch on antibiotic production on demand
Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics
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Understanding plant transgenesis
How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?
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Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
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Heterogeneity in spores of food spoilage fungi
This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.
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Advances in clinical development for vaccines and therapeutics against respiratory virus infections
PhD defence
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Development and application of cryo EM tools to study the ultrastructure of microbes in changing environments
PhD defence
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LED3 Chemical Biology Talk: Towards the development of orally available peptide therapeutics
Lecture
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cortical, nerve, and muscle excitability in early phase clinical drug development
PhD defence
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Development of Machine Learning-Derived Digital Biomarkers for Trial@Home Clinical Trials
PhD defence
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Developing Sesotho as medium of instruction at tertiary level - challenges and opportunities
Lecture, Applied African Linguistics
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against antimicrobial resistant bacterial infections - next stage development of antimicrobial peptides
PhD defence
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The Sand Motor - Building with Nature to optimise coastal protection and other ecosystem services
How can mega sand nourishments, such as the Sand Motor, be designed and managed for optimal ecosystem services provision ?
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Brain connections predict adolescent impulsiveness
There is a link in adolescents between brain connections and impulsiveness. Leiden researchers have discovered that these connections also predict which adolescents will make more impulsive choices two years further on.
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Novel immunomodulatory drugs for tuberculosis treatment
Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?
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TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
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Translating science into treatments of rare metabolic disorders
Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.
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Using sensors to measure playground dynamics
Free playtime and physical play are of great importance to children's social development. That is the main conclusion of innovative research by developmental psychologists and computer scientists from Leiden University.
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Erik Danen part of NWO Perspectief grant for organ-on-chip
A consortium of research groups, including that of LACDR professor Erik Danen, will use an NWO Perspective grant of nearly five million euros to build a universal standard for organ-on-chip models. They aim to stimulate the application of these chips in the biomedical and pharmaceutical industry. Danen…
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Pharma company Janssen expands premises on Leiden Bio Science Park
Pharma company Janssen has begun construction on a new office and lab building at the Leiden Bio Science Park. The first pile of the 13,500 square metre building has been driven into the ground.
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The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
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Zebrafish personality, stress physiology and behaviour in the context of sound exposure
To what extent is sound a stressor to fish? And are behavioural and physiological phenotypes equally sensitive to disturbance by noise pollution?
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Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
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Environmental and genetic drivers of wood and lignin formation in flowering plants
In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.
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Vici grant for Bernet Elzinga
Bernet Elzinga (Clinical Psychology) is one of the seven scientists from the Leiden University who has received a Vici grant of 1.5 million euros from NWO. Vici is one of the largest grants for individual scientists in the Netherlands. The funding will enable her to do research for the next five years…
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Versatile SNP genotyping
The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…
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Six million boost to search for new antibiotics
Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.
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Annemarie Meijer new training coordinator in European network
The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Sharing personal health data
Comparing individual health data with group data allows doctors to give personalised advice and patients to learn from one another's experiences. Wessel Kraaij, Professor of Applied Data Analytics, shows how personal data can have a valuable predictive function. Inaugural lecture 24 February.
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Microbes protect crops from microbes
Farmers do not love them all. Microbes can cause tragic consequences for crops. Even the presence of just one pathogenic fungus or bacterium can drastically reduce yields. Still, there are exceptions. In that case, a pathogenic microbe is present in the soil, but does not cause any harm. Adam Ossowicki…
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Leiden biology appreciated with large NWO grants
A Vici grant and a Science-GROOT: scientists from the Institute of Biology Leiden have been awarded prestigious grants from the Dutch Research Council (NWO). From investigating bacteria without cell walls to harnessing plants with the help of microorganisms.
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Education Policy for Botswana: Will it Make Local Languages a Social Development Resource?
Lecture, Applied African Linguistics
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‘Take medicine target saturation into account’
Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…