Alireza Mashaghi from the Leiden Academic Centre for Drug Research (LACDR) will use state-of-the-art technology to investigate proteins that play a role in muscular dystrophy. His goal is to provide new insights for designing novel therapeutic strategies in the future. To accomplish this, Mashaghi receives…

On Friday 17 April Leiden Mayor Henri Lenferink will officially open the new Metabolomics Facility of Leiden University. The facility’s ultimate goal is to prevent disease and to improve health throughout the human lifespan.

This functional genomics project aims at understanding the biology of the underlying mycelium differentiation and autolysis processes in much more detail.

Exploring the landscapes of mental health and cardiometabolic research.

At the start of the COVID-19 pandemic, researchers from 15 departments at Leiden University Medical Center (LUMC) realised they could do more for patients if they joined forces. This is how the BEAT-COVID group has been able to rapidly gain knowledge about COVID-19, the role of the immune system and…

When children wean off from heavy medication, they often experience withdrawal symptoms. The severity of these symptoms is often difficult to predict. Pharmacologist Bas Goulooze developed a computer model to determine the best weaning strategy for each child. His research has now been published in…

This project intends to provide the required knowledgebase for the design of novel mild intervention protocols to prevent fungal food spoilage.

New technology offers many new possibilities for research, such as on dementia. ‘Organ-on-a-chip’ is a new technology in which small bits of organ are grown out of stem cells on a small plastic plate. A small piece of blood vessel, heart or nerve offers many new possibilities for research, such as…

Fourteen bachelor’s and master’s students are representing Leiden University in this year’s International Genetically Engineered Machine competition (iGEM). Their plan: to create a kit that can be used to quickly identify infectious diseases in case of an outbreak.

We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.

What is the effect of pesticides, fertilizers or plastic on water quality? And how do wind and rain affect the data? These are just some of the things that Leiden environmental scientists study in the 32 ditches of the Living Lab.

On Monday 28 November 2016, Ton Liefaard spoke at the International Conference on Crime Prevention and Resocialization of Children in Contact with the Criminal Justice System in Chile. In his lecture he discussed European perspectives on crime and prevention and reintegration.

A central and much debated topic in the study of language acquisition concerns the nature of the learning mechanisms that are required. Are the computational and learning mechanisms that guide learning about language structure special and specific to language or humans?

The Sanquin blood bank gathers data on every donation. Around 720,000 donations are made every year. ‘That generates a mountain of highly valuable data,’ says Leiden PhD candidate Marieke Vinkenoog.

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

How can zebrafish research help understanding human diseases?

What is the role of auxin in the initiation and process of somatic embryogenesis?

We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

As part of the NEXUS1492 project, this project will use ancient DNA techniques to shed new light on the demographic and health history of the Caribbean and the impact of European colonization on indigenous communities in the region.

On Wednesday 25 January, the British Embassy, the Global Transformations and Governance Challenges (GTGC) programme at Leiden University and Women in International Security Netherlands (WIIS-NL) were hosting a round table with Professor Bina D’Costa to discuss the prevention of conflict related sexual…

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

On 2 and 3 October 2017, a delegation of the Child Law Department has participated in the 15th European regional conference of the International Society for the Prevention of Child Abuse and Neglect in The Hague.

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

Leiden University, the LUMC and Janssen have signed a partnership agreement stating that they will collaborate in different areas, including infectious disease prevention, clinical tests, drug production and e-health. By joining forces, the three partners will be able to provide better, more innovative…

The structure of bacterial cells provides crucial clues about their interaction with their host. What are the key structural features of a bacterial cell that determine pathogenicity? What roles do these structures play in the life cycle, and how do they change during the infection process?

The Metabolomics Facility of Leiden University is now officially in operation to prevent disease and to improve health throughout the human lifespan.

Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Heart failure is a major health care problem with high mortality.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?