710 search results for “genetics he modification” in the Public website
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Laminar Technology and the Onset of the Upper Paleolithic in the Altai, Siberia
The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.
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Bioactive Molecules in Microbial Sciences
Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Azafaros is valorizing a library of compounds
The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.
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Vision
The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.
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Dynamic biogeography – Hybrid zone movement
Does a moving hybrid zone leave a genomic footprint?
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Aquatic eDNA: Beyond Species Presence
As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.
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Targeted Therapy for Triple-Negative Breast Cancer
The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.
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Explant cultures of atopic dermatitis biopsies maintain their epidermal characteristics in vitro
Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.
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Career preparation
Leiden University offers you several services related to career orientation and job application skills.
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Applied Mathematics (MSc)
The master's specialisation Applied Mathematics at Leiden University focuses on both computational and fundamental aspects of analysis and probability. It’s also an ideal basis for a PhD degree. Applied Mathematics is an excellent choice if you have the aspiration to pursue a PhD degree
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Resolving rapid radiations
What are the phylogenetic relationships among the members of speciation bursts?
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Prepare for your studies
You’ve been accepted! Leiden University looks forward to welcoming you as a new student. Your next step is to prepare for your studies. Below you can find some tips to help you get a head start as you embark on your studies at Leiden University.
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Language as a time machine
By studying language you can reconstruct the history of different communities, even when no other historical sources, such as written documents, are available. In the coming years, researchers Willem Adelaar and Marian Klamer will be carrying out this kind of reconstruction in areas of great linguistic…
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Participants
The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).
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Healthy food, healthy world
What does it mean to eat healthily and responsibly? This question is gaining a new urgency now that in many countries undernourishment is being overtaken by diseases of affluence, such as obesity, and we are also becoming more aware of the environmental impact of our eating habits. It’s time to take…
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Spatial analysis of cultural landscapes through remote and close range sensing data
What workflow of non-destructive techniques provides accurate, valuable data to improve our understanding of Caribbean archaeological landscapes? How were Amerindian settlements configured?
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Kraft Lab - Self-assembly in Biological and Soft Matter
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
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Animal Welfare Body Leiden (AWB)
The Animal Welfare Body Leiden (AWB) is an internal entity responsible for the well-being of all laboratory animals at Leiden University and the Leiden University Medical Center. It is actively involved in all aspects of research involving animals. The AWB has several legal responsibilities, including…
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Landscape, Land-Change & Well-Being in the Lesser Antilles
This research investigates the changing landscape and land use in two case studies of the coastal villages of St. Kitts and the Kalinago Territory of Dominica. By integrating human and ecological aspects of agrarian landscapes, this research analyzes how land degradation or land change impacts cultural…
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Engaging GiCheon as a Technology of Self in Contemporary Korea
This project embarks on empirical analysis of popular psycho-physical practices in contemporary Korea.
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Fundamental Research in Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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Less is more: reduced mycelial heterogeneity for improved production of enzymes and antibiotics
How can cell wall engineering approaches be used to improve streptomycetes for industry to make new antibiotics?
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Remote participation in a hybrid classroom: Interacting with students with chronic illnesses
There are about 35,000 students with chronic illnesses in the Netherlands. If they cannot receive education in the classroom, they may be able to do so from home or a hospital with hybrid education. The question in this study is: how can interaction with the teacher and fellow students be promoted?
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Using human pluripotent stem cell-derived cardiomyocytes to understand genetic variant pathogenicity in the ion channelopathy LQT2
PhD defence
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Cancer cells play hide-and-seek with immune system
When the immune system attacks cancer, the tumour modifies itself to escape the immune reaction. Researchers at LUMC published on this subject in Nature on 28 June.
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Biomolecular analyses of skeletal remains in the circum-Caribbean across the historical divide (A.D. 1000-1800)
As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.
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Zebrafish: a new engraft model to study Ewing sarcoma progression
Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?
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Animal welfare
We carry a profound responsibility for our research animals and strive to provide them with the best possible quality of life. In our studies, we make every effort to avoid and minimise discomfort for the animals. Below, you can learn more about how this is put into practice.
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Key publications
Key research articles and book chapters of the Chromatin group.
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Unravelling the genes responsible for life history traits in the giant woody cabbage (Brassica oleracea)
Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?
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Awards and Grants 2017
An overview of awards and prizes granted to our staff and students in 2017, as well as special appointments and royal distinctions.
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Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
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MARBLES - Marine Biodiversity as Sustainable Resource of Disease-Suppressive Microbes and Bioprotectants for Aquaculture and Crop Diseases
To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.
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Lend me your ears: the grammar of (un)transferable possession
The main aim of this project is to investigate the various ways in which language categorizes possession, how these are morphosyntactically encoded across and within languages, and how this distinction should be represented in a model of the language faculty.
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Evolution & Biodiversity in Plant Sciences
Plant Sciences' contribution to the Evolution & Biodiversity research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.
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South American population history revisited: multidisciplinary perspectives on the Upper Amazon
This project, South American population history revisited: multidisciplinary perspectives on the Upper Amazon (SAPPHIRE), investigates population dynamics in western South America on the basis of traces in the geographical, genetic, archaeological, ethnological, and linguistic record.
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Open Data: The Researcher Perspective
Combining results from bibliometric analyses, a global sample of researcher opinions and case-study interviews, a new report reveals that although the benefits of open research data are well known, in practice, confusion remains within the researcher community around when and how to share research…
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In shape for photoregulation
How does the photoregulation mechanism work in detail?
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Bioactive Molecules in Plant Sciences
Plant Sciences' contribution to the Bioactive Molecules research theme is to identify new plant bioactive molecules, and unravel their mechanisms of action in plant development or health, and the regulatory networks and (bio)synthetic pathways required for their production.
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igraph - To modernize the igraph interfaces to make network analysis easier
igraph development focused on improving the most-used interfaces, which are Python, R, and Mathematica. Additionally, the developers aim to make the library and the interfaces easier to maintain, focusing on long-term sustainability. This ensures that igraph continues to be a useful tool for network…
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SKY HIGH: Vertical farming a revolution in plant production
As a new vision on food production, the feasibility study on LED light to grow crops with the biological- and chemical evaluation of final products.
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In vivo tracking and biodistribution of protein aggregates
Therapeutic proteins have revolutionized the treatment of many severe diseases like multiple sclerosis, haemophilia, diabetes and many more. Unfortunately, even recombinant proteins with structures (almost) identical to those of their endogenous counterparts often induce the formation of anti drug antibodies…
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Pursuing new anti-cancer therapy as a team
Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…
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Heterogeneity in spores of food spoilage fungi
This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.
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Cattle-talk: the language of colour among East African pastoralists
What categories exist in the languages of pastoralists? Do these semantic concepts reflect universal or languagespecific tendencies? What (environment? culture?) governs the similarities (or the differences) attested crosslinguistically in cattle colour systems?
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Required documents
When you apply for admission, you’ll be asked to submit several documents.
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MtDNA Barcoding Invasive Species
What is the provenance of introduced populations?
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Molecular Pharmacology
In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…